Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : firstname.lastname@example.org
|Profile Treatment Approach Name||CDK4/6 Inhibitor|
|Profile Name||CDKN2A L16fs|
|Drug Class||CDK4/6 Inhibitor 13|
|PubMed Id||Reference Title||Details|
|(24495407)||Loss of CDKN2A expression is a frequent event in primary invasive melanoma and correlates with sensitivity to the CDK4/6 inhibitor PD0332991 in melanoma cell lines.||Full reference...|
|(23898052)||PD-0332991, a potent and selective inhibitor of cyclin-dependent kinase 4/6, demonstrates inhibition of proliferation in renal cell carcinoma at nanomolar concentrations and molecular markers predict for sensitivity.||Full reference...|