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Authors | Donald C. Porter, Mengqian Chen, Jiaxin Liang et al. | ||||||||||||
Title | Targeting tumor microenvironment with selective small-molecule inhibitors of CDK8/19 | ||||||||||||
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URL | http://cancerres.aacrjournals.org/content/75/1_Supplement/PR08.abstract | ||||||||||||
Abstract Text | Cancer Res January 1, 2015 75; PR08 |
Molecular Profile | Treatment Approach |
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Gene Name | Source | Synonyms | Protein Domains | Gene Description | Gene Role |
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Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
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Senexin B | CDK8 Inhibitor 5 | Senexin B is a protein kinase inhibitor of CDK8 and the CDK8 paralog, CDK19, which may result in tumor growth inhibition and enhance the effects of chemotherapeutic agents (Cancer Res January 1, 2015 75; PR08, PMID: 31717492, PMID: 28147342). |
Gene | Variant | Impact | Protein Effect | Variant Description | Associated with drug Resistance |
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Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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