Profile Response Detail


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Molecular Profile RET C634W
Therapy AZD1480
Indication/Tumor Type thyroid cancer
Response Type sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RET C634W thyroid cancer sensitive AZD1480 Preclinical - Cell culture Actionable In a preclinical study, AZD1480 reduced phosphorylation of RET and downstream effectors, and inhibited growth and increased apoptosis of a thyroid cancer cell line harboring RET C634W in culture (PMID: 23056499). 23056499
PubMed Id Reference Title Details
(23056499) AZD1480 blocks growth and tumorigenesis of RET- activated thyroid cancer cell lines. Full reference...