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Ref Type
PMID
Authors Alex A. Adjei, Patricia LoRusso, Antoni Ribas, Jeffrey Alan Sosman, Anna C. Pavlick, Grace K. Dy, Xiaofei Zhou, Esha A. Gangolli, Russell M Walker, Michelle Kneissl, Stephanie Faucette, Rachel Neuwirth, Viviana Bozon
Title Phase I, dose-escalation study of the investigational drug TAK-733, an oral MEK inhibitor, in patients (pts) with advanced solid tumors.
Journal
Vol
Issue
Date
URL http://meetinglibrary.asco.org/content/112399-132
Abstract Text J Clin Oncol 31, 2013 (suppl; abstr 2528)

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown Advanced Solid Tumor not applicable TAK-733 Phase I Actionable In a Phase I clinical trial, TAK-733 demonstrated safety and some preliminary efficacy in patients with advanced solid tumors with partial response in 5% (2/41) and stable disease in 37% (15/41) of patients (PMID: 27650277). 27650277 detail...