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Ref Type
Authors Ravit Geva, Mark Voskoboynik, Amy M Beebe, Jennifer Gwo, Konstantin Dobrenkov, Elliot Chartash, Georgina V. Long
Title First-in-human phase 1 study of MK-1248, an anti-human glucocorticoid-induced tumor necrosis factor receptor (GITR) monoclonal antibody, as monotherapy or in combination with pembrolizumab in patients with advanced solid tumors.
Journal J Clin Oncol
Abstract Text J Clin Oncol 36, 2018 (suppl; abstr 3029)


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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
MK-1248 MK-1248 1 0
Drug Name Trade Name Synonyms Drug Classes Drug Description
MK-1248 MK-1248 is a monoclonal antibody binds to and activates glucocorticoid-induced TNF receptor (GITR), resulting in activation of anti-tumor immunity (J Clin Oncol 36, 2018 (suppl; abstr 3029), PMID: 32809217).
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References