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Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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KIT L576P | melanoma | unknown | Imatinib | Case Reports/Case Series | Actionable | In a clinical case study, Gleevec (imatinib) treatment resulted in initial tumor reduction, but was followed by disease progression at all tumor sites in a patient with metastasized labial melanoma harboring KIT L576P (PMID: 20372153). | 20372153 |
PubMed Id | Reference Title | Details |
---|---|---|
(20372153) | Clinical responses observed with imatinib or sorafenib in melanoma patients expressing mutations in KIT. | Full reference... |