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Ref Type
PMID
Authors Ana Oaknin, Anne Floquet, Christophe Le Tourneau, Isabelle Laure Ray-Coquard, Florence Joly, Manuel Hidalgo, Alexandra Leary, Oliver Krieter, Angelika Lahr, Simona Rossomanno, Katharina Lechner, Tapan Nayak, Christophe Boetsch, Grozdana Rasuo, Anthony Mor
Title Single agent vanucizumab (RO5520985) for platinum (Pt)-resistant recurrent ovarian cancer (OC): Results from a single arm extension phase of the phase I FIH study.
Journal J Clin Oncol
Vol
Issue
Date
URL http://meetinglibrary.asco.org/content/149637-156
Abstract Text J Clin Oncol 33, 2015 (suppl; abstr 5549)

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown ovarian cancer not applicable RO5520985 Phase I Actionable In a Phase I clinical trial, Vanucizumab (RO5520985) treatment resulted in partial response in 29% (12/41) and stable disease in 54% of (22/41) platinum (Pt)- resistant/refractory epithelial ovarian cancer patients (J Clin Oncol 33, 2015 (suppl; abstr 5549)). detail...