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Ref Type Journal Article
PMID (18536917)
Authors Mittendorf EA, Holmes JP, Ponniah S, Peoples GE
Title The E75 HER2/neu peptide vaccine.
Journal Vol Issue Date Pages Journal Short Title
Cancer immunology, immunotherapy : CII 57 10 2008 Oct 1511-21 Cancer Immunol Immunother
URL
Abstract Text E75 (HER2/neu 369-377) is an immunogenic peptide from the HER2/neu protein which is overexpressed in many breast cancer patients. A large amount of preclinical work and a small number of Phase I trials have been completed evaluating the vaccine potential of the E75 peptide mixed with an immunoadjuvant. Our group has performed two concurrent E75 + GM-CSF Phase II trials in node-positive and node-negative disease-free breast cancer patients. These trials, totaling 186 patients, were designed to assess the ability of the E75 vaccine to prevent disease recurrence in these high risk patients. In this review article, we discuss the safety of the vaccine, the immunologic response to the peptide, and most importantly, the potential clinical benefit of the vaccine. The recurrence rate, mortality associated with recurrence, and the distribution of recurrences are presented and discussed. Additionally, the lessons learned from these trials to include optimal dosing and the need for booster inoculations are addressed. We also present data exploring possible explanations and mechanisms behind the potential clinical utility of this simple single epitope vaccine. Finally, we present some of the future directions for our Cancer Vaccine Development Program assessing multi-epitope peptide vaccines and combination immunotherapies.

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
E75 E75 0 3
Drug Name Trade Name Synonyms Drug Classes Drug Description
E75 NeuVax|nelipepimut-S HER2 (ERBB2) Vaccine 13 NeuVax (E75) is a HER2-derived peptide vaccine that induces an anti-HER2 immune response, potentially resulting in decreased tumor recurrence (PMID: 18536917, PMID: 24907636).
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References