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Ref Type
Authors May Thet Cho, Dean Lim, Timothy W. Synold, Paul Henry Frankel, Lucille A. Leong, Joseph Chao, Vincent M. Chung, Yuan Chen, Stephen Sentovich, Eloise Luevanos, Marwan Fakih;
Title A phase I study of MEK162 and FOLFOX in chemotherapy-resistant metastatic colorectal cancer.
Abstract Text J Clin Oncol 34, 2016 (suppl; abstr 2544)


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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown colorectal cancer not applicable Binimetinib + Fluorouracil + Leucovorin + Oxaliplatin Phase I Actionable In a Phase I clinical trial, the combination of Binimetinib (MEK162) and FOLFOX chemotherapy demonstrated manageable toxicity and preliminary efficacy in metastatic colorectal cancer patients with chemotherapy resistance (J Clin Oncol 34, 2016 (suppl; abstr 2544)). detail...