Molecular Profile | Unknown unknown |
Therapy | OSI-027 |
Indication/Tumor Type | colorectal cancer |
Response Type | not applicable |
Create By | tyin |
Update By | tyin |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References | Unknown unknown | colorectal cancer | not applicable | OSI-027 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, OSI-027 inhibited mTORC1 and mTORC2 signaling and growth in colorectal cancer cell line xenograft models (PMID: 21673091). | 21673091 |
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PubMed Id | Reference Title | Details |
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(21673091) | Preclinical characterization of OSI-027, a potent and selective inhibitor of mTORC1 and mTORC2: distinct from rapamycin. | Full reference... |