Profile Response Detail

Molecular Profile NOTCH1 positive
Therapy LY3039478
Indication/Tumor Type colon cancer
Response Type sensitive
Create By tyin
Update By tyin


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
NOTCH1 positive colon cancer sensitive LY3039478 Preclinical Actionable In a preclinical study, LY3039478 inhibited Notch1 cleavage and downstream gene expression, demonstrated anti-tumor activity in xenograft models of colon cancer (AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1131). detail...
PubMed Id Reference Title Details
Abstract 1131: Novel inhibitor of Notch signaling for the treatment of cancer. Full reference...