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Ref Type
PMID
Authors Robert Hugh Jones, David Alan Anthoney, Robert J. Jones, Simon J. Crabb, Syed A. Hussain, Alison J. Birtle, Pavlina Spiliopoulou, Timothy Robinson, Margaret Knowles, Lyndall McLellan, Hazel Jones, Zoe Boylan, Donal Landers, Kwame Atuah et al
Title FIESTA: a Phase Ib and pharmacokinetic trial of AZD4547 in combination with gemcitabine and cisplatin.
Journal J Clin Oncol
Vol
Issue
Date
URL http://meetinglibrary.asco.org/content/164872-176
Abstract Text J Clin Oncol 34, 2016 (suppl; abstr 4521)

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown urinary bladder cancer not applicable AZD4547 + Cisplatin + Gemcitabine Phase I Actionable In a Phase I trial, AZD4547 in combination with Platinol (cisplatin) and Gemzar (gemcitabine) demonstrated safety and preliminary efficacy in bladder cancer patients (J Clin Oncol 34, 2016 (suppl; abstr 4521)). detail...