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Ref Type
PMID
Authors Yan Xu, Lin Zhang, Lifang Zhu, Yingchun Wang, Mei Wang, Zhenfan Yang
Title DZD9008, an oral, wild type selective EGFR inhibitor for the treatment of non-small-cell lung cancer with Exon20 insertion and other activating mutations
Journal Vol Issue Date Pages Journal Short Title
AACR Annual Meeting 2019 Online Proceedings
URL https://www.abstractsonline.com/pp8/#!/6812/presentation/7519
Abstract Text AACR Annual Meeting 2019, Abstract 3081

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Sunvozertinib Sunvozertinib 0 1
Drug Name Trade Name Synonyms Drug Classes Drug Description
Sunvozertinib DZD9008|DZD-9008|DZD 9008 EGFR Inhibitor (Pan) 61 HER2 Inhibitor 41 Sunvozertinib (DZD9008) is an irreversible EGFR inhibitor that preferentially inhibits mutant EGFR and ERBB2 (HER2), which may lead to growth inhibition of tumor cells with EGFR activation (AACR Annual Meeting 2019, Abstract 3081, PMID: 35404393).
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References