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Ref Type
PMID
Authors David Michael Hyman, Ben Tran, Jesus Corral Jaime, Elena Garralda, Jean-Pascal H. Machiels, Jan H. M. Schellens, Phillipe Bedard, Mario Campone, Philippe Cassier, John Sarantopoulos, Ulka N. Vaishampayan, Rashmi Chugh, Amit Mahipal et. al.
Title Phase Ib study of BGJ398 in combination with BYL719 in patients (pts) with select advanced solid tumors.
Journal J Clin Oncol
Vol
Issue
Date
URL http://abstracts.asco.org/176/AbstView_176_164336.html
Abstract Text J Clin Oncol 34, 2016 (suppl; abstr 2500)

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR3 - TACC3 transitional cell carcinoma predicted - sensitive Alpelisib + Infigratinib Phase I Actionable In a Phase Ib trial, Infigratinib (BGJ398) and Alpelisib (BYL719) combination treatment resulted in partial response and a complete shrinkage of target lesions lasting 4 months in one urothelial carcinoma patient harboring a FGFR3-TACC3 fusion (J Clin Oncol 34, 2016 (suppl; abstr 2500)). detail...
Unknown unknown Advanced Solid Tumor not applicable Alpelisib + Infigratinib Phase I Actionable In a Phase Ib trial, Infigratinib (BGJ398) and Alpelisib (BYL719) combination treatment resulted in partial response in 25% (8/32) of patients with advanced solid tumors, including urothelial, head and neck, melanoma, and anal cancer (J Clin Oncol 34, 2016 (suppl; abstr 2500)). detail...