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Ref Type
Authors R. S. Kristeleit, G. Shapiro, P. LoRusso, J.R. Infante, M.Flynn, M. R. Patel, S. M. Tolaney, J. F. Hilton, A. H. Calvert, H.i Giordano, J. D. Isaacson, J. Borrow, A. R. Allen, S. S. Jaw-Tsai, Howard A. Burris
Title A phase I dose-escalation and PK study of continuous oral rucaparib in patients with advanced solid tumors.
Abstract Text J Clin Oncol 31, 2013 (suppl; abstr 2585)


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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown Advanced Solid Tumor not applicable Rucaparib Phase I Actionable In a Phase I trial, Rubraca (rucaparib) was well-tolerated and demonstrated preliminary efficacy, with a disease control rate of 86% (6/7), in patients with advanced solid tumors (J Clin Oncol 31, 2013 (suppl; abstr 2585)). detail...