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Molecular Profile | ERBB4 E563K |
Therapy | Lapatinib |
Indication/Tumor Type | melanoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
ERBB4 E563K | melanoma | sensitive | Lapatinib | Preclinical - Cell culture | Actionable | In a preclinical study, Tykerb (lapatinib) inhibited survival and induced apoptosis in melanoma cells harboring ERBB4 E563K in culture (PMID: 19718025). | 19718025 |
PubMed Id | Reference Title | Details |
---|---|---|
(19718025) | Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4. | Full reference... |