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Ref Type
Authors Sayaka Ogi, Yasuhiro Aga, Kazuhiro Onuma, Hidetoshi Sunamoto, Takashi Matsushita, Ayumi Ogawa, Tohru Hasegawa, Shigeyuki Kono, Noriaki Iwase, Yasunori Tokunaga, Shigeru Ushiyama
Title Preclinical in vitro and in vivo evaluation of antitumor activity of UD-017, a novel selective and orally available CDK7 inhibitor, in colorectal cancer.
Journal J Clin Oncol
Abstract Text J Clin Oncol 35, 2017 (suppl; abstr e14085)


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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
UD-017 UD-017 2 0
Drug Name Trade Name Synonyms Drug Classes Drug Description
UD-017 CDK7 Inhibitor 13 UD-017 is a specific CDK7 inhibitor that induces cell cycle arrest and apoptosis in cancer cells (J Clin Oncol 35, 2017 (suppl; abstr e14085)).
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown colorectal cancer not applicable UD-017 Preclinical - Patient cell culture Actionable In a preclinical study, UD-017 inhibited growth of patient-derived colorectal cancer cells in culture (J Clin Oncol 35, 2017 (suppl; abstr e14085)). detail...
Unknown unknown colon carcinoma not applicable UD-017 Preclinical - Cell line xenograft Actionable In a preclinical study, UD-017 inhibited tumor growth in cell line xenograft models of colon carcinoma (J Clin Oncol 35, 2017 (suppl; abstr e14085)). detail...