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Ref Type
PMID
Authors J. Powderly M.R. Patel J.J. Lee J. Brody F. Meric-Bernstam E. Hamilton S. Ponce Aix J. Garcia-Corbacho Y-J. Bang M-J. Ahn S.Y. Rha K-P. Kim M. Gil Martin H. Wang A. Lazorchak T. Wyant A. Ma S. Agarwal D. Tuck A. Daud
Title CA-170, a first in class oral small molecule dual inhibitor of immune checkpoints PD-L1 and VISTA, demonstrates tumor growth inhibition in pre-clinical models and promotes T cell activation in Phase 1 study
Journal Vol Issue Date Pages Journal Short Title
Ann Oncol.
URL https://academic.oup.com/annonc/article/28/suppl_5/mdx376.007/4109221
Abstract Text Ann Oncol. 2017 Sep 18; 28 (Suppl_5): Abstract 1141PD

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
CA-170 CA-170 0 1
Drug Name Trade Name Synonyms Drug Classes Drug Description
CA-170 AUPM 170 Immune Checkpoint Inhibitor 147 PD-L1/PD-1 antibody 117 CA-170 is a small molecule inhibitor of PD-L1 (CD274) and VISTA (VSIR), which may stimulate T-cell mediated immune response against tumor cells (Ann Oncol. 2017 Sep 18; 28 (Suppl_5): Abstract 1141PD, PMID: 32554470).
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References