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Ref Type
PMID
Authors GL. Uy, J Godwin, MP Rettig, N Vey, M Foster, ML. Arellano, DA. Rizzieri, MS. Topp, G Huls, B Lowenberg, G Martinelli, S Paolini, F Ciceri, MG Carrabba, C Ballesteros-Merino, CB Bifulco, H Lelièvre, R La Motte-Mohs, D Li, J Sun, K Jacobs, K Spohn et. al.
Title Preliminary Results of a Phase 1 Study of Flotetuzumab, a CD123 x CD3 Bispecific Dart Protein, in Patients with Relapsed/Refractory Acute Myeloid Leukemia and Myelodysplastic Syndrome
Journal Blood
Vol
Issue
Date
URL http://www.bloodjournal.org/content/130/Suppl_1/637?sso-checked=true
Abstract Text Blood 2017 130(Suppl 1):637

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Flotetuzumab Flotetuzumab 1 2
Drug Name Trade Name Synonyms Drug Classes Drug Description
Flotetuzumab MGD006|S80880 Flotetuzumab (MGD006) is a humanized bispecific antibody that targets both CD123 and CD23, which may lead to anti-leukemic activity (Blood 2017 130(Suppl 1):637, PMID: 32493790).
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown acute myeloid leukemia not applicable Flotetuzumab Phase I Actionable In a Phase I trial, Flotetuzumab (MGD006) demonstrated safety and preliminary efficacy in patients with relapsed/refractory acute myeloid leukemia and myelodysplastic syndrome, resulted in anti-leukemic activity in 57% (8/14) of patients and an overall response rate of 43% (6/14, 3 complete response, 1 CRi, 1 MLF, 1 partial response) (Blood 2017 130(Suppl 1):637). detail...