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Ref Type
PMID
Authors Donald C. Porter, Mengqian Chen, Jiaxin Liang et al.
Title Targeting tumor microenvironment with selective small-molecule inhibitors of CDK8/19
Journal The Journal of Cancer Research
Vol
Issue
Date
URL http://cancerres.aacrjournals.org/content/75/1_Supplement/PR08.abstract
Abstract Text Cancer Res January 1, 2015 75; PR08

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Senexin B Senexin B 1 0
Drug Name Trade Name Synonyms Drug Classes Drug Description
Senexin B CDK8 Inhibitor 3 Senexin B is a protein kinase inhibitor of CDK8 and the CDK8 paralog, CDK19, which may result in tumor growth inhibition and enhance the effects of chemotherapeutic agents (Cancer Res January 1, 2015 75; PR08, PMID: 31717492, PMID: 28147342).
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown triple-receptor negative breast cancer not applicable Senexin B Preclinical - Cell line xenograft Actionable In a preclinical study, Senexin B prevented tumor growth and enhanced the effects of Adriamycin (doxorubicin) in cell line xenograft models of triple-receptor negative breast cancer (Cancer Res January 1, 2015 75; PR08). detail...