Disease Detail

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ID DOID:162
Name cancer
Definition A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis.
Source DiseaseOntology.org
Alt Ids
Path disease disease of cellular proliferation cancer

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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
RET mutant Sorafenib cancer sensitive detail...
JAK1 F958V Ruxolitinib cancer resistant detail...
JAK1 F958C Ruxolitinib cancer resistant detail...
JAK1 F958L Ruxolitinib cancer resistant detail...
JAK1 F958S Ruxolitinib cancer resistant detail...
JAK1 P960T Ruxolitinib cancer resistant detail...
JAK1 P960S Ruxolitinib cancer resistant detail...
JAK2 Y931C Ruxolitinib cancer resistant detail...
JAK2 V617F JAK2 Y931C Ruxolitinib cancer resistant detail...
JAK1 V658F JAK1 F958C Ruxolitinib cancer resistant detail...
JAK1 A723D Ruxolitinib cancer sensitive detail...
JAK1 D895H Ruxolitinib cancer sensitive detail...
JAK1 E897K Ruxolitinib cancer sensitive detail...
JAK1 F734L Ruxolitinib cancer sensitive detail...
JAK1 K1026E Ruxolitinib cancer sensitive detail...
JAK1 L783F Ruxolitinib cancer sensitive detail...
JAK1 L910Q Ruxolitinib cancer sensitive detail...
JAK1 P815S Ruxolitinib cancer sensitive detail...
JAK1 R724S Ruxolitinib cancer sensitive detail...
JAK1 S1043I Ruxolitinib cancer sensitive detail...
JAK1 S646F Ruxolitinib cancer sensitive detail...
JAK1 S703I Ruxolitinib cancer sensitive detail...
JAK1 T901R Ruxolitinib cancer sensitive detail...
JAK1 V658F Ruxolitinib cancer sensitive detail...
JAK1 V658I Ruxolitinib cancer sensitive detail...
JAK1 Y1035C Ruxolitinib cancer sensitive detail...
JAK1 Y652H Ruxolitinib cancer sensitive detail...
JAK1 V658L Ruxolitinib cancer sensitive detail...
HRAS wild-type FTI-277 cancer predicted - sensitive detail...
JAK2 R683G JAK2 E864K NVP-BSK805 cancer resistant detail...
JAK2 R683G JAK2 E864K NVP-BVB808 cancer resistant detail...
JAK2 R683G JAK2 G935R Ruxolitinib cancer resistant detail...
JAK2 R683G JAK2 G935R NVP-BSK805 cancer resistant detail...
JAK2 R683G JAK2 G935R NVP-BVB808 cancer resistant detail...
FLT3 I836del Tandutinib cancer sensitive detail...
FLT3 I836del Midostaurin cancer sensitive detail...
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT02484053 Phase I Rituximab Rapid Infusion Rituximab, Hematologic, Oncologic, and Rheumatologic Disorders Completed USA 0
NCT03543358 Phase II Rovalpituzumab Tesirine A Long-Term Study of Rovalpituzumab Tesirine Completed USA 0
NCT03768063 FDA approved Atezolizumab A Study in Patients Previously Enrolled in a Genentech and/or F. Hoffmann-La Roche Ltd Sponsored Atezolizumab Study (IMbrella B) Recruiting USA | ITA | FRA | ESP | DEU | CAN | BEL 25
NCT03844048 Phase III Venetoclax An Extension Study of Venetoclax for Subjects Who Have Completed a Prior Venetoclax Clinical Trial Enrolling by invitation USA | FRA | ESP | CAN | BEL | AUT 14
NCT03899155 FDA approved Nivolumab Pan Tumor Nivolumab Rollover Study Recruiting USA | ITA | FRA | ESP | DEU | CAN | BEL | AUT 27
NCT03912831 Phase I Cyclophosphamide + Fludarabine KITE-439 Safety and Efficacy of KITE-439 in HLA-A*02:01+ Adults With Relapsed/Refractory HPV16+ Cancers Terminated USA 0
NCT03926143 Phase II Anetumab ravtansine A Clinical Study of Anetumab Ravtansine in Adults With Solid Tumors Who Have Been Treated in Previous Bayer-sponsored Anetumab Ravtansine Studies Completed USA | ITA | FRA 1
NCT04464226 Phase III Darolutamide Study to Continue Treatment With Darolutamide in Patients Who Have Been Participating in Previous Darolutamide Studies Supported by Bayer Recruiting USA | ITA | FRA | ESP | DEU | CAN | BEL | AUT 31