Drug Detail

Drug Name Methotrexate
Trade Name Abitrexate
Synonyms Amethopterin
Drug Descriptions

Methotrexate is an antimetabolite, which inhibits DHFR resulting in decreased immune function and antineoplastic activity (NCI Drug Dictionary). Methotrexate is FDA approved for psoriasis, RA, and several cancers including choriocarcinoma, AML, lung, head and neck and epidermoid (FDA.gov).

DrugClasses Chemotherapy - Antimetabolite 10

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Aldoxorubicin + Cisplatin + Filgrastim + Methotrexate + Vinblastine Aldoxorubicin Cisplatin Filgrastim Methotrexate Vinblastine 0 1
Aldoxorubicin + Cisplatin + Methotrexate + Vincristine Aldoxorubicin Cisplatin Methotrexate Vincristine 0 1
Arsenic trioxide + Cytarabine + Methotrexate + Tretinoin Arsenic trioxide Cytarabine Methotrexate Tretinoin 1 0
Blinatumomab + Cytarabine + Dexamethasone + Methotrexate + Ponatinib Blinatumomab Cytarabine Dexamethasone Methotrexate Ponatinib 0 1
Blinatumomab + Dexamethasone + Leucovorin + Methotrexate Blinatumomab Dexamethasone Leucovorin Methotrexate 0 1
Blinatumomab + Dexamethasone + Methotrexate Blinatumomab Dexamethasone Methotrexate 0 1
Blinatumomab + Leucovorin + Methotrexate Blinatumomab Leucovorin Methotrexate 0 1
Blinatumomab + Methotrexate Blinatumomab Methotrexate 0 1
Carboplatin + Cyclophosphamide + Methotrexate + Vincristine Carboplatin Cyclophosphamide Methotrexate Vincristine 0 1
Carboplatin + Methotrexate + Rituximab Carboplatin Methotrexate Rituximab 0 1
Cetuximab + Docetaxel + Methotrexate Cetuximab Docetaxel Methotrexate 0 0
Cetuximab + Methotrexate Cetuximab Methotrexate 0 0
Cisplatin + Cyclophosphamide + Methotrexate + Vincristine Cisplatin Cyclophosphamide Methotrexate Vincristine 0 2
Cisplatin + Doxorubicin + Durvalumab + Methotrexate + Vinblastine Cisplatin Doxorubicin Durvalumab Methotrexate Vinblastine 0 1
Cyclophosphamide + Cytarabine + Dexamethasone + Doxorubicin + Leucovorin + Methotrexate + Pegaspargase + Thioguanine + Vincristine Cyclophosphamide Cytarabine Dexamethasone Doxorubicin Leucovorin Methotrexate Pegaspargase Thioguanine Vincristine 0 1
Cyclophosphamide + Cytarabine + Dexamethasone + Doxorubicin + Leucovorin + Methotrexate + Pegaspargase + Vincristine Cyclophosphamide Cytarabine Dexamethasone Doxorubicin Leucovorin Methotrexate Pegaspargase Vincristine 0 0
Cyclophosphamide + Cytarabine + Dexamethasone + Doxorubicin + Methotrexate + Pegaspargase + Thioguanine + Vincristine Cyclophosphamide Cytarabine Dexamethasone Doxorubicin Methotrexate Pegaspargase Thioguanine Vincristine 0 1
Cyclophosphamide + Cytarabine + Doxorubicin + Etoposide + Filgrastim + Ifosfamide + Leucovorin + Mesna + Methotrexate + Rituximab + Vincristine Cyclophosphamide Cytarabine Doxorubicin Etoposide Filgrastim Ifosfamide Leucovorin Mesna Methotrexate Rituximab Vincristine 0 1
Cyclophosphamide + Cytarabine + inotuzumab ozogamicin + Methotrexate + Vincristine Cyclophosphamide Cytarabine Methotrexate Vincristine inotuzumab ozogamicin 0 1
Cyclophosphamide + Cytarabine + Leucovorin + Mercaptopurine + Methotrexate + Pegaspargase + Vincristine Cyclophosphamide Cytarabine Leucovorin Mercaptopurine Methotrexate Pegaspargase Vincristine 0 1
Cyclophosphamide + Cytarabine + Mercaptopurine + Methotrexate + Pegaspargase + Vincristine Cyclophosphamide Cytarabine Mercaptopurine Methotrexate Pegaspargase Vincristine 0 1
Cyclophosphamide + Methotrexate + Pegaspargase + Vincristine Cyclophosphamide Methotrexate Pegaspargase Vincristine 0 2
Cyclophosphamide + Methotrexate + Vandetanib Cyclophosphamide Methotrexate Vandetanib 1 0
Cyclophosphamide + Methotrexate + Vincristine Cyclophosphamide Methotrexate Vincristine 0 1
Cytarabine + Daunorubicin + inotuzumab ozogamicin + Methotrexate + Pegaspargase + Prednisone + Vincristine Cytarabine Daunorubicin Methotrexate Pegaspargase Prednisone Vincristine inotuzumab ozogamicin 0 0
Cytarabine + Daunorubicin + inotuzumab ozogamicin + Methotrexate + Prednisone + Vincristine Cytarabine Daunorubicin Methotrexate Prednisone Vincristine inotuzumab ozogamicin 0 0
Cytarabine + Dexamethasone + Methotrexate Cytarabine Dexamethasone Methotrexate 0 3
Cytarabine + Dexamethasone + Methotrexate + Pegaspargase + Vincristine Cytarabine Dexamethasone Methotrexate Pegaspargase Vincristine 0 1
Cytarabine + Dexamethasone + Methotrexate + Ponatinib + Rituximab + Venetoclax Cytarabine Dexamethasone Methotrexate Ponatinib Rituximab Venetoclax 0 1
Cytarabine + Dexamethasone + Methotrexate + Vincristine Cytarabine Dexamethasone Methotrexate Vincristine 0 0
Cytarabine + Doxorubicin + Methotrexate + Vincristine Cytarabine Doxorubicin Methotrexate Vincristine 0 1
Cytarabine + Etoposide + Methotrexate Cytarabine Etoposide Methotrexate 0 1
Cytarabine + Fludarabine + Methotrexate + Prednisone + Selinexor Cytarabine Fludarabine Methotrexate Prednisone Selinexor 0 1
Cytarabine + Hydrocortisone + Methotrexate Cytarabine Hydrocortisone Methotrexate 0 3
Cytarabine + Imatinib + Methotrexate Cytarabine Imatinib Methotrexate 0 1
Cytarabine + inotuzumab ozogamicin + Methotrexate Cytarabine Methotrexate inotuzumab ozogamicin 0 1
Cytarabine + Leucovorin + Methotrexate Cytarabine Leucovorin Methotrexate 0 2
Cytarabine + Leucovorin + Methotrexate + Pegaspargase + Vincristine Cytarabine Leucovorin Methotrexate Pegaspargase Vincristine 0 1
Cytarabine + Methotrexate Cytarabine Methotrexate 0 3
Cytarabine + Methotrexate + Nelarabine + Pegaspargase + Venetoclax Cytarabine Methotrexate Nelarabine Pegaspargase Venetoclax 0 1
Cytarabine + Methotrexate + Ponatinib Cytarabine Methotrexate Ponatinib 0 2
Cytarabine + Methotrexate + Prednisone Cytarabine Methotrexate Prednisone 0 1
Cytarabine + Methotrexate + Rituximab Cytarabine Methotrexate Rituximab 0 1
Cytarabine + Methotrexate + Rituximab + Venetoclax Cytarabine Methotrexate Rituximab Venetoclax 0 1
Cytarabine + Methotrexate + Venetoclax Cytarabine Methotrexate Venetoclax 0 1
Daunorubicin + Dexamethasone + Methotrexate + Pegaspargase + Vincristine Daunorubicin Dexamethasone Methotrexate Pegaspargase Vincristine 0 1
Dexamethasone + Doxorubicin + Methotrexate + Pegaspargase + Vincristine Dexamethasone Doxorubicin Methotrexate Pegaspargase Vincristine 0 1
Dexamethasone + Leucovorin + Mercaptopurine + Methotrexate + Vincristine Dexamethasone Leucovorin Mercaptopurine Methotrexate Vincristine 0 1
Dexamethasone + Leucovorin + Methotrexate + Vincristine Dexamethasone Leucovorin Methotrexate Vincristine 0 0
Dexamethasone + Mercaptopurine + Methotrexate + Vincristine Dexamethasone Mercaptopurine Methotrexate Vincristine 0 1
Dexamethasone + Mercaptopurine + Methotrexate + Vincristine sulfate liposome Dexamethasone Mercaptopurine Methotrexate Vincristine sulfate liposome 0 1
Dexamethasone + Methotrexate + Mitoxantrone + Pegaspargase + Vincristine sulfate liposome Dexamethasone Methotrexate Mitoxantrone Pegaspargase Vincristine sulfate liposome 0 1
Dexamethasone + Methotrexate + Pegaspargase + Vincristine sulfate liposome Dexamethasone Methotrexate Pegaspargase Vincristine sulfate liposome 0 1
Filgrastim + Methotrexate Filgrastim Methotrexate 0 1
Filgrastim + Methotrexate + Rituximab Filgrastim Methotrexate Rituximab 0 1
Leucovorin + Mercaptopurine + Methotrexate + Vincristine Leucovorin Mercaptopurine Methotrexate Vincristine 0 1
Leucovorin + Methotrexate + Vincristine Leucovorin Methotrexate Vincristine 0 1
Mercaptopurine + Methotrexate + Prednisolone + Vincristine Mercaptopurine Methotrexate Prednisolone Vincristine 0 1
Mercaptopurine + Methotrexate + Prednisone + Venetoclax + Vincristine Mercaptopurine Methotrexate Prednisone Venetoclax Vincristine 0 1
Mercaptopurine + Methotrexate + Prednisone + Vincristine Mercaptopurine Methotrexate Prednisone Vincristine 0 6
Mercaptopurine + Methotrexate + Vincristine Mercaptopurine Methotrexate Vincristine 0 2
Methotrexate Methotrexate 0 38
Methotrexate + Pegaspargase Methotrexate Pegaspargase 0 1
Methotrexate + Pegaspargase + Venetoclax Methotrexate Pegaspargase Venetoclax 0 1
Methotrexate + Pegaspargase + Vincristine Methotrexate Pegaspargase Vincristine 0 1
Methotrexate + Regorafenib Methotrexate Regorafenib 0 1
Methotrexate + Ribociclib Methotrexate Ribociclib 2 0
Methotrexate + Sirolimus Methotrexate Sirolimus 0 1
Methotrexate + Sirolimus + Tacrolimus Methotrexate Sirolimus Tacrolimus 0 3
Methotrexate + Tacrolimus Methotrexate Tacrolimus 0 2
Methotrexate + UNC2025 Methotrexate UNC2025 0 0
Methotrexate + Vincristine Methotrexate Vincristine 0 1


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