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Ref Type Journal Article
PMID (24467885)
Authors Li M, Rao C, Pei D, Wang L, Li Y, Gao K, Wang M, Wang J
Title Novaferon, a novel recombinant protein produced by DNA-shuffling of IFN-α, shows antitumor effect in vitro and in vivo.
Journal Vol Issue Date Pages Journal Short Title
Cancer cell international 14 1 2014 Jan 27 8 Cancer Cell Int
URL
Abstract Text A recombinant antitumor/antiviral protein (Novaferon, Nova) is a new type of interferon, which is produced by artificial design technology combining DNA-shuffling and High Throughput Screening (HTS).The in vitro biological activities, such as anti-tumor activity and antiviral activity of Nova and recombinant human interferon alpha-2b (rhIFN-α2b) was performed; in vivo anti-tumor activity in nude mice was also tested. Flow cytometry, histo-pathological analysis including HE staining and immunohistochemistry, and surface plasmon resonance assay were performed to investigate the underlying mechanisms analysis.Nova exhibited stronger anti-cancer effects compared to rhIFN-α2b in vitro and in vivo. The antitumor mechanisms of Nova may be related to S phase arrest, pro-apoptosis, and inhibition of tumor angiogenesis. Moreover, Nova exhibited a higher binding affinity for IFN receptor 2 (IFNR2) than rhIFN-α2b, which is one of the possible reasons accounting for its stronger actions against tumor cells compared with rhIFN-α2b.Nova has strong antitumor activity and could be a potentially effective therapeutic drug for cancer.

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Novaferon Novaferon 0 0
Drug Name Trade Name Synonyms Drug Classes Drug Description
Novaferon recombinant IFN Alfa-2b-like protein Novaferon is a recombinant human interferon alpha-like protein that binds to IFN receptor 2, potentially resulting increased apoptosis and reduced proliferation of tumor cells, and decreased tumor growth (PMID: 24467885).
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References