Drug Detail

Drug Name Cabozantinib
Trade Name Cometriq
Synonyms Cabometyx|Cabozantinib-s-malate|XL184
Drug Descriptions

Cometriq (Cabometyx, cabozantinib) inhibits several receptor tyrosine kinases, including VEGFR2, FLT3, AXL, MET, RET, ROS1 fusions, and c-KIT (PMID: 27370605, PMID: 21926191). Cometriq (cabozantinib) is FDA approved for medullary thyroid cancer and Cabometyx (cabozantinib) is FDA approved for advanced renal cell carcinoma and in sorafenib previously treated hepatocellular carcinoma (FDA.gov).

DrugClasses AXL Inhibitor 24 FLT3 Inhibitor 50 KIT Inhibitor 50 MET Inhibitor 51 RET Inhibitor 36 ROS1 Inhibitor 14 VEGFR2 Inhibitor 34

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abiraterone + Cabozantinib Abiraterone Cabozantinib 0 0
Afatinib + Cabozantinib Afatinib Cabozantinib 0 0
Atezolizumab + Cabozantinib Atezolizumab Cabozantinib 0 3
Avelumab + Cabozantinib Avelumab Cabozantinib 0 1
Cabozantinib Cabozantinib 49 43
Cabozantinib + Carfilzomib + Dexamethasone Cabozantinib Carfilzomib Dexamethasone 0 1
Cabozantinib + CB-839 CB-839 Cabozantinib 0 2
Cabozantinib + Cetuximab Cabozantinib Cetuximab 0 1
Cabozantinib + CT-707 CT-707 Cabozantinib 1 0
Cabozantinib + Docetaxel Cabozantinib Docetaxel 0 1
Cabozantinib + Durvalumab Cabozantinib Durvalumab 0 1
Cabozantinib + Erlotinib Cabozantinib Erlotinib 3 2
Cabozantinib + Fulvestrant Cabozantinib Fulvestrant 0 1
Cabozantinib + Gefitinib Cabozantinib Gefitinib 0 0
Cabozantinib + Gemcitabine Cabozantinib Gemcitabine 0 1
Cabozantinib + Ipilimumab + Nivolumab Cabozantinib Ipilimumab Nivolumab 0 4
Cabozantinib + Isotretinoin Cabozantinib Isotretinoin 0 1
Cabozantinib + Navitoclax Cabozantinib Navitoclax 1 0
Cabozantinib + Nivolumab Cabozantinib Nivolumab 0 10
Cabozantinib + Osimertinib Cabozantinib Osimertinib 2 0
Cabozantinib + Panitumumab Cabozantinib Panitumumab 0 1
Cabozantinib + Pembrolizumab Cabozantinib Pembrolizumab 0 4
Cabozantinib + PT 2977 Cabozantinib PT 2977 0 1
Cabozantinib + Sunitinib Cabozantinib Sunitinib 0 2
Cabozantinib + unspecified CTLA4 antibody + unspecified PD-1 antibody Cabozantinib unspecified CTLA4 antibody unspecified PD-1 antibody 1 0
Cabozantinib + Vandetanib Cabozantinib Vandetanib 0 1
Cabozantinib + Vemurafenib Cabozantinib Vemurafenib 0 1


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