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Ref Type
PMID
Authors Wan-Ching Yen, Marcus M. Fischer, Jalpa Shah, Jie Wei, Jennifer Cain, Pete Yeung, Lucia Beviglia, Belinda Cancilla, Ann Kapoun, John Lewicki, Austin Gurney, Timothy Hoey
Title Anti-DLL4 (demcizumab) inhibits tumor growth and reduces cancer stem cell frequency in patient-derived ovarian cancer xenografts.
Journal Cancer Res
Vol
Issue
Date
URL http://cancerres.aacrjournals.org/content/73/8_Supplement/3725.short
Abstract Text Cancer Res 2013;73(8 Suppl):Abstract nr 3725

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown ovarian cancer not applicable Demcizumab Preclinical - Pdx Actionable In a preclinical study, Demcizumab (OMP-21M18) inhibited tumor growth in patient-derived xenograft (PDX) models of ovarian cancer (Cancer Res 2013;73(8 Suppl):Abstract nr 3725). detail...
Unknown unknown ovarian cancer not applicable Demcizumab + Paclitaxel Preclinical - Pdx Actionable In a preclinical study, Demcizumab (OMP-21M18) and Taxol (paclitaxel) combination treatment inhibited tumor growth and suppressed cancer stem cells in patient-derived xenograft models of ovarian cancer (Cancer Res 2013;73(8 Suppl):Abstract nr 3725). detail...