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Ref Type Journal Article
PMID (20085938)
Authors Courtney KD, Corcoran RB, Engelman JA
Title The PI3K pathway as drug target in human cancer.
Journal Journal of clinical oncology : official journal of the American Society of
Vol 28
Issue 6
Date 2010 Feb 20
URL
Abstract Text The phosphatidylinositol 3-kinase (PI3K) signaling axis impacts on cancer cell growth, survival, motility, and metabolism. This pathway is activated by several different mechanisms in cancers, including somatic mutation and amplification of genes encoding key components. In addition, PI3K signaling may serve integral functions for noncancerous cells in the tumor microenvironment. Consequently, therapeutics targeting the PI3K pathway are being developed at a rapid pace, and preclinical and early clinical studies are beginning to suggest specific strategies to effectively use them. However, the central role of PI3K signaling in a large array of diverse biologic processes raises concerns about its use in therapeutics and increases the need to develop sophisticated strategies for its use. In this review, we will discuss how PI3K signaling affects the growth and survival of tumor cells. From this vantage, we will consider how inhibitors of the PI3K signaling cascade, either alone or in combination with other therapeutics, can most effectively be used for the treatment of cancer.

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Molecular Profile Treatment Approach
PTEN Y46H Akt2 Inhibitor
PTEN T382S Akt1 Inhibitor
PTEN M264T Akt1 Inhibitor
PTEN D326H Akt2 Inhibitor
PTEN K163fs Akt Inhibitor (Pan)
PTEN F241S Akt2 Inhibitor
PTEN H61D Akt2 Inhibitor
PTEN F337fs Akt1 Inhibitor
PTEN Y176del Akt2 Inhibitor
PTEN Y68C Akt Inhibitor (Pan)
PTEN T319del Akt1 Inhibitor
PTEN R173H Akt2 Inhibitor
PTEN R15S Akt2 Inhibitor
PTEN C136R Akt1 Inhibitor
PTEN D24V Akt Inhibitor (Pan)
PTEN D109* Akt Inhibitor (Pan)
PTEN G251D Akt Inhibitor (Pan)
PTEN E242fs Akt1 Inhibitor
PTEN N323Kfs*2 Akt1 Inhibitor
PTEN P95L Akt1 Inhibitor
PTEN N94I Akt Inhibitor (Pan)
PTEN T167A Akt2 Inhibitor
PTEN F241fs Akt2 Inhibitor
PTEN M198K Akt1 Inhibitor
PTEN I8Dfs*3 Akt2 Inhibitor
PTEN D22E Akt Inhibitor (Pan)
PTEN D107G Akt1 Inhibitor
PTEN G129R Akt Inhibitor (Pan)
PTEN K254fs Akt1 Inhibitor
PTEN P96Q Akt1 Inhibitor
PTEN V53E Akt1 Inhibitor
PTEN I122S Akt1 Inhibitor
PTEN Q17* Akt2 Inhibitor
PTEN Y336* Akt2 Inhibitor
PTEN M134I Akt1 Inhibitor
PTEN Q171R Akt Inhibitor (Pan)
PTEN I101F Akt1 Inhibitor
PTEN R130fs Akt2 Inhibitor
PTEN C83* Akt2 Inhibitor
PTEN K260fs Akt Inhibitor (Pan)
PTEN R173fs Akt1 Inhibitor
PTEN G293* Akt Inhibitor (Pan)
PTEN K102fs Akt Inhibitor (Pan)
PTEN G127* Akt2 Inhibitor
PTEN V54del Akt2 Inhibitor
PTEN E284fs Akt2 Inhibitor
PTEN H118P Akt2 Inhibitor
PTEN K267fs Akt Inhibitor (Pan)
PTEN W274* Akt Inhibitor (Pan)
PTEN I253* Akt1 Inhibitor
PTEN T167N Akt Inhibitor (Pan)
PTEN K128T Akt2 Inhibitor
PTEN K254* Akt1 Inhibitor
PTEN K260* Akt2 Inhibitor
PTEN K125E Akt Inhibitor (Pan)
PTEN E299* Akt Inhibitor (Pan)
PTEN I101S Akt Inhibitor (Pan)
PTEN Y225* Akt1 Inhibitor
PTEN D92V Akt1 Inhibitor
PTEN S302Afs*5 Akt Inhibitor (Pan)
PTEN E106* Akt2 Inhibitor
PTEN L112R Akt2 Inhibitor
PTEN Y68fs Akt2 Inhibitor
PTEN T160del Akt1 Inhibitor
PTEN G129E Akt Inhibitor (Pan)
PTEN H272P Akt1 Inhibitor
PTEN M199del Akt Inhibitor (Pan)
PTEN I101N Akt2 Inhibitor
PTEN D24G Akt2 Inhibitor
PTEN E291Gfs*7 Akt2 Inhibitor
PTEN D326N Akt2 Inhibitor
PTEN G156W Akt Inhibitor (Pan)
PTEN N329fs Akt Inhibitor (Pan)
PTEN G44D Akt Inhibitor (Pan)
PTEN D268Gfs*30 Akt Inhibitor (Pan)
PTEN E99* Akt2 Inhibitor
PTEN H93D Akt1 Inhibitor
PTEN V217D Akt1 Inhibitor
PTEN W111G Akt Inhibitor (Pan)
PTEN V119del Akt Inhibitor (Pan)
PTEN D252G Akt2 Inhibitor
PTEN Q261* Akt Inhibitor (Pan)
PTEN R130K Akt2 Inhibitor
PTEN G127R Akt2 Inhibitor
PTEN L23F Akt2 Inhibitor
PTEN M264T Akt Inhibitor (Pan)
PTEN T277del Akt1 Inhibitor
PTEN Y88* Akt Inhibitor (Pan)
PTEN V290* Akt Inhibitor (Pan)
PTEN D24H Akt2 Inhibitor
PTEN I101S Akt1 Inhibitor
PTEN D326* Akt Inhibitor (Pan)
PTEN K128_R130del Akt Inhibitor (Pan)
PTEN Y27C Akt Inhibitor (Pan)
PTEN G143fs Akt2 Inhibitor
PTEN D268Gfs*30 Akt1 Inhibitor
PTEN G129D Akt2 Inhibitor
PTEN K102fs Akt1 Inhibitor
PTEN L42P Akt2 Inhibitor
PTEN E43* Akt Inhibitor (Pan)
PTEN Y174D Akt2 Inhibitor
PTEN P246fs Akt Inhibitor (Pan)
PTEN K125M Akt Inhibitor (Pan)
PTEN W111fs Akt Inhibitor (Pan)
PTEN T321fs Akt Inhibitor (Pan)
PTEN G156V Akt Inhibitor (Pan)
PTEN L318fs Akt1 Inhibitor
PTEN T167P Akt2 Inhibitor
PTEN K163* Akt Inhibitor (Pan)
PTEN K6del Akt1 Inhibitor
PTEN R173P Akt2 Inhibitor
PTEN R130A Akt1 Inhibitor
PTEN D326H Akt Inhibitor (Pan)
PTEN R41* Akt2 Inhibitor
PTEN Q214* Akt Inhibitor (Pan)
PTEN L325R Akt1 Inhibitor
PTEN E73K Akt1 Inhibitor
PTEN Y178del Akt1 Inhibitor
PTEN C211* Akt2 Inhibitor
PTEN D92H Akt2 Inhibitor
PTEN G36E Akt2 Inhibitor
PTEN T131N Akt2 Inhibitor
PTEN R159I Akt Inhibitor (Pan)
PTEN M134R Akt2 Inhibitor
PTEN V166Sfs*14 Akt2 Inhibitor
PTEN P96del Akt2 Inhibitor
PTEN L325F Akt1 Inhibitor
PTEN L108R Akt2 Inhibitor
PTEN M134L Akt Inhibitor (Pan)
PTEN T131fs Akt Inhibitor (Pan)
PTEN Y188* Akt Inhibitor (Pan)
PTEN R130K Akt1 Inhibitor
PTEN V275* Akt1 Inhibitor
PTEN W111S Akt Inhibitor (Pan)
PTEN R130fs Akt Inhibitor (Pan)
PTEN R14fs Akt Inhibitor (Pan)
PTEN W274fs Akt1 Inhibitor
PTEN G165V Akt Inhibitor (Pan)
PTEN D107Y Akt2 Inhibitor
PTEN L57* Akt Inhibitor (Pan)
PTEN T277del Akt2 Inhibitor
PTEN L320S Akt2 Inhibitor
PTEN D324del Akt Inhibitor (Pan)
PTEN P248fs Akt1 Inhibitor
PTEN R130Q Akt1 Inhibitor
PTEN R173fs Akt Inhibitor (Pan)
PTEN L108H Akt2 Inhibitor
PTEN I101F Akt2 Inhibitor
PTEN L112R Akt Inhibitor (Pan)
PTEN E43* Akt1 Inhibitor
PTEN K128_R130del Akt2 Inhibitor
PTEN C124S Akt2 Inhibitor
PTEN P246fs Akt2 Inhibitor
PTEN T131A Akt1 Inhibitor
PTEN L152R Akt1 Inhibitor
PTEN M134T Akt2 Inhibitor
PTEN E256* Akt Inhibitor (Pan)
PTEN P96R Akt Inhibitor (Pan)
PTEN W274fs Akt2 Inhibitor
PTEN loss Akt2 Inhibitor
PTEN G127N Akt1 Inhibitor
PTEN L320S Akt1 Inhibitor
PTEN Y188* Akt2 Inhibitor
PTEN D24N Akt2 Inhibitor
PTEN T277N Akt2 Inhibitor
PTEN K125* Akt Inhibitor (Pan)
PTEN N276A Akt1 Inhibitor
PTEN G129R Akt1 Inhibitor
PTEN T131L Akt1 Inhibitor
PTEN A121E Akt1 Inhibitor
PTEN R41* Akt1 Inhibitor
PTEN D252Y Akt1 Inhibitor
PTEN P96R Akt2 Inhibitor
PTEN C71W Akt1 Inhibitor
PTEN K221* Akt Inhibitor (Pan)
PTEN I28N Akt1 Inhibitor
PTEN A126P Akt Inhibitor (Pan)
PTEN R15K Akt Inhibitor (Pan)
PTEN P96del Akt1 Inhibitor
PTEN C105Y Akt1 Inhibitor
PTEN E291Gfs*7 Akt1 Inhibitor
PTEN F347L Akt Inhibitor (Pan)
PTEN T160del Akt Inhibitor (Pan)
PTEN T319* Akt1 Inhibitor
PTEN L247_P248del Akt Inhibitor (Pan)
PTEN G156V Akt1 Inhibitor
PTEN A151P Akt1 Inhibitor
PTEN R142W Akt Inhibitor (Pan)
PTEN G36E Akt Inhibitor (Pan)
PTEN G129V Akt2 Inhibitor
PTEN C124G Akt1 Inhibitor
PTEN E285* Akt1 Inhibitor
PTEN T131fs Akt2 Inhibitor
PTEN L182P Akt Inhibitor (Pan)
PTEN F241S Akt1 Inhibitor
PTEN Y68fs Akt Inhibitor (Pan)
PTEN N117S Akt2 Inhibitor
PTEN W111G Akt1 Inhibitor
PTEN N94I Akt1 Inhibitor
PTEN M35R Akt2 Inhibitor
PTEN H123Y Akt Inhibitor (Pan)
PTEN V133I Akt1 Inhibitor
PTEN V249E Akt Inhibitor (Pan)
PTEN V217G Akt Inhibitor (Pan)
PTEN R130A Akt2 Inhibitor
PTEN T277N Akt Inhibitor (Pan)
PTEN E284* Akt Inhibitor (Pan)
PTEN Q171* Akt Inhibitor (Pan)
PTEN Q149* Akt1 Inhibitor
PTEN Y16fs Akt Inhibitor (Pan)
PTEN Y174* Akt1 Inhibitor
PTEN C136F Akt Inhibitor (Pan)
PTEN T167P Akt1 Inhibitor
PTEN D92A Akt1 Inhibitor
PTEN P38R Akt1 Inhibitor
PTEN W274* Akt2 Inhibitor
PTEN N276S Akt2 Inhibitor
PTEN K163fs Akt1 Inhibitor
PTEN negative Akt Inhibitor (Pan)
PTEN A126S Akt Inhibitor (Pan)
PTEN K197* Akt Inhibitor (Pan)
PTEN D107V Akt1 Inhibitor
PTEN T131A Akt Inhibitor (Pan)
PTEN L112P Akt2 Inhibitor
PTEN R15S Akt1 Inhibitor
PTEN Y65* Akt Inhibitor (Pan)
PTEN Y138L Akt1 Inhibitor
PTEN R130fs Akt1 Inhibitor
PTEN H123Y Akt2 Inhibitor
PTEN G251V Akt2 Inhibitor
PTEN L23S Akt1 Inhibitor
PTEN L181P Akt1 Inhibitor
PTEN C124R Akt1 Inhibitor
PTEN S170I Akt Inhibitor (Pan)
PTEN Y68fs Akt1 Inhibitor
PTEN Y65D Akt2 Inhibitor
PTEN Y176* Akt1 Inhibitor
PTEN Y155N Akt Inhibitor (Pan)
PTEN K6* Akt2 Inhibitor
PTEN N329fs Akt1 Inhibitor
PTEN V54fs Akt1 Inhibitor
PTEN N276K Akt Inhibitor (Pan)
PTEN G132del Akt Inhibitor (Pan)
PTEN E114* Akt Inhibitor (Pan)
PTEN R335L Akt Inhibitor (Pan)
PTEN Y68D Akt Inhibitor (Pan)
PTEN N184Efs*16 Akt1 Inhibitor
PTEN Y188del Akt1 Inhibitor
PTEN P38F Akt1 Inhibitor
PTEN Y27fs Akt2 Inhibitor
PTEN Y27C Akt1 Inhibitor
PTEN E91* Akt2 Inhibitor
PTEN R130* Akt2 Inhibitor
PTEN M134T Akt1 Inhibitor
PTEN I33N Akt2 Inhibitor
PTEN L146* Akt Inhibitor (Pan)
PTEN D52del Akt1 Inhibitor
PTEN N329fs Akt2 Inhibitor
PTEN C105F Akt Inhibitor (Pan)
PTEN R233* Akt Inhibitor (Pan)
PTEN Q171R Akt1 Inhibitor
PTEN A126D Akt1 Inhibitor
PTEN G282* Akt2 Inhibitor
PTEN K128E Akt1 Inhibitor
PTEN L345Q Akt1 Inhibitor
PTEN S170N Akt1 Inhibitor
PTEN D24H Akt1 Inhibitor
PTEN V343E Akt1 Inhibitor
PTEN T131N Akt Inhibitor (Pan)
PTEN G165V Akt1 Inhibitor
PTEN V275* Akt2 Inhibitor
PTEN H93Q Akt Inhibitor (Pan)
PTEN L139* Akt2 Inhibitor
PTEN P38F Akt Inhibitor (Pan)
PTEN E201* Akt Inhibitor (Pan)
PTEN K128T Akt Inhibitor (Pan)
PTEN R14fs Akt2 Inhibitor
PTEN N276K Akt1 Inhibitor
PTEN L182fs Akt2 Inhibitor
PTEN L146* Akt2 Inhibitor
PTEN S385* Akt2 Inhibitor
PTEN L42R Akt Inhibitor (Pan)
PTEN C136Y Akt2 Inhibitor
PTEN P38H Akt1 Inhibitor
PTEN Y46H Akt1 Inhibitor
PTEN V133I Akt Inhibitor (Pan)
PTEN K183Ifs*15 Akt2 Inhibitor
PTEN K342* Akt1 Inhibitor
PTEN negative Akt2 Inhibitor
PTEN G165E Akt Inhibitor (Pan)
PTEN R55fs Akt1 Inhibitor
PTEN E157* Akt1 Inhibitor
PTEN R159I Akt1 Inhibitor
PTEN K13* Akt1 Inhibitor
PTEN C124S Akt Inhibitor (Pan)
PTEN G127* Akt1 Inhibitor
PTEN N117S Akt Inhibitor (Pan)
PTEN K266* Akt1 Inhibitor
PTEN G165* Akt2 Inhibitor
PTEN K6* Akt1 Inhibitor
PTEN D107G Akt2 Inhibitor
PTEN Y27D Akt Inhibitor (Pan)
PTEN P339L Akt1 Inhibitor
PTEN L247* Akt2 Inhibitor
PTEN T131A Akt2 Inhibitor
PTEN T232A Akt Inhibitor (Pan)
PTEN P38T Akt Inhibitor (Pan)
PTEN N323Kfs*2 Akt2 Inhibitor
PTEN E288fs Akt Inhibitor (Pan)
PTEN K128E Akt2 Inhibitor
PTEN A126fs Akt1 Inhibitor
PTEN P248fs Akt2 Inhibitor
PTEN M134del Akt Inhibitor (Pan)
PTEN K147* Akt2 Inhibitor
PTEN K266* Akt2 Inhibitor
PTEN L23V Akt2 Inhibitor
PTEN D24N Akt1 Inhibitor
PTEN R335* Akt1 Inhibitor
PTEN K125N Akt2 Inhibitor
PTEN negative Akt1 Inhibitor
PTEN E256* Akt2 Inhibitor
PTEN Q298fs Akt Inhibitor (Pan)
PTEN S287* Akt2 Inhibitor
PTEN G165R Akt Inhibitor (Pan)
PTEN G36* Akt1 Inhibitor
PTEN Y27N Akt1 Inhibitor
PTEN E91* Akt1 Inhibitor
PTEN E114* Akt2 Inhibitor
PTEN S10N Akt1 Inhibitor
PTEN L318fs Akt2 Inhibitor
PTEN C218* Akt2 Inhibitor
PTEN P96del Akt Inhibitor (Pan)
PTEN Q110* Akt Inhibitor (Pan)
PTEN D109* Akt2 Inhibitor
PTEN L108H Akt1 Inhibitor
PTEN K254Rfs*42 Akt2 Inhibitor
PTEN T167A Akt Inhibitor (Pan)
PTEN V317fs Akt1 Inhibitor
PTEN R15I Akt Inhibitor (Pan)
PTEN V54fs Akt Inhibitor (Pan)
PTEN G132D Akt1 Inhibitor
PTEN Y155fs Akt2 Inhibitor
PTEN E291Gfs*7 Akt Inhibitor (Pan)
PTEN I122S Akt2 Inhibitor
PTEN L57W Akt1 Inhibitor
PTEN M134I Akt Inhibitor (Pan)
PTEN L57* Akt1 Inhibitor
PTEN E150* Akt2 Inhibitor
PTEN Y155C Akt2 Inhibitor
PTEN T382S Akt Inhibitor (Pan)
PTEN R142P Akt2 Inhibitor
PTEN V217D Akt2 Inhibitor
PTEN N48K Akt Inhibitor (Pan)
PTEN G127R Akt1 Inhibitor
PTEN Q261* Akt1 Inhibitor
PTEN L57fs Akt1 Inhibitor
PTEN L108R Akt Inhibitor (Pan)
PTEN F90S Akt1 Inhibitor
PTEN K254Rfs*42 Akt1 Inhibitor
PTEN D116fs Akt Inhibitor (Pan)
PTEN E299* Akt1 Inhibitor
PTEN A151P Akt2 Inhibitor
PTEN H61R Akt Inhibitor (Pan)
PTEN Y155H Akt1 Inhibitor
PTEN S10N Akt2 Inhibitor
PTEN K342* Akt2 Inhibitor
PTEN K128E Akt Inhibitor (Pan)
PTEN P95S Akt1 Inhibitor
PTEN H141P Akt2 Inhibitor
PTEN Y65* Akt2 Inhibitor
PTEN I253* Akt Inhibitor (Pan)
PTEN D331Tfs*13 Akt Inhibitor (Pan)
PTEN N323fs Akt2 Inhibitor
PTEN G127* Akt Inhibitor (Pan)
PTEN Q110* Akt1 Inhibitor
PTEN P38H Akt2 Inhibitor
PTEN P38F Akt2 Inhibitor
PTEN E99* Akt1 Inhibitor
PTEN K263* Akt2 Inhibitor
PTEN H123R Akt1 Inhibitor
PTEN V158fs Akt1 Inhibitor
PTEN K330* Akt2 Inhibitor
PTEN L70V Akt Inhibitor (Pan)
PTEN D162del Akt2 Inhibitor
PTEN F337fs Akt2 Inhibitor
PTEN G251C Akt1 Inhibitor
PTEN R159I Akt2 Inhibitor
PTEN H118P Akt1 Inhibitor
PTEN L57W Akt Inhibitor (Pan)
PTEN I33N Akt1 Inhibitor
PTEN K163* Akt2 Inhibitor
PTEN Y46H Akt Inhibitor (Pan)
PTEN H123Q Akt1 Inhibitor
PTEN D52del Akt Inhibitor (Pan)
PTEN G36R Akt2 Inhibitor
PTEN H123D Akt1 Inhibitor
PTEN C136R Akt Inhibitor (Pan)
PTEN H93L Akt2 Inhibitor
PTEN V166G Akt1 Inhibitor
PTEN E307* Akt Inhibitor (Pan)
PTEN Y27fs Akt1 Inhibitor
PTEN R159L Akt2 Inhibitor
PTEN Y16fs Akt2 Inhibitor
PTEN V166Sfs*14 Akt1 Inhibitor
PTEN T348I Akt2 Inhibitor
PTEN E242fs Akt Inhibitor (Pan)
PTEN D107V Akt2 Inhibitor
PTEN Q87* Akt2 Inhibitor
PTEN R335* Akt Inhibitor (Pan)
PTEN L42R Akt1 Inhibitor
PTEN G129D Akt1 Inhibitor
PTEN L193P Akt2 Inhibitor
PTEN D107V Akt Inhibitor (Pan)
PTEN D24Y Akt1 Inhibitor
PTEN R130A Akt Inhibitor (Pan)
PTEN K322E Akt Inhibitor (Pan)
PTEN A34P Akt1 Inhibitor
PTEN G129V Akt Inhibitor (Pan)
PTEN Y46* Akt1 Inhibitor
PTEN T131I Akt1 Inhibitor
PTEN G156W Akt2 Inhibitor
PTEN M264R Akt Inhibitor (Pan)
PTEN T131N Akt1 Inhibitor
PTEN K13Q Akt1 Inhibitor
PTEN N48S Akt Inhibitor (Pan)
PTEN V119del Akt1 Inhibitor
PTEN A39P Akt1 Inhibitor
PTEN Q87* Akt Inhibitor (Pan)
PTEN I135K Akt1 Inhibitor
PTEN A121P Akt2 Inhibitor
PTEN A121P Akt Inhibitor (Pan)
PTEN R14fs Akt1 Inhibitor
PTEN D24V Akt1 Inhibitor
PTEN D22E Akt1 Inhibitor
PTEN Y188del Akt Inhibitor (Pan)
PTEN Y155H Akt Inhibitor (Pan)
PTEN C124W Akt1 Inhibitor
PTEN N340fs Akt2 Inhibitor
PTEN R55fs Akt2 Inhibitor
PTEN C71Y Akt2 Inhibitor
PTEN L193fs Akt2 Inhibitor
PTEN W111* Akt2 Inhibitor
PTEN E299* Akt2 Inhibitor
PTEN S294fs Akt2 Inhibitor
PTEN F241fs Akt Inhibitor (Pan)
PTEN loss Akt Inhibitor (Pan)
PTEN H272P Akt2 Inhibitor
PTEN G165* Akt Inhibitor (Pan)
PTEN Y65C Akt1 Inhibitor
PTEN E314* Akt2 Inhibitor
PTEN Y177D Akt2 Inhibitor
PTEN E288* Akt2 Inhibitor
PTEN F341V Akt1 Inhibitor
PTEN S170N Akt2 Inhibitor
PTEN N12T Akt1 Inhibitor
PTEN P96Q Akt Inhibitor (Pan)
PTEN V217fs Akt2 Inhibitor
PTEN R173C Akt2 Inhibitor
PTEN E242* Akt1 Inhibitor
PTEN K221* Akt2 Inhibitor
PTEN Y88* Akt2 Inhibitor
PTEN Y68N Akt Inhibitor (Pan)
PTEN Y88D Akt Inhibitor (Pan)
PTEN V166G Akt2 Inhibitor
PTEN H272P Akt Inhibitor (Pan)
PTEN T160I Akt2 Inhibitor
PTEN R173P Akt Inhibitor (Pan)
PTEN W111S Akt2 Inhibitor
PTEN K128Q Akt2 Inhibitor
PTEN M134del Akt1 Inhibitor
PTEN G251V Akt Inhibitor (Pan)
PTEN W111G Akt2 Inhibitor
PTEN I101T Akt1 Inhibitor
PTEN S294fs Akt1 Inhibitor
PTEN E284* Akt1 Inhibitor
PTEN E288* Akt Inhibitor (Pan)
PTEN I122L Akt1 Inhibitor
PTEN H123L Akt1 Inhibitor
PTEN D77* Akt1 Inhibitor
PTEN A121E Akt2 Inhibitor
PTEN R130P Akt1 Inhibitor
PTEN Y177D Akt1 Inhibitor
PTEN Q149* Akt2 Inhibitor
PTEN F257L Akt1 Inhibitor
PTEN Y65S Akt1 Inhibitor
PTEN E7* Akt2 Inhibitor
PTEN I8Dfs*3 Akt1 Inhibitor
PTEN K13E Akt Inhibitor (Pan)
PTEN K125L Akt Inhibitor (Pan)
PTEN R130Q Akt Inhibitor (Pan)
PTEN M198K Akt2 Inhibitor
PTEN D24V Akt2 Inhibitor
PTEN Y16fs Akt1 Inhibitor
PTEN R41* Akt Inhibitor (Pan)
PTEN I122F Akt1 Inhibitor
PTEN G282* Akt Inhibitor (Pan)
PTEN N12T Akt2 Inhibitor
PTEN Y174D Akt Inhibitor (Pan)
PTEN K266* Akt Inhibitor (Pan)
PTEN E242* Akt2 Inhibitor
PTEN Y76fs Akt Inhibitor (Pan)
PTEN E18* Akt Inhibitor (Pan)
PTEN K128Q Akt1 Inhibitor
PTEN D24G Akt Inhibitor (Pan)
PTEN R74Dfs*25 Akt1 Inhibitor
PTEN del Akt1 Inhibitor
PTEN Y68C Akt1 Inhibitor
PTEN L325F Akt2 Inhibitor
PTEN Y76fs Akt1 Inhibitor
PTEN L247_P248del Akt1 Inhibitor
PTEN K6fs Akt Inhibitor (Pan)
PTEN G251V Akt1 Inhibitor
PTEN L23F Akt1 Inhibitor
PTEN C136F Akt1 Inhibitor
PTEN N63fs Akt1 Inhibitor
PTEN G127E Akt1 Inhibitor
PTEN G129V Akt1 Inhibitor
PTEN R15I Akt1 Inhibitor
PTEN D116fs Akt2 Inhibitor
PTEN G132D Akt Inhibitor (Pan)
PTEN E256* Akt1 Inhibitor
PTEN H118P Akt Inhibitor (Pan)
PTEN M35K Akt Inhibitor (Pan)
PTEN L70fs Akt Inhibitor (Pan)
PTEN S385* Akt Inhibitor (Pan)
PTEN V255A Akt1 Inhibitor
PTEN T131I Akt2 Inhibitor
PTEN L265fs Akt1 Inhibitor
PTEN E242fs Akt2 Inhibitor
PTEN A126V Akt2 Inhibitor
PTEN M198K Akt Inhibitor (Pan)
PTEN N12T Akt Inhibitor (Pan)
PTEN E314* Akt1 Inhibitor
PTEN H123Y Akt1 Inhibitor
PTEN E288* Akt1 Inhibitor
PTEN Y315* Akt2 Inhibitor
PTEN C71W Akt Inhibitor (Pan)
PTEN L23S Akt Inhibitor (Pan)
PTEN Y138L Akt2 Inhibitor
PTEN T319* Akt Inhibitor (Pan)
PTEN V53E Akt Inhibitor (Pan)
PTEN I101S Akt2 Inhibitor
PTEN R234* Akt2 Inhibitor
PTEN E7* Akt1 Inhibitor
PTEN T277del Akt Inhibitor (Pan)
PTEN N276A Akt Inhibitor (Pan)
PTEN V275G Akt1 Inhibitor
PTEN K330* Akt1 Inhibitor
PTEN I33S Akt2 Inhibitor
PTEN C71W Akt2 Inhibitor
PTEN L23S Akt2 Inhibitor
PTEN V290fs Akt2 Inhibitor
PTEN T319* Akt2 Inhibitor
PTEN G165R Akt2 Inhibitor
PTEN R189* Akt2 Inhibitor
PTEN Y174N Akt Inhibitor (Pan)
PTEN S59* Akt Inhibitor (Pan)
PTEN D24del Akt2 Inhibitor
PTEN D24del Akt Inhibitor (Pan)
PTEN H141P Akt1 Inhibitor
PTEN del Akt2 Inhibitor
PTEN M199del Akt2 Inhibitor
PTEN S59P Akt Inhibitor (Pan)
PTEN Y88* Akt1 Inhibitor
PTEN K342* Akt Inhibitor (Pan)
PTEN T321* Akt Inhibitor (Pan)
PTEN H118fs Akt Inhibitor (Pan)
PTEN Y27N Akt2 Inhibitor
PTEN E307* Akt2 Inhibitor
PTEN T160del Akt2 Inhibitor
PTEN G129R Akt2 Inhibitor
PTEN S59P Akt1 Inhibitor
PTEN C105Y Akt2 Inhibitor
PTEN E157G Akt2 Inhibitor
PTEN T348I Akt1 Inhibitor
PTEN F337fs Akt Inhibitor (Pan)
PTEN Y177* Akt1 Inhibitor
PTEN K260fs Akt2 Inhibitor
PTEN F56fs Akt Inhibitor (Pan)
PTEN A126G Akt2 Inhibitor
PTEN Q110* Akt2 Inhibitor
PTEN R130S Akt Inhibitor (Pan)
PTEN D92A Akt Inhibitor (Pan)
PTEN L140* Akt Inhibitor (Pan)
PTEN L181P Akt2 Inhibitor
PTEN V249E Akt2 Inhibitor
PTEN K62R Akt2 Inhibitor
PTEN K289Nfs*8 Akt1 Inhibitor
PTEN D77* Akt2 Inhibitor
PTEN Y68D Akt2 Inhibitor
PTEN I67K Akt Inhibitor (Pan)
PTEN T321fs Akt2 Inhibitor
PTEN G165E Akt1 Inhibitor
PTEN M134L Akt2 Inhibitor
PTEN I253* Akt2 Inhibitor
PTEN I122fs Akt1 Inhibitor
PTEN H123R Akt Inhibitor (Pan)
PTEN K6I Akt Inhibitor (Pan)
PTEN L42P Akt1 Inhibitor
PTEN V290Sfs*8 Akt Inhibitor (Pan)
PTEN K6fs Akt2 Inhibitor
PTEN T321* Akt2 Inhibitor
PTEN H123R Akt2 Inhibitor
PTEN S294fs Akt Inhibitor (Pan)
PTEN V343E Akt2 Inhibitor
PTEN D24del Akt1 Inhibitor
PTEN L112P Akt Inhibitor (Pan)
PTEN D331Tfs*13 Akt1 Inhibitor
PTEN Y174D Akt1 Inhibitor
PTEN E91* Akt Inhibitor (Pan)
PTEN D162Y Akt2 Inhibitor
PTEN E201* Akt1 Inhibitor
PTEN K183Ifs*15 Akt Inhibitor (Pan)
PTEN Q149* Akt Inhibitor (Pan)
PTEN Q214* Akt1 Inhibitor
PTEN H93Q Akt1 Inhibitor
PTEN G156W Akt1 Inhibitor
PTEN F145* Akt Inhibitor (Pan)
PTEN H61R Akt1 Inhibitor
PTEN V275G Akt Inhibitor (Pan)
PTEN K13E Akt2 Inhibitor
PTEN V317fs Akt Inhibitor (Pan)
PTEN Y155C Akt1 Inhibitor
PTEN G156V Akt2 Inhibitor
PTEN K128_R130del Akt1 Inhibitor
PTEN A72fs Akt2 Inhibitor
PTEN D252G Akt Inhibitor (Pan)
PTEN C124W Akt2 Inhibitor
PTEN E43* Akt2 Inhibitor
PTEN C105F Akt1 Inhibitor
PTEN Y27D Akt1 Inhibitor
PTEN L70fs Akt2 Inhibitor
PTEN Y178* Akt Inhibitor (Pan)
PTEN C124G Akt Inhibitor (Pan)
PTEN K6E Akt2 Inhibitor
PTEN G129* Akt2 Inhibitor
PTEN F154L Akt Inhibitor (Pan)
PTEN E285* Akt2 Inhibitor
PTEN F241S Akt Inhibitor (Pan)
PTEN D331fs Akt2 Inhibitor
PTEN R15S Akt Inhibitor (Pan)
PTEN L146* Akt1 Inhibitor
PTEN I122F Akt Inhibitor (Pan)
PTEN K260* Akt Inhibitor (Pan)
PTEN P38R Akt2 Inhibitor
PTEN K125L Akt1 Inhibitor
PTEN Q171E Akt1 Inhibitor
PTEN K269* Akt1 Inhibitor
PTEN H93P Akt1 Inhibitor
PTEN K237fs Akt1 Inhibitor
PTEN E235* Akt1 Inhibitor
PTEN F56C Akt Inhibitor (Pan)
PTEN M198R Akt Inhibitor (Pan)
PTEN H123Q Akt2 Inhibitor
PTEN L108P Akt2 Inhibitor
PTEN V175E Akt2 Inhibitor
PTEN L139* Akt1 Inhibitor
PTEN C136F Akt2 Inhibitor
PTEN E235* Akt2 Inhibitor
PTEN D116fs Akt1 Inhibitor
PTEN G20E Akt1 Inhibitor
PTEN N48S Akt2 Inhibitor
PTEN L345Q Akt Inhibitor (Pan)
PTEN M35V Akt2 Inhibitor
PTEN P95L Akt Inhibitor (Pan)
PTEN V217fs Akt1 Inhibitor
PTEN K125M Akt1 Inhibitor
PTEN L70P Akt2 Inhibitor
PTEN D24Y Akt2 Inhibitor
PTEN R130S Akt2 Inhibitor
PTEN I101T Akt Inhibitor (Pan)
PTEN D252G Akt1 Inhibitor
PTEN P246fs Akt1 Inhibitor
PTEN Y76* Akt1 Inhibitor
PTEN Y46* Akt Inhibitor (Pan)
PTEN M134L Akt1 Inhibitor
PTEN T131L Akt2 Inhibitor
PTEN loss Akt1 Inhibitor
PTEN T232A Akt1 Inhibitor
PTEN F241fs Akt1 Inhibitor
PTEN Y155fs Akt Inhibitor (Pan)
PTEN H93Y Akt1 Inhibitor
PTEN W274* Akt1 Inhibitor
PTEN I135R Akt2 Inhibitor
PTEN Y176del Akt Inhibitor (Pan)
PTEN K267* Akt Inhibitor (Pan)
PTEN K267* Akt1 Inhibitor
PTEN C218* Akt Inhibitor (Pan)
PTEN N323Kfs*2 Akt Inhibitor (Pan)
PTEN K260fs Akt1 Inhibitor
PTEN V54del Akt Inhibitor (Pan)
PTEN A126fs Akt Inhibitor (Pan)
PTEN V343E Akt Inhibitor (Pan)
PTEN V166E Akt2 Inhibitor
PTEN R173C Akt1 Inhibitor
PTEN E73K Akt2 Inhibitor
PTEN I122fs Akt Inhibitor (Pan)
PTEN S170R Akt1 Inhibitor
PTEN K66fs Akt2 Inhibitor
PTEN L70V Akt2 Inhibitor
PTEN E7* Akt Inhibitor (Pan)
PTEN T131fs Akt1 Inhibitor
PTEN S170N Akt Inhibitor (Pan)
PTEN K147* Akt Inhibitor (Pan)
PTEN V166E Akt1 Inhibitor
PTEN T160I Akt1 Inhibitor
PTEN Y177D Akt Inhibitor (Pan)
PTEN D92E Akt Inhibitor (Pan)
PTEN G165V Akt2 Inhibitor
PTEN F271S Akt1 Inhibitor
PTEN C250fs Akt1 Inhibitor
PTEN K263* Akt1 Inhibitor
PTEN Y27D Akt2 Inhibitor
PTEN C83* Akt Inhibitor (Pan)
PTEN Y178* Akt1 Inhibitor
PTEN N212Kfs*10 Akt2 Inhibitor
PTEN I122F Akt2 Inhibitor
PTEN S59* Akt2 Inhibitor
PTEN Y68H Akt2 Inhibitor
PTEN P96R Akt1 Inhibitor
PTEN K289Nfs*8 Akt Inhibitor (Pan)
PTEN K125E Akt1 Inhibitor
PTEN K163fs Akt2 Inhibitor
PTEN K125* Akt2 Inhibitor
PTEN F154L Akt1 Inhibitor
PTEN D77* Akt Inhibitor (Pan)
PTEN D52del Akt2 Inhibitor
PTEN Q17Kfs*7 Akt1 Inhibitor
PTEN L112R Akt1 Inhibitor
PTEN S170I Akt2 Inhibitor
PTEN N292fs Akt2 Inhibitor
PTEN L325R Akt2 Inhibitor
PTEN A126G Akt1 Inhibitor
PTEN D107Y Akt Inhibitor (Pan)
PTEN N323fs Akt Inhibitor (Pan)
PTEN G293fs Akt1 Inhibitor
PTEN R130S Akt1 Inhibitor
PTEN Y16D Akt1 Inhibitor
PTEN L140F Akt1 Inhibitor
PTEN H93L Akt Inhibitor (Pan)
PTEN Q298* Akt1 Inhibitor
PTEN C124R Akt2 Inhibitor
PTEN E291* Akt2 Inhibitor
PTEN P38T Akt2 Inhibitor
PTEN L42P Akt Inhibitor (Pan)
PTEN E150* Akt1 Inhibitor
PTEN Y178del Akt2 Inhibitor
PTEN T277N Akt1 Inhibitor
PTEN Y65C Akt2 Inhibitor
PTEN L139* Akt Inhibitor (Pan)
PTEN C136Y Akt Inhibitor (Pan)
PTEN R173C Akt Inhibitor (Pan)
PTEN V133I Akt2 Inhibitor
PTEN L140F Akt Inhibitor (Pan)
PTEN I135K Akt2 Inhibitor
PTEN Y27S Akt2 Inhibitor
PTEN Y155N Akt2 Inhibitor
PTEN Q171E Akt2 Inhibitor
PTEN R14G Akt Inhibitor (Pan)
PTEN R159L Akt1 Inhibitor
PTEN N276A Akt2 Inhibitor
PTEN R14G Akt2 Inhibitor
PTEN R130L Akt Inhibitor (Pan)
PTEN T160I Akt Inhibitor (Pan)
PTEN G129D Akt Inhibitor (Pan)
PTEN Y68N Akt1 Inhibitor
PTEN G165E Akt2 Inhibitor
PTEN K147* Akt1 Inhibitor
PTEN K60fs Akt1 Inhibitor
PTEN T321fs Akt1 Inhibitor
PTEN M264R Akt1 Inhibitor
PTEN Y76fs Akt2 Inhibitor
PTEN W111fs Akt2 Inhibitor
PTEN K60fs Akt2 Inhibitor
PTEN Y76* Akt2 Inhibitor
PTEN D107Y Akt1 Inhibitor
PTEN K163* Akt1 Inhibitor
PTEN H123L Akt Inhibitor (Pan)
PTEN M264R Akt2 Inhibitor
PTEN K197* Akt2 Inhibitor
PTEN L57fs Akt Inhibitor (Pan)
PTEN K6E Akt1 Inhibitor
PTEN K6fs Akt1 Inhibitor
PTEN R130L Akt1 Inhibitor
PTEN Y27N Akt Inhibitor (Pan)
PTEN A126G Akt Inhibitor (Pan)
PTEN Q87* Akt1 Inhibitor
PTEN F56fs Akt2 Inhibitor
PTEN H93Y Akt Inhibitor (Pan)
PTEN L70P Akt Inhibitor (Pan)
PTEN R189* Akt Inhibitor (Pan)
PTEN T131L Akt Inhibitor (Pan)
PTEN P96Q Akt2 Inhibitor
PTEN C211W Akt1 Inhibitor
PTEN S170R Akt2 Inhibitor
PTEN N276T Akt1 Inhibitor
PTEN V217G Akt1 Inhibitor
PTEN L193P Akt1 Inhibitor
PTEN C211W Akt2 Inhibitor
PTEN M35K Akt2 Inhibitor
PTEN M35K Akt1 Inhibitor
PTEN D92E Akt2 Inhibitor
PTEN N212Kfs*10 Akt Inhibitor (Pan)
PTEN L140* Akt2 Inhibitor
PTEN Y68H Akt Inhibitor (Pan)
PTEN T319fs Akt Inhibitor (Pan)
PTEN M264T Akt2 Inhibitor
PTEN D92G Akt2 Inhibitor
PTEN F21A Akt Inhibitor (Pan)
PTEN L57* Akt2 Inhibitor
PTEN N63fs Akt Inhibitor (Pan)
PTEN K125L Akt2 Inhibitor
PTEN Y178del Akt Inhibitor (Pan)
PTEN Y46* Akt2 Inhibitor
PTEN S287* Akt Inhibitor (Pan)
PTEN H93L Akt1 Inhibitor
PTEN H93P Akt2 Inhibitor
PTEN C124G Akt2 Inhibitor
PTEN T167P Akt Inhibitor (Pan)
PTEN S10N Akt Inhibitor (Pan)
PTEN D107G Akt Inhibitor (Pan)
PTEN A126S Akt1 Inhibitor
PTEN T232A Akt2 Inhibitor
PTEN D109* Akt1 Inhibitor
PTEN M198R Akt1 Inhibitor
PTEN V54del Akt1 Inhibitor
PTEN N276T Akt2 Inhibitor
PTEN F90S Akt2 Inhibitor
PTEN E106* Akt Inhibitor (Pan)
PTEN W111fs Akt1 Inhibitor
PTEN Y16D Akt2 Inhibitor
PTEN E307* Akt1 Inhibitor
PTEN C211* Akt1 Inhibitor
PTEN G36R Akt1 Inhibitor
PTEN E235* Akt Inhibitor (Pan)
PTEN V290Sfs*8 Akt1 Inhibitor
PTEN L112P Akt1 Inhibitor
PTEN N292fs Akt Inhibitor (Pan)
PTEN G282* Akt1 Inhibitor
PTEN G127N Akt2 Inhibitor
PTEN D268Gfs*30 Akt2 Inhibitor
PTEN E73K Akt Inhibitor (Pan)
PTEN C211W Akt Inhibitor (Pan)
PTEN R142P Akt1 Inhibitor
PTEN L23V Akt1 Inhibitor
PTEN G143fs Akt1 Inhibitor
PTEN A126fs Akt2 Inhibitor
PTEN inact mut Akt Inhibitor (Pan)
PTEN V119del Akt2 Inhibitor
PTEN A34D Akt2 Inhibitor
PTEN K254Rfs*42 Akt Inhibitor (Pan)
PTEN G129* Akt1 Inhibitor
PTEN C71Y Akt1 Inhibitor
PTEN A126V Akt Inhibitor (Pan)
PTEN D326H Akt1 Inhibitor
PTEN D24N Akt Inhibitor (Pan)
PTEN R130G Akt1 Inhibitor
PTEN D326* Akt2 Inhibitor
PTEN A72fs Akt1 Inhibitor
PTEN M35V Akt Inhibitor (Pan)
PTEN Y174N Akt2 Inhibitor
PTEN M134I Akt2 Inhibitor
PTEN Q171E Akt Inhibitor (Pan)
PTEN M134del Akt2 Inhibitor
PTEN K322E Akt2 Inhibitor
PTEN F341V Akt Inhibitor (Pan)
PTEN V119fs Akt2 Inhibitor
PTEN A126P Akt1 Inhibitor
PTEN S227F Akt2 Inhibitor
PTEN N276T Akt Inhibitor (Pan)
PTEN Q171R Akt2 Inhibitor
PTEN W111* Akt1 Inhibitor
PTEN V158fs Akt Inhibitor (Pan)
PTEN Y88D Akt1 Inhibitor
PTEN L325R Akt Inhibitor (Pan)
PTEN E157* Akt Inhibitor (Pan)
PTEN L247* Akt Inhibitor (Pan)
PTEN D92E Akt1 Inhibitor
PTEN G20E Akt2 Inhibitor
PTEN P248fs Akt Inhibitor (Pan)
PTEN F21A Akt1 Inhibitor
PTEN C105Y Akt Inhibitor (Pan)
PTEN W274fs Akt Inhibitor (Pan)
PTEN C124L Akt2 Inhibitor
PTEN L193fs Akt Inhibitor (Pan)
PTEN A126D Akt Inhibitor (Pan)
PTEN I122S Akt Inhibitor (Pan)
PTEN V119fs Akt Inhibitor (Pan)
PTEN K125M Akt2 Inhibitor
PTEN H93Y Akt2 Inhibitor
PTEN Y336* Akt1 Inhibitor
PTEN Y65D Akt1 Inhibitor
PTEN D252Y Akt Inhibitor (Pan)
PTEN I101N Akt1 Inhibitor
PTEN K267fs Akt2 Inhibitor
PTEN K13Q Akt Inhibitor (Pan)
PTEN C250fs Akt2 Inhibitor
PTEN Y315* Akt1 Inhibitor
PTEN G129* Akt Inhibitor (Pan)
PTEN V175E Akt1 Inhibitor
PTEN T167N Akt1 Inhibitor
PTEN L57S Akt2 Inhibitor
PTEN P38H Akt Inhibitor (Pan)
PTEN C124fs Akt Inhibitor (Pan)
PTEN H141P Akt Inhibitor (Pan)
PTEN T382S Akt2 Inhibitor
PTEN L42R Akt2 Inhibitor
PTEN R130G Akt2 Inhibitor
PTEN K267fs Akt1 Inhibitor
PTEN V317fs Akt2 Inhibitor
PTEN V217fs Akt Inhibitor (Pan)
PTEN Q214* Akt2 Inhibitor
PTEN L320S Akt Inhibitor (Pan)
PTEN T131I Akt Inhibitor (Pan)
PTEN G293* Akt1 Inhibitor
PTEN H118fs Akt1 Inhibitor
PTEN inact mut Akt1 Inhibitor
PTEN C211* Akt Inhibitor (Pan)
PTEN S229* Akt1 Inhibitor
PTEN G127R Akt Inhibitor (Pan)
PTEN Y65D Akt Inhibitor (Pan)
PTEN K254* Akt2 Inhibitor
PTEN P95S Akt2 Inhibitor
PTEN K254fs Akt2 Inhibitor
PTEN M35R Akt1 Inhibitor
PTEN G36* Akt2 Inhibitor
PTEN C124fs Akt2 Inhibitor
PTEN D324del Akt1 Inhibitor
PTEN L152P Akt2 Inhibitor
PTEN I33S Akt Inhibitor (Pan)
PTEN T321* Akt1 Inhibitor
PTEN M35R Akt Inhibitor (Pan)
PTEN E314* Akt Inhibitor (Pan)
PTEN I33S Akt1 Inhibitor
PTEN Y176* Akt Inhibitor (Pan)
PTEN G129E Akt1 Inhibitor
PTEN L140* Akt1 Inhibitor
PTEN C124R Akt Inhibitor (Pan)
PTEN F145* Akt2 Inhibitor
PTEN H123D Akt2 Inhibitor
PTEN Y46D Akt Inhibitor (Pan)
PTEN N63fs Akt2 Inhibitor
PTEN K254fs Akt Inhibitor (Pan)
PTEN Y315* Akt Inhibitor (Pan)
PTEN Y68D Akt1 Inhibitor
PTEN Y177* Akt Inhibitor (Pan)
PTEN I33N Akt Inhibitor (Pan)
PTEN E288fs Akt2 Inhibitor
PTEN K322E Akt1 Inhibitor
PTEN S10del Akt Inhibitor (Pan)
PTEN V290* Akt2 Inhibitor
PTEN M199del Akt1 Inhibitor
PTEN L181P Akt Inhibitor (Pan)
PTEN K289Nfs*8 Akt2 Inhibitor
PTEN I28N Akt2 Inhibitor
PTEN S10del Akt1 Inhibitor
PTEN D162Y Akt Inhibitor (Pan)
PTEN G132D Akt2 Inhibitor
PTEN K269* Akt Inhibitor (Pan)
PTEN Q298fs Akt2 Inhibitor
PTEN E114* Akt1 Inhibitor
PTEN V119G Akt2 Inhibitor
PTEN I122L Akt2 Inhibitor
PTEN A39P Akt Inhibitor (Pan)
PTEN K197* Akt1 Inhibitor
PTEN D92G Akt1 Inhibitor
PTEN inact mut Akt2 Inhibitor
PTEN Y225* Akt2 Inhibitor
PTEN Y27C Akt2 Inhibitor
PTEN K66fs Akt1 Inhibitor
PTEN C136Y Akt1 Inhibitor
PTEN E106* Akt1 Inhibitor
PTEN A121E Akt Inhibitor (Pan)
PTEN V290Sfs*8 Akt2 Inhibitor
PTEN C124N Akt2 Inhibitor
PTEN L108H Akt Inhibitor (Pan)
PTEN R14G Akt1 Inhibitor
PTEN D326N Akt1 Inhibitor
PTEN I67K Akt2 Inhibitor
PTEN C124W Akt Inhibitor (Pan)
PTEN D162Y Akt1 Inhibitor
PTEN G127E Akt2 Inhibitor
PTEN Y155fs Akt1 Inhibitor
PTEN L140F Akt2 Inhibitor
PTEN S229* Akt Inhibitor (Pan)
PTEN R173H Akt Inhibitor (Pan)
PTEN Y88D Akt2 Inhibitor
PTEN Y188* Akt1 Inhibitor
PTEN R173H Akt1 Inhibitor
PTEN H118fs Akt2 Inhibitor
PTEN R130P Akt Inhibitor (Pan)
PTEN L70V Akt1 Inhibitor
PTEN D92A Akt2 Inhibitor
PTEN F56C Akt1 Inhibitor
PTEN R159F Akt Inhibitor (Pan)
PTEN G132del Akt1 Inhibitor
PTEN I122L Akt Inhibitor (Pan)
PTEN K267* Akt2 Inhibitor
PTEN L152R Akt Inhibitor (Pan)
PTEN V45del Akt2 Inhibitor
PTEN G293fs Akt2 Inhibitor
PTEN V119G Akt Inhibitor (Pan)
PTEN K13* Akt Inhibitor (Pan)
PTEN Q298* Akt Inhibitor (Pan)
PTEN Y155H Akt2 Inhibitor
PTEN Y68N Akt2 Inhibitor
PTEN L265fs Akt Inhibitor (Pan)
PTEN R130* Akt1 Inhibitor
PTEN D326Y Akt1 Inhibitor
PTEN A72fs Akt Inhibitor (Pan)
PTEN V249E Akt1 Inhibitor
PTEN V290fs Akt Inhibitor (Pan)
PTEN R130G Akt Inhibitor (Pan)
PTEN L70R Akt2 Inhibitor
PTEN E242* Akt Inhibitor (Pan)
PTEN D324del Akt2 Inhibitor
PTEN L182P Akt2 Inhibitor
PTEN K237fs Akt2 Inhibitor
PTEN L57fs Akt2 Inhibitor
PTEN Y174* Akt2 Inhibitor
PTEN Y240* Akt Inhibitor (Pan)
PTEN Y336* Akt Inhibitor (Pan)
PTEN E284* Akt2 Inhibitor
PTEN E285* Akt Inhibitor (Pan)
PTEN V175E Akt Inhibitor (Pan)
PTEN L70R Akt1 Inhibitor
PTEN I101N Akt Inhibitor (Pan)
PTEN Q261* Akt2 Inhibitor
PTEN E288fs Akt1 Inhibitor
PTEN Y178* Akt2 Inhibitor
PTEN R159S Akt2 Inhibitor
PTEN L108P Akt1 Inhibitor
PTEN G165* Akt1 Inhibitor
PTEN E18* Akt2 Inhibitor
PTEN R189* Akt1 Inhibitor
PTEN C124fs Akt1 Inhibitor
PTEN R335L Akt1 Inhibitor
PTEN Q17* Akt1 Inhibitor
PTEN L23F Akt Inhibitor (Pan)
PTEN K66fs Akt Inhibitor (Pan)
PTEN N48K Akt2 Inhibitor
PTEN K6del Akt2 Inhibitor
PTEN K125N Akt1 Inhibitor
PTEN D162del Akt Inhibitor (Pan)
PTEN S287* Akt1 Inhibitor
PTEN S227F Akt1 Inhibitor
PTEN L70fs Akt1 Inhibitor
PTEN D326* Akt1 Inhibitor
PTEN G127E Akt Inhibitor (Pan)
PTEN Y68H Akt1 Inhibitor
PTEN G251D Akt2 Inhibitor
PTEN Y65S Akt Inhibitor (Pan)
PTEN F347L Akt1 Inhibitor
PTEN R142P Akt Inhibitor (Pan)
PTEN K125* Akt1 Inhibitor
PTEN C124N Akt1 Inhibitor
PTEN F56C Akt2 Inhibitor
PTEN L182fs Akt1 Inhibitor
PTEN N48K Akt1 Inhibitor
PTEN Q245* Akt Inhibitor (Pan)
PTEN G143fs Akt Inhibitor (Pan)
PTEN Q245* Akt2 Inhibitor
PTEN N48S Akt1 Inhibitor
PTEN Q17* Akt Inhibitor (Pan)
PTEN P339L Akt Inhibitor (Pan)
PTEN Y76* Akt Inhibitor (Pan)
PTEN I67K Akt1 Inhibitor
PTEN K221* Akt1 Inhibitor
PTEN Y176del Akt1 Inhibitor
PTEN Y46D Akt1 Inhibitor
PTEN R142W Akt2 Inhibitor
PTEN Y225* Akt Inhibitor (Pan)
PTEN G44D Akt2 Inhibitor
PTEN D92V Akt2 Inhibitor
PTEN H123D Akt Inhibitor (Pan)
PTEN K125E Akt2 Inhibitor
PTEN E284fs Akt1 Inhibitor
PTEN F154L Akt2 Inhibitor
PTEN G165R Akt1 Inhibitor
PTEN Y188del Akt2 Inhibitor
PTEN G251C Akt2 Inhibitor
PTEN S302Afs*5 Akt2 Inhibitor
PTEN K183Ifs*15 Akt1 Inhibitor
PTEN Y27S Akt1 Inhibitor
PTEN F145* Akt1 Inhibitor
PTEN K260* Akt1 Inhibitor
PTEN C124S Akt1 Inhibitor
PTEN C83* Akt1 Inhibitor
PTEN L108R Akt1 Inhibitor
PTEN I101F Akt Inhibitor (Pan)
PTEN C136R Akt2 Inhibitor
PTEN V166Sfs*14 Akt Inhibitor (Pan)
PTEN G127N Akt Inhibitor (Pan)
PTEN N276S Akt Inhibitor (Pan)
PTEN I8Dfs*3 Akt Inhibitor (Pan)
PTEN del Akt Inhibitor (Pan)
PTEN G129E Akt2 Inhibitor
PTEN Q171* Akt1 Inhibitor
PTEN R130P Akt2 Inhibitor
PTEN E99* Akt Inhibitor (Pan)
PTEN V166G Akt Inhibitor (Pan)
PTEN L182P Akt1 Inhibitor
PTEN R130K Akt Inhibitor (Pan)
PTEN Y240* Akt2 Inhibitor
PTEN F271S Akt Inhibitor (Pan)
PTEN R159F Akt1 Inhibitor
PTEN D24G Akt1 Inhibitor
PTEN L57S Akt Inhibitor (Pan)
PTEN C250fs Akt Inhibitor (Pan)
PTEN K128T Akt1 Inhibitor
PTEN R74Dfs*25 Akt Inhibitor (Pan)
PTEN N184Efs*16 Akt Inhibitor (Pan)
PTEN Y155N Akt1 Inhibitor
PTEN L325F Akt Inhibitor (Pan)
PTEN D331fs Akt1 Inhibitor
PTEN I122fs Akt2 Inhibitor
PTEN R159S Akt1 Inhibitor
PTEN S170R Akt Inhibitor (Pan)
PTEN T319fs Akt2 Inhibitor
PTEN A126D Akt2 Inhibitor
PTEN L193fs Akt1 Inhibitor
PTEN K13Q Akt2 Inhibitor
PTEN G20E Akt Inhibitor (Pan)
PTEN V255A Akt Inhibitor (Pan)
PTEN A34P Akt Inhibitor (Pan)
PTEN S59P Akt2 Inhibitor
PTEN D92H Akt Inhibitor (Pan)
PTEN R161G Akt1 Inhibitor
PTEN W111S Akt1 Inhibitor
PTEN L108P Akt Inhibitor (Pan)
PTEN E150* Akt Inhibitor (Pan)
PTEN N323fs Akt1 Inhibitor
PTEN G230* Akt1 Inhibitor
PTEN G230* Akt2 Inhibitor
PTEN L193P Akt Inhibitor (Pan)
PTEN L57S Akt1 Inhibitor
PTEN T167N Akt2 Inhibitor
PTEN G36* Akt Inhibitor (Pan)
PTEN H61D Akt1 Inhibitor
PTEN R233* Akt2 Inhibitor
PTEN Q219* Akt2 Inhibitor
PTEN C105F Akt2 Inhibitor
PTEN V217D Akt Inhibitor (Pan)
PTEN Q298fs Akt1 Inhibitor
PTEN P38R Akt Inhibitor (Pan)
PTEN C124N Akt Inhibitor (Pan)
PTEN D331Tfs*13 Akt2 Inhibitor
PTEN K330* Akt Inhibitor (Pan)
PTEN Y174N Akt1 Inhibitor
PTEN E157* Akt2 Inhibitor
PTEN E157G Akt1 Inhibitor
PTEN F257L Akt Inhibitor (Pan)
PTEN E201* Akt2 Inhibitor
PTEN R142W Akt1 Inhibitor
PTEN R15K Akt1 Inhibitor
PTEN R130* Akt Inhibitor (Pan)
PTEN S227F Akt Inhibitor (Pan)
PTEN V290* Akt1 Inhibitor
PTEN Y177* Akt2 Inhibitor
PTEN R74Dfs*25 Akt2 Inhibitor
PTEN Y16D Akt Inhibitor (Pan)
PTEN E291* Akt Inhibitor (Pan)
PTEN K6* Akt Inhibitor (Pan)
PTEN P38T Akt1 Inhibitor
PTEN R335L Akt2 Inhibitor
PTEN I101T Akt2 Inhibitor
PTEN K60fs Akt Inhibitor (Pan)
PTEN V119fs Akt1 Inhibitor
PTEN D326Y Akt2 Inhibitor
PTEN L265fs Akt2 Inhibitor
PTEN T319fs Akt1 Inhibitor
PTEN F21A Akt2 Inhibitor
PTEN K237fs Akt Inhibitor (Pan)
PTEN N340fs Akt1 Inhibitor
PTEN L152P Akt1 Inhibitor
PTEN N212Kfs*10 Akt1 Inhibitor
PTEN Q219* Akt Inhibitor (Pan)
PTEN H61R Akt2 Inhibitor
PTEN N292fs Akt1 Inhibitor
PTEN V166E Akt Inhibitor (Pan)
PTEN N276S Akt1 Inhibitor
PTEN R335* Akt2 Inhibitor
PTEN K6E Akt Inhibitor (Pan)
PTEN N340fs Akt Inhibitor (Pan)
PTEN R55fs Akt Inhibitor (Pan)
PTEN K62R Akt Inhibitor (Pan)
PTEN Y27S Akt Inhibitor (Pan)
PTEN K13* Akt2 Inhibitor
PTEN V290fs Akt1 Inhibitor
PTEN K128Q Akt Inhibitor (Pan)
PTEN R130Q Akt2 Inhibitor
PTEN R161G Akt2 Inhibitor
PTEN C124L Akt Inhibitor (Pan)
PTEN Q298* Akt2 Inhibitor
PTEN Y174* Akt Inhibitor (Pan)
PTEN A126P Akt2 Inhibitor
PTEN A126V Akt1 Inhibitor
PTEN H61D Akt Inhibitor (Pan)
PTEN V54fs Akt2 Inhibitor
PTEN K62R Akt1 Inhibitor
PTEN H93D Akt Inhibitor (Pan)
PTEN K6del Akt Inhibitor (Pan)
PTEN P95S Akt Inhibitor (Pan)
PTEN L247Sfs*6 Akt1 Inhibitor
PTEN G251C Akt Inhibitor (Pan)
PTEN A39P Akt2 Inhibitor
PTEN E157G Akt Inhibitor (Pan)
PTEN H93Q Akt2 Inhibitor
PTEN D22E Akt2 Inhibitor
PTEN C71Y Akt Inhibitor (Pan)
PTEN K254* Akt Inhibitor (Pan)
PTEN L182fs Akt Inhibitor (Pan)
PTEN G251D Akt1 Inhibitor
PTEN N94I Akt2 Inhibitor
PTEN F90S Akt Inhibitor (Pan)
PTEN Q171* Akt2 Inhibitor
PTEN E291* Akt1 Inhibitor
PTEN I135K Akt Inhibitor (Pan)
PTEN K13E Akt1 Inhibitor
PTEN E284fs Akt Inhibitor (Pan)
PTEN N276K Akt2 Inhibitor
PTEN M134R Akt1 Inhibitor
PTEN L345Q Akt2 Inhibitor
PTEN R159L Akt Inhibitor (Pan)
PTEN D326Y Akt Inhibitor (Pan)
PTEN F271S Akt2 Inhibitor
PTEN G230* Akt Inhibitor (Pan)
PTEN K269* Akt2 Inhibitor
PTEN D24H Akt Inhibitor (Pan)
PTEN L70P Akt1 Inhibitor
PTEN V45del Akt1 Inhibitor
PTEN Y176* Akt2 Inhibitor
PTEN I28N Akt Inhibitor (Pan)
PTEN K102fs Akt2 Inhibitor
PTEN V217G Akt2 Inhibitor
PTEN L247Sfs*6 Akt Inhibitor (Pan)
PTEN T319del Akt Inhibitor (Pan)
PTEN Q17Kfs*7 Akt Inhibitor (Pan)
PTEN L247Sfs*6 Akt2 Inhibitor
PTEN I135R Akt Inhibitor (Pan)
PTEN M198R Akt2 Inhibitor
PTEN D92G Akt Inhibitor (Pan)
PTEN S385* Akt1 Inhibitor
PTEN H93D Akt2 Inhibitor
PTEN L318fs Akt Inhibitor (Pan)
PTEN S59* Akt1 Inhibitor
PTEN S229* Akt2 Inhibitor
PTEN Y155C Akt Inhibitor (Pan)
PTEN L152P Akt Inhibitor (Pan)
PTEN T319del Akt2 Inhibitor
PTEN G293fs Akt Inhibitor (Pan)
PTEN V53E Akt2 Inhibitor
PTEN L247* Akt1 Inhibitor
PTEN P339L Akt2 Inhibitor
PTEN Y138L Akt Inhibitor (Pan)
PTEN Q219* Akt1 Inhibitor
PTEN Y65C Akt Inhibitor (Pan)
PTEN A151P Akt Inhibitor (Pan)
PTEN R15I Akt2 Inhibitor
PTEN G44D Akt1 Inhibitor
PTEN V275G Akt2 Inhibitor
PTEN Y65* Akt1 Inhibitor
PTEN V45del Akt Inhibitor (Pan)
PTEN D92H Akt1 Inhibitor
PTEN A34D Akt1 Inhibitor
PTEN R234* Akt Inhibitor (Pan)
PTEN H123L Akt2 Inhibitor
PTEN N117S Akt1 Inhibitor
PTEN D326N Akt Inhibitor (Pan)
PTEN D331fs Akt Inhibitor (Pan)
PTEN H123Q Akt Inhibitor (Pan)
PTEN D92V Akt Inhibitor (Pan)
PTEN S170I Akt1 Inhibitor
PTEN R161G Akt Inhibitor (Pan)
PTEN E18* Akt1 Inhibitor
PTEN R173fs Akt2 Inhibitor
PTEN Y65S Akt2 Inhibitor
PTEN K6I Akt1 Inhibitor
PTEN L23V Akt Inhibitor (Pan)
PTEN L57W Akt2 Inhibitor
PTEN I135R Akt1 Inhibitor
PTEN F341V Akt2 Inhibitor
PTEN C124L Akt1 Inhibitor
PTEN W111* Akt Inhibitor (Pan)
PTEN Y68C Akt2 Inhibitor
PTEN P95L Akt2 Inhibitor
PTEN Y240* Akt1 Inhibitor
PTEN S10del Akt2 Inhibitor
PTEN Y46D Akt2 Inhibitor
PTEN Q245* Akt1 Inhibitor
PTEN D252Y Akt2 Inhibitor
PTEN V275* Akt Inhibitor (Pan)
PTEN L70R Akt Inhibitor (Pan)
PTEN Q17Kfs*7 Akt2 Inhibitor
PTEN D162del Akt1 Inhibitor
PTEN M35V Akt1 Inhibitor
PTEN G36E Akt1 Inhibitor
PTEN F56fs Akt1 Inhibitor
PTEN F257L Akt2 Inhibitor
PTEN G36R Akt Inhibitor (Pan)
PTEN T167A Akt1 Inhibitor
PTEN A34D Akt Inhibitor (Pan)
PTEN H93P Akt Inhibitor (Pan)
PTEN D24Y Akt Inhibitor (Pan)
PTEN R234* Akt1 Inhibitor
PTEN V255A Akt2 Inhibitor
PTEN R233* Akt1 Inhibitor
PTEN Y27fs Akt Inhibitor (Pan)
PTEN M134T Akt Inhibitor (Pan)
PTEN T348I Akt Inhibitor (Pan)
PTEN G293* Akt2 Inhibitor
PTEN L152R Akt2 Inhibitor
PTEN C218* Akt1 Inhibitor
PTEN K125N Akt Inhibitor (Pan)
PTEN A121P Akt1 Inhibitor
PTEN R130L Akt2 Inhibitor
PTEN G132del Akt2 Inhibitor
PTEN R173P Akt1 Inhibitor
PTEN A34P Akt2 Inhibitor
PTEN V119G Akt1 Inhibitor
PTEN R159S Akt Inhibitor (Pan)
PTEN A126S Akt2 Inhibitor
PTEN N184Efs*16 Akt2 Inhibitor
PTEN S302Afs*5 Akt1 Inhibitor
PTEN R15K Akt2 Inhibitor
PTEN K6I Akt2 Inhibitor
PTEN R159F Akt2 Inhibitor
PTEN M134R Akt Inhibitor (Pan)
PTEN V158fs Akt2 Inhibitor
PTEN L247_P248del Akt2 Inhibitor
PTEN F347L Akt2 Inhibitor
PTEN K263* Akt Inhibitor (Pan)
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References