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PMID | (25583779) | ||||||||||||
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Title | IDH1 inhibitor shows promising early results. | ||||||||||||
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Abstract Text | The experimental drug AG-120, which inhibits mutant IDH1, showed promising results in a phase I trial in patients with relapsed or refractory acute myeloid leukemia. |
Molecular Profile | Treatment Approach |
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IDH1 R132I | IDH1 Inhibitor |
IDH1 R132L | IDH1 Inhibitor |
IDH1 R132C | IDH1 Inhibitor |
IDH1 R132V | IDH1 Inhibitor |
IDH1 R132X | IDH1 Inhibitor |
IDH1 R132S | IDH1 Inhibitor |
IDH1 R132P | IDH1 Inhibitor |
IDH1 R132H | IDH1 Inhibitor |
Gene Name | Source | Synonyms | Protein Domains | Gene Description | Gene Role |
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Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
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Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
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Gene | Variant | Impact | Protein Effect | Variant Description | Associated with drug Resistance |
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Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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