Disease Detail

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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
Unknown unknown Cisplatin + Gemcitabine + Sorafenib invasive bladder transitional cell carcinoma not applicable detail...
ERBB2 mutant Cisplatin + Gemcitabine + Sorafenib invasive bladder transitional cell carcinoma predicted - sensitive detail...
PIK3CA mutant Cisplatin + Gemcitabine + Sorafenib invasive bladder transitional cell carcinoma predicted - resistant detail...
AKT1 mutant Cisplatin + Gemcitabine + Sorafenib invasive bladder transitional cell carcinoma predicted - resistant detail...
Clinical Trial Phase Therapies Title Recruitment Status
NCT01326871 Phase Ib/II ALT-801 A Study of ALT-801 in Combination With Cisplatin and Gemcitabine in Muscle Invasive or Metastatic Urothelial Cancer Unknown status
NCT02546661 Phase I AZD9150 + Durvalumab Durvalumab + Selumetinib AZD4547 Durvalumab + Olaparib Durvalumab AZD4547 + Durvalumab Durvalumab + Vistusertib Adavosertib + Durvalumab Open-Label, Randomised, Multi-Drug, Biomarker-Directed, Phase 1b Study in Pts w/ Muscle Invasive Bladder Cancer (BISCAY) Active, not recruiting
NCT03244384 Phase III Pembrolizumab Pembrolizumab in Treating Patients With Locally Advanced Bladder Cancer Recruiting
NCT03534804 Phase II Cabozantinib + Pembrolizumab Cabozantinib Plus Pembrolizumab as First-Line Therapy for Cisplatin-Ineligible Advanced Urothelial Carcinoma (PemCab) Recruiting
NCT03558087 Phase II Cisplatin + Gemcitabine + Nivolumab Gemcitabine, Cisplatin, Plus Nivolumab in Patients With Muscle-invasive Bladder Cancer With Selective Bladder Sparing Recruiting
NCT03747419 Phase II Avelumab Avelumab and Radiation in Muscle-Invasive Bladder Cancer Recruiting
NCT03837821 Phase I Abemaciclib Window of Opportunity Trial of Abemaciclib for Bladder Cancer Recruiting
NCT03924856 Phase III Cisplatin + Gemcitabine + Pembrolizumab Cisplatin + Gemcitabine Perioperative Pembrolizumab (MK-3475) Plus Neoadjuvant Chemotherapy Versus Perioperative Placebo Plus Neoadjuvant Chemotherapy for Cisplatin-eligible Muscle-invasive Bladder Cancer (MIBC) (MK-3475-866/KEYNOTE-866) (KEYNOTE-866) Recruiting
NCT03924895 Phase III Pembrolizumab Perioperative Pembrolizumab (MK-3475) Plus Cystectomy Versus Cystectomy Alone in Cisplatin-ineligible Participants With Muscle-invasive Bladder Cancer (MK-3475-905/KEYNOTE-905) Recruiting