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Authors | Eskouhie Tchaparian | ||||||||||||
Title | The antitumor activity of hyaluronic acid nimuselide-NH2 bioconjugate (CA102N) in human colorectal cancer (CRC) | ||||||||||||
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URL | https://cancerres.aacrjournals.org/content/75/15_Supplement/4471 | ||||||||||||
Abstract Text | Cancer Res 2015;75(15 Suppl):Abstract nr 4471 |
Molecular Profile | Treatment Approach |
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Gene Name | Source | Synonyms | Protein Domains | Gene Description | Gene Role |
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Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
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CA102N | CA 102N|CA-102N|Nim-HA Conjugate|HA-Nimesulide | CA102N is composed of sodium hyaluronate (NaHA) in conjugation with the COX-2 inhibitor nimesulide, which may target the HA receptor CD44-expressing tumor cells for growth inhibition (Cancer Res 2015;75(15 Suppl):Abstract nr 4471, PMID: 28392690). |
Gene | Variant | Impact | Protein Effect | Variant Description | Associated with drug Resistance |
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Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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