Profile Response Detail

Molecular Profile KRAS G12X
Therapy Gefitinib
Indication/Tumor Type lung adenocarcinoma
Response Type predicted - resistant
Create By rliu
Update By djd

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
KRAS G12X lung adenocarcinoma predicted - resistant Gefitinib Clinical Study Actionable In a clinical study, KRAS codon 12 or 13 mutations were correlated with a lack of response to Iressa (gefitinib) in patients with lung adenocarcinoma (PMID: 15696205). 15696205
PubMed Id Reference Title Details
(15696205) KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib. Full reference...