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Ref Type
Authors Vanessa Al-Rawi, Thorsten Laeufer, Katrin Glocker, Yvonne Heneka and Alexandra Matzke-Ogi
Title Abstract 4911: Allosteric inhibition of the Receptor Tyrosine Kinases c-MET, RON and VEGFR-2 via the co-receptor CD44v6 by the novel compound AMC303
Journal Cancer Research
Abstract Text Cancer Res 2017;77(13 Suppl):Abstract nr 4911


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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
AMC303 AMC303 is an allosteric inhibitor of CD44v6, the co-receptor of c-MET, RON, and VEGFR2, which may result in decreased cell invasion and migration, and tumor regression (Cancer Res 2017;77(13 Suppl):Abstract nr 4911).
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown Advanced Solid Tumor not applicable AMC303 Preclinical - Cell line xenograft Actionable In a preclinical study, AMC303 resulted in decreased cell invasion and migration in solid tumor cell lines in culture and tumor regression of metastatic lesions of the liver in xenograft models (Cancer Res 2017;77(13 Suppl):Abstract nr 4911). detail...