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Authors | Thomas T. Poulsen, Michael M. Grandal, Helle J. Jacobsen, Dorte S. Hansen, Trine Lindsted, Mikkel W. Pedersen, Ivan D. Horak, Michael Kragh and Johan Lantto | ||||||||||||
Title | Abstract 1219: Sym015, a novel antibody mixture targeting non-overlapping epitopes of MET, effectively inhibits growth of MET dependent tumors and overcomes resistance to a single monoclonal antibody | ||||||||||||
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URL | http://cancerres.aacrjournals.org/content/76/14_Supplement/1219 | ||||||||||||
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Molecular Profile | Treatment Approach |
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Gene Name | Source | Synonyms | Protein Domains | Gene Description | Gene Role |
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Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
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SYM015 | MET Antibody 28 | Sym015 is a mixture of two antibodies that bind to MET, leading to MET degradation and decreased growth of MET-dependent tumor cells (Cancer Res July 15 2016 (76) (14 Supplement) 1219, PMID: 29545332). |
Gene | Variant | Impact | Protein Effect | Variant Description | Associated with drug Resistance |
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Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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