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Drug Name Cabozantinib
Trade Name Cometriq
Synonyms Cabometyx|Cabozantinib-s-malate|XL184
Drug Descriptions

Cometriq (Cabometyx, cabozantinib) inhibits several receptor tyrosine kinases, including VEGFR2, FLT3, AXL, MET, RET, ROS1 fusions, and c-KIT (PMID: 27370605, PMID: 21926191). Cometriq (cabozantinib) is FDA approved for medullary thyroid cancer and Cabometyx (cabozantinib) is FDA approved for advanced renal cell carcinoma and in sorafenib previously treated hepatocellular carcinoma (FDA.gov).

DrugClasses AXL Inhibitor 27 FLT3 Inhibitor 55 KIT Inhibitor 51 MET Inhibitor 51 RET Inhibitor 39 ROS1 Inhibitor 14 VEGFR2 Inhibitor 35

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abiraterone + Cabozantinib Abiraterone Cabozantinib 0 0
Abiraterone + Cabozantinib + Nivolumab + Prednisone Abiraterone Cabozantinib Nivolumab Prednisone 0 1
Afatinib + Cabozantinib Afatinib Cabozantinib 0 0
Atezolizumab + Cabozantinib Atezolizumab Cabozantinib 1 7
AVB-S6-500 + Cabozantinib AVB-S6-500 Cabozantinib 0 1
Avelumab + Cabozantinib Avelumab Cabozantinib 0 1
Cabozantinib Cabozantinib 41 54
Cabozantinib + Carfilzomib + Dexamethasone Cabozantinib Carfilzomib Dexamethasone 0 1
Cabozantinib + Cetuximab Cabozantinib Cetuximab 0 1
Cabozantinib + Chloroquine Cabozantinib Chloroquine 1 0
Cabozantinib + CT-707 CT-707 Cabozantinib 1 0
Cabozantinib + Docetaxel Cabozantinib Docetaxel 0 1
Cabozantinib + Durvalumab Cabozantinib Durvalumab 0 1
Cabozantinib + Erlotinib Cabozantinib Erlotinib 1 2
Cabozantinib + Fulvestrant Cabozantinib Fulvestrant 0 1
Cabozantinib + Gefitinib Cabozantinib Gefitinib 0 0
Cabozantinib + Gemcitabine Cabozantinib Gemcitabine 0 1
Cabozantinib + Ipilimumab + Nivolumab Cabozantinib Ipilimumab Nivolumab 0 12
Cabozantinib + Isotretinoin Cabozantinib Isotretinoin 0 1
Cabozantinib + Navitoclax Cabozantinib Navitoclax 1 0
Cabozantinib + Nivolumab Cabozantinib Nivolumab 0 16
Cabozantinib + Osimertinib Cabozantinib Osimertinib 0 0
Cabozantinib + Panitumumab Cabozantinib Panitumumab 0 1
Cabozantinib + Pembrolizumab Cabozantinib Pembrolizumab 0 7
Cabozantinib + Pemetrexed Disodium Cabozantinib Pemetrexed Disodium 0 1
Cabozantinib + PT 2977 Cabozantinib PT 2977 0 1
Cabozantinib + Radium Ra 223 dichloride Cabozantinib Radium Ra 223 dichloride 0 1
Cabozantinib + SBI-0206965 Cabozantinib SBI-0206965 1 0
Cabozantinib + Sunitinib Cabozantinib Sunitinib 0 2
Cabozantinib + Telaglenastat Cabozantinib Telaglenastat 0 2
Cabozantinib + Temozolomide Cabozantinib Temozolomide 0 1
Cabozantinib + Trametinib Cabozantinib Trametinib 0 0
Cabozantinib + unspecified CTLA4 antibody + unspecified PD-1 antibody Cabozantinib unspecified CTLA4 antibody unspecified PD-1 antibody 1 0
Cabozantinib + Vandetanib Cabozantinib Vandetanib 0 1
Cabozantinib + Vemurafenib Cabozantinib Vemurafenib 0 1
Cabozantinib + XOMA 052 Cabozantinib XOMA 052 0 1


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