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Ref Type
PMID
Authors Byoung Heon Kang
Title Novel in vivo pan-Hsp90 family protein inhibitor, Panvotinib-401, showed potent anticancer activities without HSF1 activation
Journal
Vol
Issue
Date
URL http://www.abstractsonline.com/Plan/ViewAbstract.aspx?mID=4017&sKey=d0cbfd99-0744-49e4-a827-562c416014d8&cKey=5b87c7e4-79ec-456c-9ca0-037f038f5114&mKey=1d10d749-4b6a-4ab3-bcd4-f80fb1922267
Abstract Text

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Panvotinib-401 Panvotinib-401 1 0
Drug Name Trade Name Synonyms Drug Classes Drug Description
Panvotinib-401 HSP90 Inhibitor 35 Panvotinib-401 is a small molecule Hsp90 inhibitor that is mitochondrial inner membrane-permeable, resulting in cancer cell toxicity (AACR, Cancer Res: April 2016; Volume 57, Abstract #3896).
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown Advanced Solid Tumor not applicable Panvotinib-401 Preclinical Actionable In a preclinical study, Panvotinib-401 demonstrated cancer-selective cytotoxicity in transformed cell lines in culture (AACR, Cancer Res: April 2016; Volume 57, Abstract #3896). detail...