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Ref Type
PMID
Authors Eskouhie Tchaparian
Title The antitumor activity of hyaluronic acid nimuselide-NH2 bioconjugate (CA102N) in human colorectal cancer (CRC)
Journal Cancer Res
Vol 75
Issue 15 Suppl
Date
URL https://cancerres.aacrjournals.org/content/75/15_Supplement/4471
Abstract Text Cancer Res 2015;75(15 Suppl):Abstract nr 4471

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
CA102N CA 102N|CA-102N|Nim-HA Conjugate|HA-Nimesulide CA102N is composed of sodium hyaluronate (NaHA) in conjugation with the COX-2 inhibitor nimesulide, which may target the HA receptor CD44-expressing tumor cells for growth inhibition (Cancer Res 2015;75(15 Suppl):Abstract nr 4471, PMID: 28392690).
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown colorectal cancer not applicable CA102N Preclinical - Cell line xenograft Actionable In a preclinical study, CA102N inhibited growth of colorectal cancer cell lines in culture, and resulted in rapid tumor shrinkage in cell line xenograft models (Cancer Res 2015;75(15 Suppl):Abstract nr 4471). detail...