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Therapy Name Rovalpituzumab Tesirine
Synonyms
Therapy Description

Rovalpituzumab Tesirine (Rova-T) is an antibody drug conjugate of pyrrolobenzodiazepine (PBD) cytotoxin D6.5 and human anti-delta-like 3 (DLL3) antibody, which targets and kills DLL-3 expressing tumor cells (PMID: 26311731).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Rovalpituzumab Tesirine Rova-T|SC16LD6.5 Rovalpituzumab Tesirine (Rova-T) is an antibody drug conjugate of pyrrolobenzodiazepine (PBD) cytotoxin D6.5 and human anti-delta-like 3 (DLL3) antibody, which targets and kills DLL-3 expressing tumor cells (PMID: 26311731).

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT02819999 Phase I Cisplatin + Etoposide + Rovalpituzumab Tesirine Rovalpituzumab Tesirine A Study of Rovalpituzumab Tesirine (SC16LD6.5) in the Frontline Treatment of Patients With Delta-Like Protein 3-Expressing Extensive Stage Small Cell Lung Cancer Terminated USA 0
NCT03061812 Phase III Rovalpituzumab Tesirine Topotecan Study Comparing Rovalpituzumab Tesirine Versus Topotecan in Subjects With Advanced or Metastatic Small Cell Lung Cancer With High Levels of Delta-like Protein 3 (DLL3) and Who Have First Disease Progression During or Following Front-line Platinum-based Chemotherapy (TAHOE) (TAHOE) Completed USA | NLD | ITA | GBR | FRA | ESP | DEU | CAN | BEL | AUS 23
NCT02709889 Phase Ib/II Rovalpituzumab Tesirine Rovalpituzumab Tesirine in Delta-Like Protein 3-Expressing Advanced Solid Tumors Terminated USA 0
NCT02674568 Phase II Rovalpituzumab Tesirine Study of Rovalpituzumab Tesirine (SC16LD6.5) for Third-line and Later Treatment of Subjects With Relapsed or Refractory Delta-Like Protein 3-Expressing Small Cell Lung Cancer (TRINITY) Completed 0
NCT03543358 Phase II Rovalpituzumab Tesirine A Long-Term Study of Rovalpituzumab Tesirine Completed USA 0
NCT02874664 Phase I Rovalpituzumab Tesirine A Study of Rovalpituzumab Tesirine to Study Cardiac Ventricular Repolarization in Subjects With Small Cell Lung Cancer Completed USA | CAN 0


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