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Authors | Sayaka Ogi, Yasuhiro Aga, Kazuhiro Onuma, Hidetoshi Sunamoto, Takashi Matsushita, Ayumi Ogawa, Tohru Hasegawa, Shigeyuki Kono, Noriaki Iwase, Yasunori Tokunaga, Shigeru Ushiyama | ||||||||||||
Title | Preclinical in vitro and in vivo evaluation of antitumor activity of UD-017, a novel selective and orally available CDK7 inhibitor, in colorectal cancer. | ||||||||||||
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URL | http://abstracts.asco.org/199/AbstView_199_194372.html | ||||||||||||
Abstract Text | J Clin Oncol 35, 2017 (suppl; abstr e14085) |
Molecular Profile | Treatment Approach |
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Gene Name | Source | Synonyms | Protein Domains | Gene Description | Gene Role |
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Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
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UD-017 | CDK7 Inhibitor 16 | UD-017 is a specific CDK7 inhibitor that induces cell cycle arrest and apoptosis in cancer cells (J Clin Oncol 35, 2017 (suppl; abstr e14085)). |
Gene | Variant | Impact | Protein Effect | Variant Description | Associated with drug Resistance |
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Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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