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Molecular Profile ARID1A mutant
Therapy Bevacizumab + Everolimus
Indication/Tumor Type renal cell carcinoma
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ARID1A mutant renal cell carcinoma predicted - sensitive Bevacizumab + Everolimus Case Reports/Case Series Actionable In a Phase II trial, 100% (7/7) of patients with papillary renal cell carcinoma (n=3) or unclassified renal cell carcinoma with papillary features (n=4) harboring ARID1A mutations achieved the primary endpoint of 6-month progression-free survival when treated with the combination of Afinitor (everolimus) and Avastin (bevacizumab) (PMID: 32975815; NCT01399918). 32975815
PubMed Id Reference Title Details
(32975815) Everolimus plus bevacizumab is an effective first-line treatment for patients with advanced papillary variant renal cell carcinoma: Final results from a phase II trial. Full reference...