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Ref Type
PMID
Authors Richard B. Lock, Kathryn Evans, Raymond Yung, Tara Pritchard, Beverly A. Teicher, JianXin Duan, Yuelong Guo, Stephen W. Erickson and Malcolm A. Smith
Title The AKR1C3-Activated Prodrug OBI-3424 Exerts Profound In Vivo Efficacy Against Preclinical Models of T-Cell Acute Lymphoblastic Leukemia (T-ALL); a Pediatric Preclinical Testing Consortium Study
URL http://mct.aacrjournals.org/content/17/1_Supplement/LB-B16
Abstract Text Mol Cancer Ther 2018;17(1 Suppl):Abstract nr LB-B16

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
OBI-3424 OBI-3424 0 2
Drug Name Trade Name Synonyms Drug Classes Drug Description
OBI-3424 OBI3424|OBI 3424|TH3424|TH 3424|TH-3424 OBI-3424 (TH 3424) is an AKR1C3-activated prodrug that is converted to a DNA alkylating agent, resulting in tumor cell death (Mol Cancer Ther 2018;17(1 Suppl):Abstract nr LB-B16, PMID: 31015346).
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References