Profile Response Detail


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Molecular Profile BRAF V600E MAP2K1 V60E
Therapy Dabrafenib
Indication/Tumor Type melanoma
Response Type resistant


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF V600E MAP2K1 V60E melanoma resistant Dabrafenib Preclinical Actionable In a preclinical study, melanoma cells harboring BRAF V600E and expressing MAP2K1 V60E demonstrated resistance to treatment with Tafinlar (dabrafenib) in culture, resulting in sustained Map2k1/2 and Erk1/2 phosphorylation (PMID: 24265153). 24265153
PubMed Id Reference Title Details
(24265153) The genetic landscape of clinical resistance to RAF inhibition in metastatic melanoma. Full reference...