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Ref Type
PMID
Authors YG Garcia, A De Juan, C Mendiola, MP Barretina-Ginesta, A Prat, A Santaballa, I Bover, M Gil-Martin, A Manzano, MJ Rubio, M Romeo, C Arqueros, EG Martinez, AG Martin
Title Phase II randomized trial of neoadjuvant (NA) chemotherapy (CT) with or without bevacizumab (Bev) in advanced epithelial ovarian cancer (EOC)? (GEICO 1205/NOVA TRIAL).
Journal J Clin Oncol
Vol
Issue
Date
URL http://abstracts.asco.org/199/AbstView_199_186640.html
Abstract Text J Clin Oncol 35, 2017 (suppl; abstr 5508)

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown ovary epithelial cancer not applicable Bevacizumab + Carboplatin + Paclitaxel Phase II Actionable In a Phase II trial, addition of Avastin (bevacizumab) to neoadjuvant chemotherapy (Paraplatin (carboplatin) plus Taxol (paclitaxel)) did not improve complete macroscopic response rate (2/35 vs 2/33), or median progression free survival (20.4 vs 20.1 months) compared to control in patients with advanced epithelial ovarian cancer, but resulted in favorable rate of surgical feasibility (66.7 vs 88.6%) (J Clin Oncol 35, 2017 (suppl; abstr 5508)). detail...