Profile Response Detail

Molecular Profile KRAS wild-type
Therapy Cabozantinib + Panitumumab
Indication/Tumor Type colorectal cancer
Response Type sensitive
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
KRAS wild-type colorectal cancer sensitive Cabozantinib + Panitumumab Phase Ib/II Actionable In a Phase Ib trial, Cometriq (cabozantinib) and Vectibix (panitumumab) combination treatment resulted in a median progression free survival of 3.7 months, median overall survival of 7.5 months, and partial response in 14% (2/14) of KRAS wild-type colorectal patients (J Clin Oncol 34, 2016 (suppl; abstr 3548)). detail...
PubMed Id Reference Title Details
Phase Ib study of cabozantinib plus panitumumab in KRAS wild-type (WT) metastatic colorectal cancer (mCRC). Full reference...