Drug Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Cabozantinib
Trade Name Cometriq
Synonyms Cabometyx|Cabozantinib-s-malate|XL184
Drug Descriptions

Cometriq (Cabometyx, cabozantinib) inhibits several receptor tyrosine kinases, including VEGFR2, FLT3, AXL, MET, RET, ROS1 fusions, and c-KIT (PMID: 27370605, PMID: 21926191). Cometriq (cabozantinib) is FDA approved for medullary thyroid cancer and Cabometyx (cabozantinib) is FDA approved for advanced renal cell carcinoma and in sorafenib previously treated hepatocellular carcinoma (FDA.gov).
DrugClasses AXL Inhibitor 27 FLT3 Inhibitor 55 KIT Inhibitor 51 MET Inhibitor 51 RET Inhibitor 39 ROS1 Inhibitor 14 VEGFR2 Inhibitor 35

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Abiraterone + Cabozantinib Abiraterone Cabozantinib 0 0
Abiraterone + Cabozantinib + Nivolumab + Prednisone Abiraterone Cabozantinib Nivolumab Prednisone 0 1
Afatinib + Cabozantinib Afatinib Cabozantinib 0 0
Atezolizumab + Cabozantinib Atezolizumab Cabozantinib 1 7
AVB-S6-500 + Cabozantinib AVB-S6-500 Cabozantinib 0 1
Avelumab + Cabozantinib Avelumab Cabozantinib 0 1
Cabozantinib Cabozantinib 41 54
Cabozantinib + Carfilzomib + Dexamethasone Cabozantinib Carfilzomib Dexamethasone 0 1
Cabozantinib + Cetuximab Cabozantinib Cetuximab 0 1
Cabozantinib + Chloroquine Cabozantinib Chloroquine 1 0
Cabozantinib + CT-707 CT-707 Cabozantinib 1 0
Cabozantinib + Docetaxel Cabozantinib Docetaxel 0 1
Cabozantinib + Durvalumab Cabozantinib Durvalumab 0 1
Cabozantinib + Erlotinib Cabozantinib Erlotinib 1 2
Cabozantinib + Fulvestrant Cabozantinib Fulvestrant 0 1
Cabozantinib + Gefitinib Cabozantinib Gefitinib 0 0
Cabozantinib + Gemcitabine Cabozantinib Gemcitabine 0 1
Cabozantinib + Ipilimumab + Nivolumab Cabozantinib Ipilimumab Nivolumab 0 12
Cabozantinib + Isotretinoin Cabozantinib Isotretinoin 0 1
Cabozantinib + Navitoclax Cabozantinib Navitoclax 1 0
Cabozantinib + Nivolumab Cabozantinib Nivolumab 0 16
Cabozantinib + Osimertinib Cabozantinib Osimertinib 0 0
Cabozantinib + Panitumumab Cabozantinib Panitumumab 0 1
Cabozantinib + Pembrolizumab Cabozantinib Pembrolizumab 0 7
Cabozantinib + Pemetrexed Disodium Cabozantinib Pemetrexed Disodium 0 1
Cabozantinib + PT 2977 Cabozantinib PT 2977 0 1
Cabozantinib + Radium Ra 223 dichloride Cabozantinib Radium Ra 223 dichloride 0 1
Cabozantinib + SBI-0206965 Cabozantinib SBI-0206965 1 0
Cabozantinib + Sunitinib Cabozantinib Sunitinib 0 2
Cabozantinib + Telaglenastat Cabozantinib Telaglenastat 0 2
Cabozantinib + Temozolomide Cabozantinib Temozolomide 0 1
Cabozantinib + Trametinib Cabozantinib Trametinib 0 0
Cabozantinib + unspecified CTLA4 antibody + unspecified PD-1 antibody Cabozantinib unspecified CTLA4 antibody unspecified PD-1 antibody 1 0
Cabozantinib + Vandetanib Cabozantinib Vandetanib 0 1
Cabozantinib + Vemurafenib Cabozantinib Vemurafenib 0 1
Cabozantinib + XOMA 052 Cabozantinib XOMA 052 0 1


Additional content available in CKB BOOST