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Authors | Simon Rule, David Tucker, Anup Kalapur, Barbara Sarholz, Jürgen Scheele, Pier Luigi Zinzani | ||||||||||||
Title | Phase I/II, first in human trial of the Bruton’s tyrosine kinase inhibitor (BTKi) M7583 in patients with B cell malignancies. | ||||||||||||
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URL | http://abstracts.asco.org/199/AbstView_199_186701.html | ||||||||||||
Abstract Text | J Clin Oncol 35, 2017 (suppl; abstr e14101) |
Molecular Profile | Treatment Approach |
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Gene Name | Source | Synonyms | Protein Domains | Gene Description | Gene Role |
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Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
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Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
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M7583 | BTK inhibitor 36 | M7583 inhibits BTK, which may result in decreased tumor growth (J Clin Oncol 35, 2017 (suppl; abstr e14101)). |
Gene | Variant | Impact | Protein Effect | Variant Description | Associated with drug Resistance |
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Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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