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NCT ID NCT03924856
Title Perioperative Pembrolizumab (MK-3475) Plus Neoadjuvant Chemotherapy Versus Perioperative Placebo Plus Neoadjuvant Chemotherapy for Cisplatin-eligible Muscle-invasive Bladder Cancer (MIBC) (MK-3475-866/KEYNOTE-866) (KEYNOTE-866)
Recruitment Recruiting
Gender both
Phase Phase III
Variant Requirements No
Sponsors Merck Sharp & Dohme Corp.

invasive bladder transitional cell carcinoma


Cisplatin + Gemcitabine + Pembrolizumab

Cisplatin + Gemcitabine

Age Groups: adult | senior
Covered Countries USA | ITA | FRA | ESP | DEU | CAN | BEL

Facility Status City State Zip Country Details
Scripps MD Anderson ( Site 0010) Recruiting La Jolla California 92037 United States Details
Providence Saint John's Health Center ( Site 0075) Recruiting Santa Monica California 90404 United States Details
Georgetown University Medical Center ( Site 0022) Active, not recruiting Washington District of Columbia 20007 United States Details
AdventHealth Orlando-AdventHealth Medical Group Hematology & Oncology at Orlando ( Site 0005) Active, not recruiting Orlando Florida 32804 United States Details
Parkview Cancer Institute ( Site 0077) Active, not recruiting Fort Wayne Indiana 46845 United States Details
Indiana University Melvin and Bren Simon Cancer Center ( Site 0004) Recruiting Indianapolis Indiana 46202 United States Details
Ochsner Medical Center ( Site 0049) Recruiting New Orleans Louisiana 70121 United States Details
New England Cancer Specialists ( Site 0070) Active, not recruiting Scarborough Maine 04074 United States Details
UMass Memorial Medical Center ( Site 0051) Recruiting Worcester Massachusetts 01655 United States Details
Henry Ford Hospital ( Site 0039) Active, not recruiting Detroit Michigan 48202 United States Details
Mercy Hospital Saint Louis ( Site 0064) Recruiting Saint Louis Missouri 63141 United States Details
Morristown Medical Center ( Site 0015) Recruiting Morristown New Jersey 07960 United States Details
UNM Comprehensive Cancer Center-Clinical Research Office ( Site 0045) Completed Albuquerque New Mexico 87106 United States Details
New York University Perlmutter Cancer Center ( Site 0008) Recruiting New York New York 10016 United States Details
University Hospitals Cleveland Medical Center ( Site 0038) Recruiting Cleveland Ohio 44106 United States Details
Oklahoma Cancer Specialists and Research Institute, LLC ( Site 0021) Recruiting Tulsa Oklahoma 74146 United States Details
Portland VA Medical Center ( Site 0084) Active, not recruiting Portland Oregon 97239 United States Details
Allegheny General Hospital ( Site 0048) Recruiting Pittsburgh Pennsylvania 15212 United States Details
MD Anderson Cancer Center ( Site 0063) Recruiting Houston Texas 77030 United States Details
Central Texas Veterans Healthcare System ( Site 0057) Completed Temple Texas 76504 United States Details
Inova Schar Cancer Institute ( Site 0007) Active, not recruiting Fairfax Virginia 22031 United States Details
Northwest Medical Specialties, PLLC ( Site 0061) Recruiting Puyallup Washington 98373 United States Details
Seattle Cancer Care Alliance/Univ of Washington Medical Center ( Site 0033) Recruiting Seattle Washington 98109 United States Details
Charleston Area Medical Center ( Site 0023) Active, not recruiting Charles Town West Virginia 25304 United States Details
Mid North Coast Cancer Institute ( Site 1256) Recruiting Port Macquarie New South Wales 2444 Australia Details
Southside Cancer Care Centre ( Site 1252) Completed Sydney New South Wales 2228 Australia Details
Cairns Base Hospital ( Site 1257) Completed Cairns Queensland 4870 Australia Details
Eastern Health ( Site 1255) Completed Box Hill Victoria 3128 Australia Details
Peninsula Health Frankston Hospital ( Site 1258) Recruiting Frankston Victoria 3199 Australia Details
UZ Brussel ( Site 0358) Recruiting Brussels Bruxelles-Capitale, Region De 1090 Belgium Details
Jessa Ziekenhuis ( Site 0360) Recruiting Hasselt Limburg 3500 Belgium Details
CHU UCL Namur Site de Godinne ( Site 0354) Recruiting Yvoir Namur 5530 Belgium Details
O.L.V. Ziekenhuis Aalst ( Site 0356) Recruiting Aalst Oost-Vlaanderen 9300 Belgium Details
AZ Maria Middelares Gent ( Site 0353) Recruiting Gent Oost-Vlaanderen 9000 Belgium Details
Tom Baker Cancer Centre ( Site 0100) Recruiting Calgary Alberta T2N 4N2 Canada Details
Nova Scotia Health Authority ( Site 0109) Completed Halifax Nova Scotia B3H 1V7 Canada Details
Kingston Health Sciences Centre ( Site 0103) Recruiting Kingston Ontario K7L 2V7 Canada Details
Lakeridge Health ( Site 0104) Recruiting Oshawa Ontario L1G 2B9 Canada Details
Sunnybrook Research Institute ( Site 0110) Recruiting Toronto Ontario M4N 3M5 Canada Details
Princess Margaret Cancer Centre ( Site 0107) Recruiting Toronto Ontario M5G 2M9 Canada Details
CIUSSS de l Est de L Ile de Montreal - Hopital Maisonneuve-Rosemont ( Site 0105) Recruiting Montreal Quebec H1T 2M4 Canada Details
Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus ( Site 0 Recruiting Quebec City Quebec G1J 1Z4 Canada Details
Herlev og Gentofte Hospital. ( Site 0402) Recruiting Herlev Hovedstaden 2730 Denmark Details
Rigshospitalet University Hospital ( Site 0401) Completed Kobenhavn Hovedstaden 2100 Denmark Details
Odense Universitetshospital ( Site 0403) Recruiting Odense Syddanmark 5000 Denmark Details
CHU de Bordeaux- Hopital Saint Andre ( Site 0456) Completed Bordeaux Aquitaine 33075 France Details
Centre Leon Berard ( Site 0465) Recruiting Lyon Auvergne 69373 France Details
Centre Francois Baclesse ( Site 0459) Recruiting Caen Calvados 14075 France Details
Centre Armoricain de Radiotherapie Imagerie medicale et Oncologie ( Site 0457) Recruiting Plerin Cotes-d Armor 22190 France Details
Hopital Foch ( Site 0483) Recruiting Suresnes Hauts-de-Seine 92150 France Details
CHU de Montpellier - Hopital Saint-Eloi ( Site 0469) Recruiting Montpellier Languedoc-Roussillon 34295 France Details
Institut de Cancerologie de l Ouest Site Paul Papin ( Site 0453) Recruiting Angers Maine-et-Loire 49000 France Details
Hopital Robert Schuman ( Site 0452) Recruiting Metz Moselle 57070 France Details
Centre Jean Perrin ( Site 0460) Recruiting Clermont-Ferrand Puy-de-Dome 63011 France Details
Clinique Victor Hugo ( Site 0463) Recruiting Le Mans Sarthe 72000 France Details
CHU de Rouen ( Site 0493) Recruiting Rouen Seine-Maritime 76031 France Details
Institut Sainte Catherine ( Site 0454) Recruiting Avignon Vaucluse 84918 France Details
Klinikum der Eberhard-Karls-Universitaet Tuebingen ( Site 0502) Recruiting Tuebingen Baden-Wurttemberg 72076 Germany Details
Universitaetsklinikum Erlangen ( Site 0505) Recruiting Erlangen Bayern 91058 Germany Details
Universitaetsklinikum Magdeburg A.o.R. ( Site 0516) Recruiting Magdeburg Sachsen-Anhalt 39120 Germany Details
Universitaetsklinikum Carl Gustav Carus ( Site 0519) Recruiting Dresden Sachsen 01307 Germany Details
Universitaetsklinikum Schleswig-Holstein-Campus Lubeck ( Site 0512) Recruiting Luebeck Schleswig-Holstein 23538 Germany Details
Charite Universitaetsmedizin Berlin ( Site 0515) Recruiting Berlin 10117 Germany Details
Vivantes Klinikum am Urban ( Site 0522) Recruiting Berlin 10967 Germany Details
Pecsi Tudomanyegyetem AOK ( Site 1009) Recruiting Pecs Baranya 7624 Hungary Details
SZTE Szent-Gyorgyi Albert Klinikai Kozpont ( Site 1010) Recruiting Szeged Csongrad 6720 Hungary Details
Jasz Nagykun Szolnok Megyei Hetenyi Geza Korhaz Rendelointezet ( Site 1002) Recruiting Szolnok Jasz-Nagykun-Szolnok 5004 Hungary Details
Bajcsy Zsilinszki Korhaz es Rendelointezet ( Site 1001) Recruiting Budapest 1106 Hungary Details
Debreceni Egyetem Klinikai Kozpont ( Site 1006) Recruiting Debrecen 4032 Hungary Details
Petz Aladar Megyei Oktato Korhaz ( Site 1012) Recruiting Gyor 9023 Hungary Details
Somogy Megyei Kaposi Mor Oktato Korhaz ( Site 1007) Completed Kaposvar 7400 Hungary Details
Cork University Hospital ( Site 0722) Recruiting Cork T12 DC4A Ireland Details
Tallaght University Hospital ( Site 0710) Recruiting Dublin D24 DH74 Ireland Details
University Hospital Waterford ( Site 0723) Active, not recruiting Waterford X91ER8E Ireland Details
Ha Emek Medical Center ( Site 0808) Recruiting Afula 1834111 Israel Details
Soroka Medical Center ( Site 0806) Recruiting Beer Sheva 8410101 Israel Details
Rambam Health Care Campus-Oncology Division ( Site 0802) Recruiting Haifa 3109601 Israel Details
Shaare Zedek Medical Center ( Site 0809) Recruiting Jerusalem 9103102 Israel Details
Hadassah Ein Kerem Medical Center ( Site 0810) Recruiting Jerusalem 9112001 Israel Details
Meir Medical Center ( Site 0803) Recruiting Kfar Saba 4428164 Israel Details
Rabin Medical Center ( Site 0804) Recruiting Petach Tikva 4941492 Israel Details
Sheba Medical Center ( Site 0801) Recruiting Ramat Gan 5265601 Israel Details
Sourasky Medical Center ( Site 0807) Recruiting Tel Aviv 6423906 Israel Details
Yitzhak Shamir Medical Center ( Site 0805) Recruiting Zerifin 7030001 Israel Details
Policlinico Gemelli di Roma ( Site 0558) Recruiting Roma Abruzzo 00168 Italy Details
Policlinico di Modena ( Site 0553) Recruiting Modena Emilia-Romagna 41124 Italy Details
A.O.U. Policlinico Vittorio Emanuele - Presidio Gaspare Rodolico ( Site 0559) Recruiting Catania 95123 Italy Details
Istituto Nazionale Studio e Cura dei Tumori ( Site 0551) Recruiting Milano 20133 Italy Details
Istituto Nazionale Per Lo Studio E La Cura Dei Tumori ( Site 0552) Recruiting Napoli 80131 Italy Details
Fondazione Salvatore Maugeri IRCCS. ( Site 0554) Completed Pavia 27100 Italy Details
Azienda Ospedaliera San Camillo Forlanini ( Site 0560) Recruiting Roma 00152 Italy Details
Azienda Ospedaliera Santa Maria Terni ( Site 0557) Recruiting Terni 05100 Italy Details
Hirosaki University Hospital ( Site 1502) Active, not recruiting Hirosaki Aomori 036-8563 Japan Details
National Cancer Center Hospital East ( Site 1504) Active, not recruiting Kashiwa Chiba 2778577 Japan Details
Ehime University Hospital ( Site 1508) Active, not recruiting Toon Ehime 791-0204 Japan Details
Sapporo Medical University Hospital ( Site 1501) Active, not recruiting Sapporo Hokkaido 060-8543 Japan Details
University of Tsukuba Hospital ( Site 1503) Active, not recruiting Tsukuba Ibaraki 305-8576 Japan Details
Yokosuka Kyosai Hospital ( Site 1509) Active, not recruiting Yokosuka Kanagawa 238-8558 Japan Details
Nara Medical University Hospital ( Site 1510) Active, not recruiting Kashihara Nara 634-8522 Japan Details
Saitama Medical University International Medical Center ( Site 1505) Active, not recruiting Hidaka Saitama 350-1298 Japan Details
Chiba Cancer Center ( Site 1506) Active, not recruiting Chiba 260-8717 Japan Details
Harasanshin Hospital ( Site 1515) Active, not recruiting Fukuoka 812-0033 Japan Details
Hiroshima City Hiroshima Citizens Hospital ( Site 1513) Active, not recruiting Hiroshima 730-8518 Japan Details
Nagano Municipal Hospital ( Site 1516) Active, not recruiting Nagano 381-8551 Japan Details
Osaka Metropolitan University Hospital ( Site 1512) Active, not recruiting Osaka 545-8586 Japan Details
Tokushima University Hospital ( Site 1514) Active, not recruiting Tokushima 770-8503 Japan Details
Tokyo Medical and Dental University Hospital ( Site 1517) Active, not recruiting Tokyo Japan Details
National Cancer Center ( Site 1354) Recruiting Goyang-si Kyonggi-do 10408 Korea, Republic of Details
Seoul National University Bundang Hospital ( Site 1356) Recruiting Seongnam-si Kyonggi-do 13620 Korea, Republic of Details
Korea University Anam Hospital ( Site 1351) Recruiting Seoul 02841 Korea, Republic of Details
Seoul National University Hospital ( Site 1352) Recruiting Seoul 03080 Korea, Republic of Details
Asan Medical Center ( Site 1355) Recruiting Seoul 05505 Korea, Republic of Details
Samsung Medical Center ( Site 1353) Recruiting Seoul 06351 Korea, Republic of Details
Centro de Urologia Avanzada del Noreste S.A. de C.V. ( Site 0254) Recruiting Monterrey Nuevo Leon 66269 Mexico Details
Investigacion Biomedica para el Desarrollo de Farmacos S.A. de C.V. ( Site 0300) Recruiting Aguascalientes 20010 Mexico Details
Centro Estatal de Cancerologia de Chihuahua ( Site 0253) Recruiting Chihuahua 31000 Mexico Details
Instituto Nacional de Cancerologia ( Site 0256) Recruiting Tlalpan 14080 Mexico Details
Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego ( Site 1062) Active, not recruiting Wroclaw Dolnoslaskie 50-556 Poland Details
Centrum Onkologii F. Lukaszczyka w Bydgoszczy ( Site 1068) Recruiting Bydgoszcz Kujawsko-pomorskie 85-796 Poland Details
Europejskie Centrum Zdrowia Otwock ( Site 1057) Recruiting Otwock Mazowieckie 05-400 Poland Details
Luxmed Onkologia sp. z o. o. ( Site 1051) Recruiting Warszawa Mazowieckie 01-748 Poland Details
Beskidzkie Centrum Onkologii im. Jana Pawla II ( Site 1060) Recruiting Bielsko-Biala Slaskie 43-300 Poland Details
Clinic of Bashkortostan State Medical University ( Site 0869) Suspended Ufa Baskortostan, Respublika 450081 Russian Federation Details
Ivanovo Regional Oncology Dispensary ( Site 0852) Suspended Ivanovo Ivanovskaya Oblast 153040 Russian Federation Details
Krasnoyarsk Regional Clinical Oncological Dispensary ( Site 0861) Suspended Krasnoyarsk Krasnoyarskiy Kray 660133 Russian Federation Details
Kursk Regional Clinical Oncology Dispensary ( Site 0854) Suspended Kursk Kurskaya Oblast 305524 Russian Federation Details
FSBI ""United Hospital with Polyclinic"" of the Administrative Department of the President of the Ru Suspended Moscow Moskva 119285 Russian Federation Details
Central Clinical Hospital with outpatient Clinic ( Site 0856) Suspended Moscow Moskva 121359 Russian Federation Details
Bayandin Murmansk Regional Clinical Hospital ( Site 0859) Completed Murmansk Murmanskaya Oblast 183057 Russian Federation Details
Volga District Medical Center Federal Medical and Biological Agency ( Site 0857) Suspended Nizhny Novgorod Nizhegorodskaya Oblast 603074 Russian Federation Details
Omsk Clinical Oncology Dispensary ( Site 0865) Suspended Omsk Omskaya Oblast 644013 Russian Federation Details
Leningrad Regional Oncology Center ( Site 0868) Suspended Saint Petersburg Sankt-Peterburg 188663 Russian Federation Details
Clinical Hospital Saint Luka ( Site 0867) Suspended St. Petersburg Sankt-Peterburg 194044 Russian Federation Details
Saratov State Medical University n.a. V.I.Razumovskiy ( Site 0866) Completed Saratov Saratovskaya Oblast 410012 Russian Federation Details
Hospital San Pedro de Alcantara ( Site 0654) Recruiting Caceres Extremadura 10003 Spain Details
H. de Gerona Dr. Josep Trueta ( Site 0651) Recruiting Girona Gerona 17007 Spain Details
Hospital Universitario Ramon y Cajal ( Site 0660) Recruiting Madrid Madrid, Comunidad De 28034 Spain Details
Hospital Universitario Quiron Madrid ( Site 0657) Recruiting Pozuelo de Alarcon Madrid, Comunidad De 28223 Spain Details
Instituto Valenciano de Oncologia - IVO ( Site 0662) Recruiting Valencia Valenciana, Comunitat 46009 Spain Details
Hospital del Mar ( Site 0653) Recruiting Barcelona 08003 Spain Details
Hospital Universitario San Carlos ( Site 0663) Recruiting Madrid 28040 Spain Details
Hospital Universitario La Paz ( Site 0661) Recruiting Madrid 28046 Spain Details
Hospital Nuestra Sra. de Valme ( Site 0658) Recruiting Sevilla 41014 Spain Details
Laenssjukhuset Ryhov ( Site 1205) Recruiting Jonkoping Jonkopings Lan 551 85 Sweden Details
Akademiska Sjukhuset ( Site 1201) Recruiting Uppsala Uppsala Lan 751 85 Sweden Details
Cancercentrum ( Site 1204) Active, not recruiting Umea Vasterbottens Lan 901 85 Sweden Details
Ramathibodi Hospital. ( Site 1451) Recruiting Bangkok Krung Thep Maha Nakhon 10400 Thailand Details
Faculty of Medicine Siriraj Hospital ( Site 1452) Active, not recruiting Bangkok Krung Thep Maha Nakhon 10700 Thailand Details
Maharaj Nakorn Chiangmai Hospital ( Site 1453) Recruiting Chiang Mai 50200 Thailand Details
Srinagarind Hospital ( Site 1454) Recruiting Khon Kaen 40002 Thailand Details
Hacettepe Universitesi Tıp Fakultesi ( Site 0911) Recruiting Ankara 06100 Turkey Details
Istanbul Universitesi Cerrahpasa Tip Fakultesi ( Site 0910) Recruiting Istanbul 34096 Turkey Details
TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi-oncology ( Site 0906) Recruiting Istanbul 34722 Turkey Details
Universitesi Pendik Egitim ve Arastirma Hastanesi ( Site 0901) Recruiting Istanbul 34899 Turkey Details
Necmettin Erbakan Universitesi Meram Tip Fakultesi Hastanesi ( Site 0909) Recruiting Konya 42080 Turkey Details
Sakarya Universitesi Tip Fakultesi ( Site 0913) Recruiting Sakarya 54290 Turkey Details
Karadeniz Teknik Universitesi Tip Fakultesi Farabi Hastanesi ( Site 0904) Recruiting Trabzon 61080 Turkey Details
Cherkasy Regional Oncology Dispensary ( Site 0959) Suspended Cherkasy Cherkaska Oblast 18009 Ukraine Details
MI Dnipr Regional Clinical Hospital named after I.I. Mechnikov ( Site 0963) Suspended Dnipropetrovsk Dnipropetrovska Oblast 49005 Ukraine Details
Regional Oncological Hospital ( Site 0956) Suspended Dnipro Dnipropetrovska Oblast 49055 Ukraine Details
Dnipropetrovsk City Multidiscipline Clinical Hosp. 4 of DRC ( Site 0951) Suspended Dnipro Dnipropetrovska Oblast 49102 Ukraine Details
Reg. Clinical Center of Urology and Nephrology n.a. V. I. Shapoval ( Site 0969) Suspended Kharkiv Kharkivska Oblast 61037 Ukraine Details
CNPE "Regional Center of Oncology" ( Site 0958) Suspended Kharkiv Kharkivska Oblast 61070 Ukraine Details
National Cancer Institute of the MoH of Ukraine ( Site 0962) Suspended Kyiv Kyivska Oblast 03022 Ukraine Details
Lviv Regional Clinical Hospital ( Site 0955) Suspended Lviv Lvivska Oblast 79000 Ukraine Details
Lviv State Oncology Regional Treatment and Diagnostic Center ( Site 0967) Suspended Lviv Lvivska Oblast 79000 Ukraine Details
Kyiv City Clinical Oncology Center ( Site 0960) Suspended Kyiv 03115 Ukraine Details
Aberdeen Royal Infirmary ( Site 0708) Recruiting Aberdeen Aberdeen City AB25 2ZN United Kingdom Details
Torbay Hospital ( Site 0704) Recruiting Torquay Devon TQ2 7AA United Kingdom Details
Kent and Canterbury Hospital ( Site 0709) Completed Canterbury England CT1 3NG United Kingdom Details
Lister Hospital ( Site 0715) Recruiting Stevenage Hertfordshire SG1 4AB United Kingdom Details
The Royal Marsden Foundation Trust ( Site 0702) Recruiting London London, City Of SW3 6JJ United Kingdom Details
Imperial College Healthcare NHS Trust ( Site 0721) Recruiting London London, City Of W6 8RF United Kingdom Details
Norfolk & Norwich University Hospital NHS Foundation Trust ( Site 0725) Recruiting Norwich Norfolk NR4 7UY United Kingdom Details
Royal Cornwall Hospital ( Site 0703) Recruiting Truro TR1 3LJ United Kingdom Details
*Shaded cells indicate that there was no data available from for the field