Therapy Detail
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| Therapy Name | Cabozantinib + Pembrolizumab |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Cabozantinib | Cometriq | Cabometyx|Cabozantinib-s-malate|XL184 | AXL Inhibitor 29 FLT3 Inhibitor 62 KIT Inhibitor 56 MET Inhibitor 57 RET Inhibitor 50 ROS1 Inhibitor 20 VEGFR2 Inhibitor 36 | Cometriq (Cabometyx, cabozantinib) inhibits several receptor tyrosine kinases, including VEGFR2, FLT3, AXL, MET, RET, ROS1 fusions, and c-KIT (PMID: 27370605, PMID: 21926191). Cometriq (cabozantinib) is FDA approved for use in patients with medullary thyroid cancer, Cabometyx (cabozantinib) is FDA approved for use in patients with advanced renal cell carcinoma, hepatocellular carcinoma previously treated with sorafenib, adult and pediatric patients 12 years and older with locally advanced or metastatic differentiated thyroid cancer, and in combination with Opdivo (nivolumab) in patients with advanced renal cell carcinoma (FDA.gov). |
| Pembrolizumab | Keytruda | MK-3475 | Immune Checkpoint Inhibitor 155 PD-L1/PD-1 antibody 106 | Keytruda (pembrolizumab) is an antibody against PD-1 that activates T-cell mediated anti-tumor immune response (PMID: 25977344). Keytruda (pembrolizumab) is approved in melanoma, SCLC, HNSCC, classical Hodgkin Lymphoma, primary mediastinal large B-cell lymphoma, urothelial carcinoma, HCC, Merkel cell carcinoma, NMIBC, cutaneous squamous cell carcinoma, MSI-H or dMMR or TMB high advanced solid tumors, NSCLC and CD274 (PD-L1)-expressing NSCLC, gastric and GEJ adenocarcinoma, squamous esophageal carcinoma, cervical cancer, and triple-negative breast cancer, in combination with pemetrexed and platinum in non-squamous NSCLC with no EGFR or ALK mutations, with carboplatin and paclitaxel/nab-paclitaxel in squamous NSCLC, with axitinib or lenvatinib in RCC, with Lenvatinib in endometrial carcinoma that is not MSI-H or dMMR, in combination with platinum and fluoropyrimidine-based chemotherapy for patients with esophageal or gastroesophageal carcinoma, in combination with Herceptin (trastuzumab), fluoropyrimidine- and platinum-containing chemotherapy for first-line treatment of patients with HER2-positive gastric or gastroesophageal junction adenocarcinoma, and in combination with platinum-based chemotherapy, with or without bevacizumab, for patients with CD274 (PD-L1)-expressing (CPS>=1) cervical cancer (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05613413 | Phase II | Cabozantinib + Pembrolizumab | A Pilot Phase II Study of Maintenance Cabozantinib Plus Pembrolizumab for Patients With Metastatic Squamous Non-Small Cell Lung Cancer (sqNSCLC) (LUNG-IST-127) | Recruiting | USA | 0 |
| NCT03149822 | Phase Ib/II | Cabozantinib + Pembrolizumab | Study of Pembrolizumab and Cabozantinib in Patients With Metastatic Renal Cell Carcinoma | Active, not recruiting | USA | 0 |
| NCT05182164 | Phase II | Cabozantinib + Pembrolizumab | Combination of Pembrolizumab and Cabozantinib in Patients With Advanced Sarcomas (PEMBROCABOSARC) | Recruiting | FRA | 0 |
| NCT03468218 | Phase II | Cabozantinib + Pembrolizumab | Pembrolizumab & Cabozantinib in Patients With Head and Neck Squamous Cell Cancer Who Have Failed Platinum Based Therapy | Active, not recruiting | USA | 0 |
| NCT05052723 | Phase II | Cabozantinib + Pembrolizumab | Cabozantinib and Pembrolizumab in Metastatic Pancreas | Recruiting | USA | 0 |
| NCT04230954 | Phase II | Cabozantinib + Pembrolizumab | Cabozantinib Plus Pembrolizumab for Recurrent, Persistent and/or Metastatic Cervical Cancer | Terminated | USA | 0 |
| NCT04164979 | Phase II | Cabozantinib + Pembrolizumab | Ph II Study of Cabozantinib With Pembrolizumab in Metastatic Gastric and Gastroesophageal Adenocarcinoma | Recruiting | USA | 0 |
| NCT04442581 | Phase II | Cabozantinib + Pembrolizumab | Cabozantinib and Pembrolizumab for the First-Line Treatment of Advanced Liver Cancer | Terminated | USA | 0 |
| NCT03957551 | Phase Ib/II | Cabozantinib + Pembrolizumab | Cabozantinib and Pembrolizumab for Advanced Metastatic Melanoma | Recruiting | USA | 0 |
| NCT03534804 | Phase II | Cabozantinib + Pembrolizumab | Cabozantinib Plus Pembrolizumab as First-Line Therapy for Cisplatin-Ineligible Advanced Urothelial Carcinoma (PemCab) | Recruiting | USA | 0 |
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