Drug Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Methotrexate
Trade Name Abitrexate
Synonyms Amethopterin
Drug Descriptions

Methotrexate is an antimetabolite, which inhibits DHFR resulting in decreased immune function and antineoplastic activity and is FDA approved for psoriasis, RA, and several cancers including choriocarcinoma, AML, lung, head and neck and epidermoid (FDA.gov).

DrugClasses Chemotherapy - Antimetabolite 11

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Aldoxorubicin + Cisplatin + Filgrastim + Methotrexate + Vinblastine Aldoxorubicin Cisplatin Filgrastim Methotrexate Vinblastine 0 1
Aldoxorubicin + Cisplatin + Methotrexate + Vincristine Aldoxorubicin Cisplatin Methotrexate Vincristine 0 1
Arsenic trioxide + Cytarabine + Methotrexate + Tretinoin Arsenic trioxide Cytarabine Methotrexate Tretinoin 1 0
Blinatumomab + Cytarabine + Dexamethasone + Methotrexate + Ponatinib Blinatumomab Cytarabine Dexamethasone Methotrexate Ponatinib 0 1
Blinatumomab + Dasatinib + Methotrexate Blinatumomab Dasatinib Methotrexate 0 1
Blinatumomab + Dexamethasone + Leucovorin + Methotrexate Blinatumomab Dexamethasone Leucovorin Methotrexate 0 1
Blinatumomab + Dexamethasone + Methotrexate Blinatumomab Dexamethasone Methotrexate 0 1
Blinatumomab + Leucovorin + Methotrexate Blinatumomab Leucovorin Methotrexate 0 1
Blinatumomab + Mercaptopurine + Methotrexate + Prednisone + Vincristine Blinatumomab Mercaptopurine Methotrexate Prednisone Vincristine 0 1
Blinatumomab + Methotrexate Blinatumomab Methotrexate 0 1
Busulfan + Fludarabine + GVAX + Methotrexate + Tacrolimus Busulfan Fludarabine GVAX Methotrexate Tacrolimus 0 1
Busulfan + Fludarabine + Methotrexate + Tacrolimus Busulfan Fludarabine Methotrexate Tacrolimus 0 1
Calaspargase pegol-mknl + Dexamethasone + Etoposide + Ifosfamide + Methotrexate Calaspargase pegol-mknl Dexamethasone Etoposide Ifosfamide Methotrexate 0 1
Carboplatin + Cyclophosphamide + Methotrexate + Vincristine Carboplatin Cyclophosphamide Methotrexate Vincristine 0 1
Carboplatin + Methotrexate + Rituximab Carboplatin Methotrexate Rituximab 0 1
Cetuximab + Docetaxel + Methotrexate Cetuximab Docetaxel Methotrexate 0 0
Cetuximab + Methotrexate Cetuximab Methotrexate 0 0
Cisplatin + Cyclophosphamide + Methotrexate + Vincristine Cisplatin Cyclophosphamide Methotrexate Vincristine 0 2
Cisplatin + Doxorubicin + Durvalumab + Methotrexate + Vinblastine Cisplatin Doxorubicin Durvalumab Methotrexate Vinblastine 0 1
Cisplatin + Doxorubicin + Methotrexate + Pegfilgrastim + Pembrolizumab + Vinblastine Cisplatin Doxorubicin Methotrexate Pegfilgrastim Pembrolizumab Vinblastine 0 1
Cyclophosphamide + Cytarabine + Dexamethasone + Doxorubicin + Imatinib + Methotrexate + Vincristine Cyclophosphamide Cytarabine Dexamethasone Doxorubicin Imatinib Methotrexate Vincristine 0 0
Cyclophosphamide + Cytarabine + Dexamethasone + Doxorubicin + Leucovorin + Methotrexate + Pegaspargase + Thioguanine + Vincristine Cyclophosphamide Cytarabine Dexamethasone Doxorubicin Leucovorin Methotrexate Pegaspargase Thioguanine Vincristine 0 1
Cyclophosphamide + Cytarabine + Dexamethasone + Doxorubicin + Leucovorin + Methotrexate + Pegaspargase + Vincristine Cyclophosphamide Cytarabine Dexamethasone Doxorubicin Leucovorin Methotrexate Pegaspargase Vincristine 0 0
Cyclophosphamide + Cytarabine + Dexamethasone + Doxorubicin + Methotrexate + Ofatumumab + Vincristine Cyclophosphamide Cytarabine Dexamethasone Doxorubicin Methotrexate Ofatumumab Vincristine 0 1
Cyclophosphamide + Cytarabine + Dexamethasone + Doxorubicin + Methotrexate + Pegaspargase + Thioguanine + Vincristine Cyclophosphamide Cytarabine Dexamethasone Doxorubicin Methotrexate Pegaspargase Thioguanine Vincristine 0 1
Cyclophosphamide + Cytarabine + Dexamethasone + Doxorubicin + Methotrexate + Rituximab + Venetoclax + Vincristine Cyclophosphamide Cytarabine Dexamethasone Doxorubicin Methotrexate Rituximab Venetoclax Vincristine 0 1
Cyclophosphamide + Cytarabine + Dexamethasone + Doxorubicin + Methotrexate + Rituximab + Vincristine Cyclophosphamide Cytarabine Dexamethasone Doxorubicin Methotrexate Rituximab Vincristine 0 1
Cyclophosphamide + Cytarabine + Dexamethasone + Doxorubicin + Methotrexate + Vincristine Cyclophosphamide Cytarabine Dexamethasone Doxorubicin Methotrexate Vincristine 0 1
Cyclophosphamide + Cytarabine + Dexamethasone + Methotrexate + Rituximab + Venetoclax + Vincristine Cyclophosphamide Cytarabine Dexamethasone Methotrexate Rituximab Venetoclax Vincristine 0 1
Cyclophosphamide + Cytarabine + Doxorubicin + Etoposide + Filgrastim + Ifosfamide + Leucovorin + Mesna + Methotrexate + Rituximab + Vincristine Cyclophosphamide Cytarabine Doxorubicin Etoposide Filgrastim Ifosfamide Leucovorin Mesna Methotrexate Rituximab Vincristine 0 1
Cyclophosphamide + Cytarabine + Hydrocortisone + Mercaptopurine + Methotrexate Cyclophosphamide Cytarabine Hydrocortisone Mercaptopurine Methotrexate 0 1
Cyclophosphamide + Cytarabine + inotuzumab ozogamicin + Methotrexate + Vincristine Cyclophosphamide Cytarabine Methotrexate Vincristine inotuzumab ozogamicin 0 1
Cyclophosphamide + Cytarabine + Leucovorin + Mercaptopurine + Methotrexate + Pegaspargase + Vincristine Cyclophosphamide Cytarabine Leucovorin Mercaptopurine Methotrexate Pegaspargase Vincristine 0 1
Cyclophosphamide + Cytarabine + Mercaptopurine + Methotrexate + Pegaspargase + Vincristine Cyclophosphamide Cytarabine Mercaptopurine Methotrexate Pegaspargase Vincristine 0 2
Cyclophosphamide + Cytarabine + Methotrexate + Pegaspargase + Thioguanine + Vincristine Cyclophosphamide Cytarabine Methotrexate Pegaspargase Thioguanine Vincristine 0 1
Cyclophosphamide + Dexamethasone + Doxorubicin + Methotrexate + Rituximab + Venetoclax + Vincristine Cyclophosphamide Dexamethasone Doxorubicin Methotrexate Rituximab Venetoclax Vincristine 0 1
Cyclophosphamide + Dexamethasone + Methotrexate + Rituximab + Venetoclax + Vincristine Cyclophosphamide Dexamethasone Methotrexate Rituximab Venetoclax Vincristine 0 1
Cyclophosphamide + Methotrexate + Pegaspargase + Vincristine Cyclophosphamide Methotrexate Pegaspargase Vincristine 0 2
Cyclophosphamide + Methotrexate + Vandetanib Cyclophosphamide Methotrexate Vandetanib 1 0
Cyclophosphamide + Methotrexate + Vincristine Cyclophosphamide Methotrexate Vincristine 0 1
Cytarabine + Daunorubicin + Dexamethasone + Hydrocortisone + Methotrexate + Pegaspargase + Prednisolone + Vincristine Cytarabine Daunorubicin Dexamethasone Hydrocortisone Methotrexate Pegaspargase Prednisolone Vincristine 0 1
Cytarabine + Daunorubicin + Dexamethasone + Methotrexate + Pegaspargase + Vincristine Cytarabine Daunorubicin Dexamethasone Methotrexate Pegaspargase Vincristine 0 1
Cytarabine + Daunorubicin + Fludarabine + Hydrocortisone + Methotrexate + Quizartinib Cytarabine Daunorubicin Fludarabine Hydrocortisone Methotrexate Quizartinib 0 1
Cytarabine + Daunorubicin + Fludarabine + Methotrexate + Prednisolone + Quizartinib Cytarabine Daunorubicin Fludarabine Methotrexate Prednisolone Quizartinib 0 1
Cytarabine + Daunorubicin + inotuzumab ozogamicin + Methotrexate + Pegaspargase + Prednisone + Vincristine Cytarabine Daunorubicin Methotrexate Pegaspargase Prednisone Vincristine inotuzumab ozogamicin 0 0
Cytarabine + Daunorubicin + inotuzumab ozogamicin + Methotrexate + Prednisone + Vincristine Cytarabine Daunorubicin Methotrexate Prednisone Vincristine inotuzumab ozogamicin 0 0
Cytarabine + Daunorubicin + Methotrexate + Pegaspargase + Prednisolone + Vincristine Cytarabine Daunorubicin Methotrexate Pegaspargase Prednisolone Vincristine 0 1
Cytarabine + Dexamethasone + Methotrexate Cytarabine Dexamethasone Methotrexate 0 3
Cytarabine + Dexamethasone + Methotrexate + Pegaspargase + Vincristine Cytarabine Dexamethasone Methotrexate Pegaspargase Vincristine 0 1
Cytarabine + Dexamethasone + Methotrexate + Ponatinib + Rituximab + Venetoclax Cytarabine Dexamethasone Methotrexate Ponatinib Rituximab Venetoclax 0 1
Cytarabine + Dexamethasone + Methotrexate + Vincristine Cytarabine Dexamethasone Methotrexate Vincristine 0 0
Cytarabine + Doxorubicin + Methotrexate + Vincristine Cytarabine Doxorubicin Methotrexate Vincristine 0 1
Cytarabine + Etoposide + Methotrexate Cytarabine Etoposide Methotrexate 0 1
Cytarabine + Fludarabine + Methotrexate + Prednisolone Cytarabine Fludarabine Methotrexate Prednisolone 0 1
Cytarabine + Fludarabine + Methotrexate + Prednisolone + Quizartinib Cytarabine Fludarabine Methotrexate Prednisolone Quizartinib 0 1
Cytarabine + Fludarabine + Methotrexate + Prednisone + Selinexor Cytarabine Fludarabine Methotrexate Prednisone Selinexor 0 1
Cytarabine + Hydrocortisone + Idasanutlin + Methotrexate + Venetoclax Cytarabine Hydrocortisone Idasanutlin Methotrexate Venetoclax 0 0
Cytarabine + Hydrocortisone + Mercaptopurine + Methotrexate Cytarabine Hydrocortisone Mercaptopurine Methotrexate 0 1
Cytarabine + Hydrocortisone + Methotrexate Cytarabine Hydrocortisone Methotrexate 0 4
Cytarabine + Imatinib + Methotrexate Cytarabine Imatinib Methotrexate 0 1
Cytarabine + inotuzumab ozogamicin + Methotrexate Cytarabine Methotrexate inotuzumab ozogamicin 0 1
Cytarabine + Leucovorin + Methotrexate Cytarabine Leucovorin Methotrexate 0 2
Cytarabine + Leucovorin + Methotrexate + Pegaspargase + Vincristine Cytarabine Leucovorin Methotrexate Pegaspargase Vincristine 0 1
Cytarabine + Methotrexate Cytarabine Methotrexate 0 3
Cytarabine + Methotrexate + Methylprednisolone + Rituximab + Venetoclax Cytarabine Methotrexate Methylprednisolone Rituximab Venetoclax 0 1
Cytarabine + Methotrexate + Nelarabine + Pegaspargase + Venetoclax Cytarabine Methotrexate Nelarabine Pegaspargase Venetoclax 0 1
Cytarabine + Methotrexate + Ponatinib Cytarabine Methotrexate Ponatinib 0 2
Cytarabine + Methotrexate + Prednisone Cytarabine Methotrexate Prednisone 0 1
Cytarabine + Methotrexate + Rituximab Cytarabine Methotrexate Rituximab 0 1
Cytarabine + Methotrexate + Rituximab + Venetoclax Cytarabine Methotrexate Rituximab Venetoclax 0 2
Cytarabine + Methotrexate + Venetoclax Cytarabine Methotrexate Venetoclax 0 1
Dasatinib + Dexamethasone + Hydrocortisone + Methotrexate Dasatinib Dexamethasone Hydrocortisone Methotrexate 0 0
Dasatinib + Dexamethasone + Methotrexate Dasatinib Dexamethasone Methotrexate 0 1
Daunorubicin + Dexamethasone + Methotrexate + Pegaspargase + Vincristine Daunorubicin Dexamethasone Methotrexate Pegaspargase Vincristine 0 1
Dexamethasone + Doxorubicin + Methotrexate + Pegaspargase + Vincristine Dexamethasone Doxorubicin Methotrexate Pegaspargase Vincristine 0 2
Dexamethasone + Leucovorin + Mercaptopurine + Methotrexate + Vincristine Dexamethasone Leucovorin Mercaptopurine Methotrexate Vincristine 0 1
Dexamethasone + Leucovorin + Methotrexate + Vincristine Dexamethasone Leucovorin Methotrexate Vincristine 0 0
Dexamethasone + Mercaptopurine + Methotrexate + Vincristine Dexamethasone Mercaptopurine Methotrexate Vincristine 0 1
Dexamethasone + Mercaptopurine + Methotrexate + Vincristine sulfate liposome Dexamethasone Mercaptopurine Methotrexate Vincristine sulfate liposome 0 1
Dexamethasone + Methotrexate + Mitoxantrone + Pegaspargase + Vincristine sulfate liposome Dexamethasone Methotrexate Mitoxantrone Pegaspargase Vincristine sulfate liposome 0 1
Dexamethasone + Methotrexate + Pegaspargase + Vincristine sulfate liposome Dexamethasone Methotrexate Pegaspargase Vincristine sulfate liposome 0 1
Filgrastim + Methotrexate Filgrastim Methotrexate 0 1
Filgrastim + Methotrexate + Rituximab Filgrastim Methotrexate Rituximab 0 1
Glucarpidase + Leucovorin + Methotrexate + Rituximab Glucarpidase Leucovorin Methotrexate Rituximab 0 1
Idasanutlin + Methotrexate + Venetoclax Idasanutlin Methotrexate Venetoclax 0 0
inotuzumab ozogamicin + Methotrexate Methotrexate inotuzumab ozogamicin 0 1
Leucovorin + Mercaptopurine + Methotrexate + Vincristine Leucovorin Mercaptopurine Methotrexate Vincristine 0 2
Leucovorin + Methotrexate + Vincristine Leucovorin Methotrexate Vincristine 0 1
Mercaptopurine + Methotrexate Mercaptopurine Methotrexate 0 1
Mercaptopurine + Methotrexate + Prednisolone + Vincristine Mercaptopurine Methotrexate Prednisolone Vincristine 0 2
Mercaptopurine + Methotrexate + Prednisone + tagraxofusp-erzs + Venetoclax + Vincristine Mercaptopurine Methotrexate Prednisone Venetoclax Vincristine tagraxofusp-erzs 0 1
Mercaptopurine + Methotrexate + Prednisone + Venetoclax + Vincristine Mercaptopurine Methotrexate Prednisone Venetoclax Vincristine 0 1
Mercaptopurine + Methotrexate + Prednisone + Vincristine Mercaptopurine Methotrexate Prednisone Vincristine 0 6
Mercaptopurine + Methotrexate + Vincristine Mercaptopurine Methotrexate Vincristine 0 2
Methotrexate Methotrexate 0 40
Methotrexate + Pegaspargase Methotrexate Pegaspargase 0 1
Methotrexate + Pegaspargase + Venetoclax Methotrexate Pegaspargase Venetoclax 0 1
Methotrexate + Pegaspargase + Vincristine Methotrexate Pegaspargase Vincristine 0 2
Methotrexate + Regorafenib Methotrexate Regorafenib 0 1
Methotrexate + Ribociclib Methotrexate Ribociclib 2 0
Methotrexate + Sirolimus Methotrexate Sirolimus 0 1
Methotrexate + Sirolimus + Tacrolimus Methotrexate Sirolimus Tacrolimus 0 3
Methotrexate + Tacrolimus Methotrexate Tacrolimus 0 2
Methotrexate + UNC2025 Methotrexate UNC2025 0 0
Methotrexate + Vincristine Methotrexate Vincristine 0 1


Additional content available in CKB BOOST