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Ref Type
PMID
Authors J.C. Sachdev, A. Patnaik, J. Waypa, J. Pelusi, M. Beeram, E. Im, D. Jenkins, K. McEachern, S. Lu, W. Guo, R. Tran, V. Reichert, D. Bobilev, V. Kansra, G.J. Weiss
Title Safety, pharmacodynamic, and pharmacokinetic profile of TSR-042, an anti–PD–1 monoclonal antibody, in patients (pts) with advanced solid tumors
Journal Annals of Oncology
Vol
Issue
Date
URL http://oncologypro.esmo.org/Meeting-Resources/ESMO-2017-Congress/Safety-pharmacodynamic-and-pharmacokinetic-profile-of-TSR-042-an-anti-PD-1-monoclonal-antibody-in-patients-pts-with-advanced-solid-tumo
Abstract Text Annals of Oncology (2017) 28 (suppl_5): v403-v427. Abstract # 1185P

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown Advanced Solid Tumor not applicable Dostarlimab Phase I Actionable In a Phase I trial, Dostarlimab (TSR-042) demonstrated safety and preliminary efficacy, resulted in partial response in 9.5% (2/21) and stable disease in 23.8% (5.21) of patients with advanced solid tumors (Annals of Oncology (2017) 28 (suppl_5): v403-v427. Abstract # 1185P; NCT02715284). detail...