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Authors | T. Jimbo, T. Taira , T. Komatsu , K. Kumazawa , N. Maeda , N. Haginoya , T. Suzuki. M. Ota, Y. Totoki, C. Wada, K. Inaki, T. Isoyama, M. Uno | ||||||||||||
Title | DS-1205b, a novel, selective, small-molecule inhibitor of AXL, delays the onset of resistance and overcomes acquired resistance to EGFR- TKIs in a human EGFR-mutant NSCLC (T790M-negative) xenograft model | ||||||||||||
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URL | http://www.poster-submission.com/esmo2017/visitors/eposter/34996 | ||||||||||||
Abstract Text | 395P |
Molecular Profile | Treatment Approach |
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Gene Name | Source | Synonyms | Protein Domains | Gene Description | Gene Role |
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Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
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DS-1205b | AXL Inhibitor 30 | DS-1205b inhibits AXL, which potentially results in decreased cell migration, and reduced tumor growth (Ann Oncol 2017, Vol 28, Suppl 5, Abstract #395P, PMID: 31497246). |
Gene | Variant | Impact | Protein Effect | Variant Description | Associated with drug Resistance |
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Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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