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Ref Type
PMID
Authors Thomas T. Poulsen, Michael M. Grandal, Helle J. Jacobsen, Dorte S. Hansen, Trine Lindsted, Mikkel W. Pedersen, Ivan D. Horak, Michael Kragh and Johan Lantto
Title Abstract 1219: Sym015, a novel antibody mixture targeting non-overlapping epitopes of MET, effectively inhibits growth of MET dependent tumors and overcomes resistance to a single monoclonal antibody
URL http://cancerres.aacrjournals.org/content/76/14_Supplement/1219
Abstract Text

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
SYM015 SYM015 0 1
Drug Name Trade Name Synonyms Drug Classes Drug Description
SYM015 MET Antibody 28 Sym015 is a mixture of two antibodies that bind to MET, leading to MET degradation and decreased growth of MET-dependent tumor cells (Cancer Res July 15 2016 (76) (14 Supplement) 1219, PMID: 29545332).
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References