Reference Detail

Ref Type
Authors TF. Cloughesy, J Landolfi, M Vogelbaum, D Ostertag, B Elder, B Carter, CC. Chen, S Kalkanis, S Kesari, A Lai, I Lee, L Liau, T Mikkelsen, L Nghiemphu, D Piccioni, W Accomando, O Diago, D Hogan, DJ. Jolly, K Wood, H Gruber, A Das and T Walbert
Title Durable responses observed in recurrent high-grade glioma (rHGG) with Toca 511 and Toca FC treatment
Journal Mol Cancer Ther
Abstract Text Mol Cancer Ther 2018;17(1 Suppl):Abstract nr A085


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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown malignant glioma not applicable Toca 511 + Toca FC Phase Ib/II Actionable In a Phase I trial, Toca 511 and Toca FC combination treatment resulted in complete response in 3 and partial response in 2 patients with recurrent high-grade glioma, with a median duration of response of 25.2 months (Mol Cancer Ther 2018;17(1 Suppl):Abstract nr A085; NCT01470794). detail...