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Ref Type
Authors IA Mayer, CL Arteaga, R Nanda, KD Miller, K Jhaveri, AM Brufsky, H Rugo, DA Yardley, LT Vahdat, S Sadeghi, MW Audeh, L Rolfe, J Litten, A Knox, M Raponi, C Tankersley, J Isaacson, K Wride, DE Morganstern, C Vogel, RM Connolly, WJ Gradishar, R Patel etl al
Title A phase 2 open-label study of lucitanib in patients (pts) with FGF aberrant metastatic breast cancer (MBC)
Journal Cancer Res
Abstract Text Cancer Res 2017;77(4 Suppl):Abstract nr P6-11-03


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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown breast cancer not applicable Lucitanib Phase II Actionable In a Phase II trial, Lucitanib (E-3810) demonstrated acceptable toxicity and activity, resulted in a median progression-free survival of 3.5 and 2.6 months for 10mg and 15mg treatment groups respectively, with no differences in response correlated with FGFR1 and 11q amplification status in metastatic breast cancer patients (Cancer Res 2017;77(4 Suppl):Abstract nr P6-11-03). detail...