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Drug Name Methotrexate
Trade Name Abitrexate
Synonyms Amethopterin
Drug Descriptions

Methotrexate is an antimetabolite, which inhibits DHFR resulting in decreased immune function and antineoplastic activity and is FDA approved for psoriasis, RA, and several cancers including choriocarcinoma, AML, lung, head and neck and epidermoid (FDA.gov).

DrugClasses Chemotherapy - Antimetabolite 11

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Aldoxorubicin + Cisplatin + Filgrastim + Methotrexate + Vinblastine Aldoxorubicin Cisplatin Filgrastim Methotrexate Vinblastine 0 1
Aldoxorubicin + Cisplatin + Methotrexate + Vincristine Sulfate Aldoxorubicin Cisplatin Methotrexate Vincristine Sulfate 0 1
Arsenic trioxide + Cytarabine + Methotrexate + Tretinoin Arsenic trioxide Cytarabine Methotrexate Tretinoin 1 0
Blinatumomab + Cytarabine + Dexamethasone + Methotrexate + Ponatinib Blinatumomab Cytarabine Dexamethasone Methotrexate Ponatinib 0 0
Blinatumomab + Cytarabine + Methotrexate + Ponatinib Blinatumomab Cytarabine Methotrexate Ponatinib 0 1
Blinatumomab + Dasatinib + Methotrexate Blinatumomab Dasatinib Methotrexate 0 1
Blinatumomab + Dexamethasone + Leucovorin + Methotrexate Blinatumomab Dexamethasone Leucovorin Methotrexate 0 1
Blinatumomab + Dexamethasone + Methotrexate Blinatumomab Dexamethasone Methotrexate 0 1
Blinatumomab + Leucovorin + Methotrexate Blinatumomab Leucovorin Methotrexate 0 1
Blinatumomab + Mercaptopurine + Methotrexate + Prednisone + Vincristine Sulfate Blinatumomab Mercaptopurine Methotrexate Prednisone Vincristine Sulfate 0 1
Blinatumomab + Methotrexate Blinatumomab Methotrexate 0 1
Busulfan + Fludarabine + GVAX + Methotrexate + Tacrolimus Busulfan Fludarabine GVAX Methotrexate Tacrolimus 0 1
Busulfan + Fludarabine + Methotrexate + Tacrolimus Busulfan Fludarabine Methotrexate Tacrolimus 0 1
Calaspargase pegol-mknl + Dexamethasone + Etoposide + Ifosfamide + Methotrexate Calaspargase pegol-mknl Dexamethasone Etoposide Ifosfamide Methotrexate 0 1
Carboplatin + Cyclophosphamide + Methotrexate + Vincristine Sulfate Carboplatin Cyclophosphamide Methotrexate Vincristine Sulfate 0 1
Carboplatin + Methotrexate + Rituximab Carboplatin Methotrexate Rituximab 0 1
Cetuximab + Docetaxel + Methotrexate Cetuximab Docetaxel Methotrexate 0 0
Cetuximab + Methotrexate Cetuximab Methotrexate 0 0
Cisplatin + Cyclophosphamide + Methotrexate + Vincristine Sulfate Cisplatin Cyclophosphamide Methotrexate Vincristine Sulfate 0 2
Cisplatin + Doxorubicin + Durvalumab + Methotrexate + Vinblastine Cisplatin Doxorubicin Durvalumab Methotrexate Vinblastine 0 1
Cisplatin + Doxorubicin + Methotrexate + Pegfilgrastim + Pembrolizumab + Vinblastine Cisplatin Doxorubicin Methotrexate Pegfilgrastim Pembrolizumab Vinblastine 0 1
Cyclophosphamide + Cytarabine + Dexamethasone + Doxorubicin + Imatinib + Methotrexate + Vincristine Sulfate Cyclophosphamide Cytarabine Dexamethasone Doxorubicin Imatinib Methotrexate Vincristine Sulfate 0 0
Cyclophosphamide + Cytarabine + Dexamethasone + Doxorubicin + Leucovorin + Methotrexate + Pegaspargase + Thioguanine + Vincristine Sulfate Cyclophosphamide Cytarabine Dexamethasone Doxorubicin Leucovorin Methotrexate Pegaspargase Thioguanine Vincristine Sulfate 0 1
Cyclophosphamide + Cytarabine + Dexamethasone + Doxorubicin + Leucovorin + Methotrexate + Pegaspargase + Vincristine Sulfate Cyclophosphamide Cytarabine Dexamethasone Doxorubicin Leucovorin Methotrexate Pegaspargase Vincristine Sulfate 0 0
Cyclophosphamide + Cytarabine + Dexamethasone + Doxorubicin + Methotrexate + Ofatumumab + Vincristine Sulfate Cyclophosphamide Cytarabine Dexamethasone Doxorubicin Methotrexate Ofatumumab Vincristine Sulfate 0 1
Cyclophosphamide + Cytarabine + Dexamethasone + Doxorubicin + Methotrexate + Pegaspargase + Thioguanine + Vincristine Sulfate Cyclophosphamide Cytarabine Dexamethasone Doxorubicin Methotrexate Pegaspargase Thioguanine Vincristine Sulfate 0 1
Cyclophosphamide + Cytarabine + Dexamethasone + Doxorubicin + Methotrexate + Rituximab + Venetoclax + Vincristine Sulfate Cyclophosphamide Cytarabine Dexamethasone Doxorubicin Methotrexate Rituximab Venetoclax Vincristine Sulfate 0 1
Cyclophosphamide + Cytarabine + Dexamethasone + Doxorubicin + Methotrexate + Rituximab + Vincristine Sulfate Cyclophosphamide Cytarabine Dexamethasone Doxorubicin Methotrexate Rituximab Vincristine Sulfate 0 1
Cyclophosphamide + Cytarabine + Dexamethasone + Doxorubicin + Methotrexate + Vincristine Sulfate Cyclophosphamide Cytarabine Dexamethasone Doxorubicin Methotrexate Vincristine Sulfate 0 1
Cyclophosphamide + Cytarabine + Dexamethasone + Methotrexate + Rituximab + Venetoclax + Vincristine Sulfate Cyclophosphamide Cytarabine Dexamethasone Methotrexate Rituximab Venetoclax Vincristine Sulfate 0 1
Cyclophosphamide + Cytarabine + Doxorubicin + Etoposide + Filgrastim + Ifosfamide + Leucovorin + Mesna + Methotrexate + Rituximab + Vincristine Sulfate Cyclophosphamide Cytarabine Doxorubicin Etoposide Filgrastim Ifosfamide Leucovorin Mesna Methotrexate Rituximab Vincristine Sulfate 0 1
Cyclophosphamide + Cytarabine + Hydrocortisone + Mercaptopurine + Methotrexate Cyclophosphamide Cytarabine Hydrocortisone Mercaptopurine Methotrexate 0 1
Cyclophosphamide + Cytarabine + Inotuzumab ozogamicin + Methotrexate + Vincristine Sulfate Cyclophosphamide Cytarabine Inotuzumab ozogamicin Methotrexate Vincristine Sulfate 0 1
Cyclophosphamide + Cytarabine + Leucovorin + Mercaptopurine + Methotrexate + Pegaspargase + Vincristine Sulfate Cyclophosphamide Cytarabine Leucovorin Mercaptopurine Methotrexate Pegaspargase Vincristine Sulfate 0 1
Cyclophosphamide + Cytarabine + Mercaptopurine + Methotrexate + Pegaspargase + Vincristine Sulfate Cyclophosphamide Cytarabine Mercaptopurine Methotrexate Pegaspargase Vincristine Sulfate 0 2
Cyclophosphamide + Cytarabine + Methotrexate + Pegaspargase + Thioguanine + Vincristine Sulfate Cyclophosphamide Cytarabine Methotrexate Pegaspargase Thioguanine Vincristine Sulfate 0 1
Cyclophosphamide + Dexamethasone + Doxorubicin + Methotrexate + Rituximab + Venetoclax + Vincristine Sulfate Cyclophosphamide Dexamethasone Doxorubicin Methotrexate Rituximab Venetoclax Vincristine Sulfate 0 1
Cyclophosphamide + Dexamethasone + Methotrexate + Rituximab + Venetoclax + Vincristine Sulfate Cyclophosphamide Dexamethasone Methotrexate Rituximab Venetoclax Vincristine Sulfate 0 1
Cyclophosphamide + Methotrexate + Pegaspargase + Vincristine Sulfate Cyclophosphamide Methotrexate Pegaspargase Vincristine Sulfate 0 2
Cyclophosphamide + Methotrexate + Vandetanib Cyclophosphamide Methotrexate Vandetanib 1 0
Cyclophosphamide + Methotrexate + Vincristine Sulfate Cyclophosphamide Methotrexate Vincristine Sulfate 0 1
Cytarabine + Daunorubicin + Dexamethasone + Hydrocortisone + Methotrexate + Pegaspargase + Prednisolone + Vincristine Sulfate Cytarabine Daunorubicin Dexamethasone Hydrocortisone Methotrexate Pegaspargase Prednisolone Vincristine Sulfate 0 1
Cytarabine + Daunorubicin + Dexamethasone + Methotrexate + Pegaspargase + Vincristine Sulfate Cytarabine Daunorubicin Dexamethasone Methotrexate Pegaspargase Vincristine Sulfate 0 1
Cytarabine + Daunorubicin + Fludarabine + Hydrocortisone + Methotrexate + Quizartinib Cytarabine Daunorubicin Fludarabine Hydrocortisone Methotrexate Quizartinib 0 1
Cytarabine + Daunorubicin + Fludarabine + Methotrexate + Prednisolone + Quizartinib Cytarabine Daunorubicin Fludarabine Methotrexate Prednisolone Quizartinib 0 1
Cytarabine + Daunorubicin + Inotuzumab ozogamicin + Methotrexate + Pegaspargase + Prednisone + Vincristine Sulfate Cytarabine Daunorubicin Inotuzumab ozogamicin Methotrexate Pegaspargase Prednisone Vincristine Sulfate 0 0
Cytarabine + Daunorubicin + Inotuzumab ozogamicin + Methotrexate + Prednisone + Vincristine Sulfate Cytarabine Daunorubicin Inotuzumab ozogamicin Methotrexate Prednisone Vincristine Sulfate 0 0
Cytarabine + Daunorubicin + Methotrexate + Pegaspargase + Prednisolone + Vincristine Sulfate Cytarabine Daunorubicin Methotrexate Pegaspargase Prednisolone Vincristine Sulfate 0 1
Cytarabine + Dexamethasone + Methotrexate Cytarabine Dexamethasone Methotrexate 0 3
Cytarabine + Dexamethasone + Methotrexate + Pegaspargase + Vincristine Sulfate Cytarabine Dexamethasone Methotrexate Pegaspargase Vincristine Sulfate 0 1
Cytarabine + Dexamethasone + Methotrexate + Ponatinib + Rituximab + Venetoclax Cytarabine Dexamethasone Methotrexate Ponatinib Rituximab Venetoclax 0 0
Cytarabine + Dexamethasone + Methotrexate + Vincristine Sulfate Cytarabine Dexamethasone Methotrexate Vincristine Sulfate 0 0
Cytarabine + Doxorubicin + Methotrexate + Vincristine Sulfate Cytarabine Doxorubicin Methotrexate Vincristine Sulfate 0 1
Cytarabine + Etoposide + Methotrexate Cytarabine Etoposide Methotrexate 0 1
Cytarabine + Fludarabine + Methotrexate + Prednisolone Cytarabine Fludarabine Methotrexate Prednisolone 0 1
Cytarabine + Fludarabine + Methotrexate + Prednisolone + Quizartinib Cytarabine Fludarabine Methotrexate Prednisolone Quizartinib 0 1
Cytarabine + Fludarabine + Methotrexate + Prednisone + Selinexor Cytarabine Fludarabine Methotrexate Prednisone Selinexor 0 1
Cytarabine + Hydrocortisone + Idasanutlin + Methotrexate + Venetoclax Cytarabine Hydrocortisone Idasanutlin Methotrexate Venetoclax 0 0
Cytarabine + Hydrocortisone + Mercaptopurine + Methotrexate Cytarabine Hydrocortisone Mercaptopurine Methotrexate 0 1
Cytarabine + Hydrocortisone + Methotrexate Cytarabine Hydrocortisone Methotrexate 0 4
Cytarabine + Imatinib + Methotrexate Cytarabine Imatinib Methotrexate 0 1
Cytarabine + Inotuzumab ozogamicin + Methotrexate Cytarabine Inotuzumab ozogamicin Methotrexate 0 1
Cytarabine + Leucovorin + Methotrexate Cytarabine Leucovorin Methotrexate 0 3
Cytarabine + Leucovorin + Methotrexate + Pegaspargase + Vincristine Sulfate Cytarabine Leucovorin Methotrexate Pegaspargase Vincristine Sulfate 0 1
Cytarabine + Methotrexate Cytarabine Methotrexate 0 2
Cytarabine + Methotrexate + Methylprednisolone + Rituximab + Venetoclax Cytarabine Methotrexate Methylprednisolone Rituximab Venetoclax 0 1
Cytarabine + Methotrexate + Nelarabine + Pegaspargase + Venetoclax Cytarabine Methotrexate Nelarabine Pegaspargase Venetoclax 0 1
Cytarabine + Methotrexate + Ponatinib Cytarabine Methotrexate Ponatinib 0 2
Cytarabine + Methotrexate + Prednisone Cytarabine Methotrexate Prednisone 0 1
Cytarabine + Methotrexate + Rituximab Cytarabine Methotrexate Rituximab 0 1
Cytarabine + Methotrexate + Rituximab + Venetoclax Cytarabine Methotrexate Rituximab Venetoclax 0 2
Cytarabine + Methotrexate + Venetoclax Cytarabine Methotrexate Venetoclax 0 1
Dasatinib + Dexamethasone + Hydrocortisone + Methotrexate Dasatinib Dexamethasone Hydrocortisone Methotrexate 0 0
Dasatinib + Dexamethasone + Methotrexate Dasatinib Dexamethasone Methotrexate 0 1
Daunorubicin + Dexamethasone + Methotrexate + Pegaspargase + Vincristine Sulfate Daunorubicin Dexamethasone Methotrexate Pegaspargase Vincristine Sulfate 0 1
Dexamethasone + Doxorubicin + Methotrexate + Pegaspargase + Vincristine Sulfate Dexamethasone Doxorubicin Methotrexate Pegaspargase Vincristine Sulfate 0 2
Dexamethasone + Leucovorin + Mercaptopurine + Methotrexate + Vincristine Sulfate Dexamethasone Leucovorin Mercaptopurine Methotrexate Vincristine Sulfate 0 1
Dexamethasone + Leucovorin + Methotrexate + Vincristine Sulfate Dexamethasone Leucovorin Methotrexate Vincristine Sulfate 0 0
Dexamethasone + Mercaptopurine + Methotrexate + Vincristine Sulfate Dexamethasone Mercaptopurine Methotrexate Vincristine Sulfate 0 1
Dexamethasone + Mercaptopurine + Methotrexate + Vincristine sulfate liposome Dexamethasone Mercaptopurine Methotrexate Vincristine sulfate liposome 0 1
Dexamethasone + Methotrexate + Mitoxantrone + Pegaspargase + Vincristine sulfate liposome Dexamethasone Methotrexate Mitoxantrone Pegaspargase Vincristine sulfate liposome 0 1
Dexamethasone + Methotrexate + Pegaspargase + Vincristine sulfate liposome Dexamethasone Methotrexate Pegaspargase Vincristine sulfate liposome 0 1
Filgrastim + Methotrexate Filgrastim Methotrexate 0 1
Filgrastim + Methotrexate + Rituximab Filgrastim Methotrexate Rituximab 0 1
Glucarpidase + Leucovorin + Methotrexate + Rituximab Glucarpidase Leucovorin Methotrexate Rituximab 0 1
Idasanutlin + Methotrexate + Venetoclax Idasanutlin Methotrexate Venetoclax 0 0
Inotuzumab ozogamicin + Methotrexate Inotuzumab ozogamicin Methotrexate 0 1
Leucovorin + Mercaptopurine + Methotrexate + Vincristine Sulfate Leucovorin Mercaptopurine Methotrexate Vincristine Sulfate 0 2
Leucovorin + Methotrexate + Vincristine Sulfate Leucovorin Methotrexate Vincristine Sulfate 0 1
Mercaptopurine + Methotrexate Mercaptopurine Methotrexate 0 1
Mercaptopurine + Methotrexate + Prednisolone + Vincristine Sulfate Mercaptopurine Methotrexate Prednisolone Vincristine Sulfate 0 2
Mercaptopurine + Methotrexate + Prednisone + tagraxofusp-erzs + Venetoclax + Vincristine Sulfate Mercaptopurine Methotrexate Prednisone Venetoclax Vincristine Sulfate tagraxofusp-erzs 0 1
Mercaptopurine + Methotrexate + Prednisone + Venetoclax + Vincristine Sulfate Mercaptopurine Methotrexate Prednisone Venetoclax Vincristine Sulfate 0 1
Mercaptopurine + Methotrexate + Prednisone + Vincristine Sulfate Mercaptopurine Methotrexate Prednisone Vincristine Sulfate 0 6
Mercaptopurine + Methotrexate + Vincristine Sulfate Mercaptopurine Methotrexate Vincristine Sulfate 0 2
Methotrexate Methotrexate 0 40
Methotrexate + Pegaspargase Methotrexate Pegaspargase 0 1
Methotrexate + Pegaspargase + Venetoclax Methotrexate Pegaspargase Venetoclax 0 1
Methotrexate + Pegaspargase + Vincristine Sulfate Methotrexate Pegaspargase Vincristine Sulfate 0 2
Methotrexate + Regorafenib Methotrexate Regorafenib 0 1
Methotrexate + Ribociclib Methotrexate Ribociclib 2 0
Methotrexate + Sirolimus Methotrexate Sirolimus 0 1
Methotrexate + Sirolimus + Tacrolimus Methotrexate Sirolimus Tacrolimus 0 3
Methotrexate + Tacrolimus Methotrexate Tacrolimus 0 2
Methotrexate + UNC2025 Methotrexate UNC2025 0 0
Methotrexate + Vincristine Sulfate Methotrexate Vincristine Sulfate 0 1


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