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Drug Name Venetoclax
Trade Name Venclexta
Synonyms ABT-199|RG7601|GDC-0199|ABT119
Drug Descriptions

Venclexta (venetoclax) is a BH3-mimetic that binds to and inhibits BCL2, resulting in increased tumor cell apoptosis (PMID: 26589495, PMID: 25048785). Venclexta (venetoclax) is FDA approved for use in patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL), and in combination with chemotherapy in patients 75 years old or older with newly-diagnosed acute myeloid leukemia (FDA.gov).

DrugClasses BCL2 inhibitor 17

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Therapy Name Drugs Efficacy Evidence Clinical Trials
A-1210477 + Venetoclax A-1210477 Venetoclax 1 0
Acalabrutinib + Obinutuzumab + Venetoclax Acalabrutinib Obinutuzumab Venetoclax 0 3
Acalabrutinib + Venetoclax Acalabrutinib Venetoclax 0 2
Ado-trastuzumab emtansine + Venetoclax Ado-trastuzumab emtansine Venetoclax 0 1
Alisertib + Venetoclax Alisertib Venetoclax 0 0
Allopurinol + Ibrutinib + Venetoclax Allopurinol Ibrutinib Venetoclax 0 1
Alvocidib + Venetoclax Alvocidib Venetoclax 0 1
AMG 176 + Venetoclax AMG 176 Venetoclax 0 1
APR-246 + Azacitidine + Venetoclax APR-246 Azacitidine Venetoclax 0 1
ARGX-110 + Azacitidine + Venetoclax ARGX-110 Azacitidine Venetoclax 0 1
ARGX-110 + Venetoclax ARGX-110 Venetoclax 0 1
ARQ 531 + Venetoclax ARQ 531 Venetoclax 0 0
Azacitidine + CC-90009 + Venetoclax Azacitidine CC-90009 Venetoclax 0 1
Azacitidine + Cladribine + Cytarabine + Venetoclax Azacitidine Cladribine Cytarabine Venetoclax 0 1
Azacitidine + Gilteritinib + Venetoclax Azacitidine Gilteritinib Venetoclax 0 1
Azacitidine + IMGN632 + Venetoclax Azacitidine IMGN632 Venetoclax 0 1
Azacitidine + MLN4924 + Venetoclax Azacitidine MLN4924 Venetoclax 0 2
Azacitidine + Salsalate + Venetoclax Azacitidine Salsalate Venetoclax 0 1
Azacitidine + tagraxofusp-erzs + Venetoclax Azacitidine Venetoclax tagraxofusp-erzs 0 1
Azacitidine + Venetoclax Azacitidine Venetoclax 4 12
Bendamustine + Obinutuzumab + Venetoclax Bendamustine Obinutuzumab Venetoclax 1 3
Bendamustine + Rituximab + Venetoclax Bendamustine Rituximab Venetoclax 0 3
BEZ235 + Venetoclax BEZ235 Venetoclax 2 0
Bortezomib + Daratumumab + Dexamethasone + Venetoclax Bortezomib Daratumumab Dexamethasone Venetoclax 0 2
Bortezomib + Dexamethasone + Venetoclax Bortezomib Dexamethasone Venetoclax 0 2
Bortezomib + Rituximab + Venetoclax Bortezomib Rituximab Venetoclax 0 1
Buparlisib + Venetoclax Buparlisib Venetoclax 0 0
Busulfan + Fludarabine + Venetoclax Busulfan Fludarabine Venetoclax 0 1
Busulfan + Venetoclax Busulfan Venetoclax 0 1
Capecitabine + Venetoclax Capecitabine Venetoclax 0 1
Capmatinib + Venetoclax Capmatinib Venetoclax 0 0
Carboplatin + Etoposide + Ifosfamide + Rituximab + Venetoclax Carboplatin Etoposide Ifosfamide Rituximab Venetoclax 0 1
Carfilzomib + Dexamethasone + Venetoclax Carfilzomib Dexamethasone Venetoclax 0 1
Carmustine + Cytarabine + Etoposide + Melphalan + Venetoclax Carmustine Cytarabine Etoposide Melphalan Venetoclax 0 2
Cerdulatinib + Venetoclax Cerdulatinib Venetoclax 1 0
Cobimetinib + Venetoclax Cobimetinib Venetoclax 0 1
CPX-351 + Venetoclax CPX-351 Venetoclax 0 3
CUDC-907 + Venetoclax CUDC-907 Venetoclax 0 1
CYC065 + Venetoclax CYC065 Venetoclax 0 1
Cyclophosphamide + Cytarabine + Dexamethasone + Doxorubicin + Methotrexate + Rituximab + Venetoclax + Vincristine Cyclophosphamide Cytarabine Dexamethasone Doxorubicin Methotrexate Rituximab Venetoclax Vincristine 0 1
Cyclophosphamide + Cytarabine + Dexamethasone + Methotrexate + Rituximab + Venetoclax + Vincristine Cyclophosphamide Cytarabine Dexamethasone Methotrexate Rituximab Venetoclax Vincristine 0 1
Cyclophosphamide + Dexamethasone + Doxorubicin + Methotrexate + Rituximab + Venetoclax + Vincristine Cyclophosphamide Dexamethasone Doxorubicin Methotrexate Rituximab Venetoclax Vincristine 0 1
Cyclophosphamide + Dexamethasone + Doxorubicin + Nelarabine + Pegaspargase + Venetoclax + Vincristine Cyclophosphamide Dexamethasone Doxorubicin Nelarabine Pegaspargase Venetoclax Vincristine 0 1
Cyclophosphamide + Dexamethasone + Methotrexate + Rituximab + Venetoclax + Vincristine Cyclophosphamide Dexamethasone Methotrexate Rituximab Venetoclax Vincristine 0 1
Cyclophosphamide + Dexamethasone + Rituximab + Venetoclax + Vincristine Cyclophosphamide Dexamethasone Rituximab Venetoclax Vincristine 0 1
Cyclophosphamide + Dexamethasone + Venetoclax + Vincristine Cyclophosphamide Dexamethasone Venetoclax Vincristine 0 1
Cyclophosphamide + Doxorubicin + Etoposide + Prednisone + Rituximab + Venetoclax + Vincristine Cyclophosphamide Doxorubicin Etoposide Prednisone Rituximab Venetoclax Vincristine 0 2
Cyclophosphamide + Doxorubicin + Prednisone + Rituximab + Venetoclax + Vincristine Cyclophosphamide Doxorubicin Prednisone Rituximab Venetoclax Vincristine 0 1
Cytarabine + Daunorubicin + Venetoclax Cytarabine Daunorubicin Venetoclax 0 1
Cytarabine + Dexamethasone + Methotrexate + Ponatinib + Rituximab + Venetoclax Cytarabine Dexamethasone Methotrexate Ponatinib Rituximab Venetoclax 0 1
Cytarabine + Filgrastim + Fludarabine + Idarubicin + Venetoclax Cytarabine Filgrastim Fludarabine Idarubicin Venetoclax 0 1
Cytarabine + Hydrocortisone + Idasanutlin + Methotrexate + Venetoclax Cytarabine Hydrocortisone Idasanutlin Methotrexate Venetoclax 0 0
Cytarabine + Idarubicin + Venetoclax Cytarabine Idarubicin Venetoclax 0 0
Cytarabine + Idasanutlin + Venetoclax Cytarabine Idasanutlin Venetoclax 0 0
Cytarabine + Methotrexate + Methylprednisolone + Rituximab + Venetoclax Cytarabine Methotrexate Methylprednisolone Rituximab Venetoclax 0 1
Cytarabine + Methotrexate + Nelarabine + Pegaspargase + Venetoclax Cytarabine Methotrexate Nelarabine Pegaspargase Venetoclax 0 1
Cytarabine + Methotrexate + Rituximab + Venetoclax Cytarabine Methotrexate Rituximab Venetoclax 0 2
Cytarabine + Methotrexate + Venetoclax Cytarabine Methotrexate Venetoclax 0 1
Cytarabine + Venetoclax Cytarabine Venetoclax 9 2
Daratumumab + Dexamethasone + Venetoclax Daratumumab Dexamethasone Venetoclax 0 1
Dasatinib + Venetoclax Dasatinib Venetoclax 0 1
Daunorubicin + Venetoclax Daunorubicin Venetoclax 1 0
Decitabine + Nivolumab + Venetoclax Decitabine Nivolumab Venetoclax 0 1
Decitabine + Ponatinib + Venetoclax Decitabine Ponatinib Venetoclax 0 1
Decitabine + Salsalate + Venetoclax Decitabine Salsalate Venetoclax 0 1
Decitabine + Venetoclax Decitabine Venetoclax 4 5
Dexamethasone + Ixazomib + Pomalidomide + Venetoclax Dexamethasone Ixazomib Pomalidomide Venetoclax 0 1
Dexamethasone + Lenalidomide + Venetoclax Dexamethasone Lenalidomide Venetoclax 0 1
Dexamethasone + Pomalidomide + Venetoclax Dexamethasone Pomalidomide Venetoclax 0 1
Dexamethasone + Venetoclax Dexamethasone Venetoclax 0 1
Dinaciclib + Venetoclax Dinaciclib Venetoclax 0 1
DT2216 + Venetoclax DT2216 Venetoclax 1 0
Duvelisib + Venetoclax Duvelisib Venetoclax 0 2
Enasidenib + Venetoclax Enasidenib Venetoclax 0 1
Enzalutamide + Venetoclax Enzalutamide Venetoclax 0 1
Ethinylestradiol + Levonorgestrel + Venetoclax Ethinylestradiol Levonorgestrel Venetoclax 0 1
Fulvestrant + Venetoclax Fulvestrant Venetoclax 0 1
G-TPP + Venetoclax G-TPP Venetoclax 2 0
Gemtuzumab ozogamicin + Venetoclax Gemtuzumab ozogamicin Venetoclax 0 1
Gilteritinib + Venetoclax Gilteritinib Venetoclax 0 1
GS-5829 + Venetoclax GS-5829 Venetoclax 2 0
GSK690693 + Venetoclax GSK690693 Venetoclax 1 0
HDM201 + Venetoclax HDM201 Venetoclax 0 1
Hyaluronidase + Rituximab + Venetoclax Hyaluronidase Rituximab Venetoclax 0 1
Ibrutinib + Lenalidomide + Obinutuzumab + Prednisone + Venetoclax Ibrutinib Lenalidomide Obinutuzumab Prednisone Venetoclax 0 1
Ibrutinib + Obinutuzumab + Venetoclax Ibrutinib Obinutuzumab Venetoclax 0 3
Ibrutinib + Rituximab + Venetoclax Ibrutinib Rituximab Venetoclax 0 2
Ibrutinib + Venetoclax Ibrutinib Venetoclax 5 12
Idasanutlin + Methotrexate + Venetoclax Idasanutlin Methotrexate Venetoclax 0 0
Idasanutlin + Obinutuzumab + Rituximab + Venetoclax Idasanutlin Obinutuzumab Rituximab Venetoclax 0 1
Idasanutlin + Obinutuzumab + Venetoclax Idasanutlin Obinutuzumab Venetoclax 0 1
Idasanutlin + Rituximab + Venetoclax Idasanutlin Rituximab Venetoclax 0 1
Idasanutlin + Venetoclax Idasanutlin Venetoclax 0 1
Idelalisib + Rituximab + Venetoclax Idelalisib Rituximab Venetoclax 0 1
Imatinib + Venetoclax Imatinib Venetoclax 0 0
IMGN632 + Venetoclax IMGN632 Venetoclax 0 1
Ivosidenib + Venetoclax Ivosidenib Venetoclax 0 1
LAM-003 + Venetoclax LAM-003 Venetoclax 1 0
Lenalidomide + Obinutuzumab + Venetoclax Lenalidomide Obinutuzumab Venetoclax 0 2
Lenalidomide + Rituximab + Venetoclax Lenalidomide Rituximab Venetoclax 0 1
LOXO-305 + Rituximab + Venetoclax LOXO-305 Rituximab Venetoclax 0 1
LOXO-305 + Venetoclax LOXO-305 Venetoclax 0 1
Mercaptopurine + Methotrexate + Prednisone + tagraxofusp-erzs + Venetoclax + Vincristine Mercaptopurine Methotrexate Prednisone Venetoclax Vincristine tagraxofusp-erzs 0 1
Mercaptopurine + Methotrexate + Prednisone + Venetoclax + Vincristine Mercaptopurine Methotrexate Prednisone Venetoclax Vincristine 0 1
Methotrexate + Pegaspargase + Venetoclax Methotrexate Pegaspargase Venetoclax 0 1
Mivebresib + Venetoclax Mivebresib Venetoclax 1 0
MK2206 + Venetoclax MK2206 Venetoclax 1 0
MT-3724 + Venetoclax MT-3724 Venetoclax 0 0
Navitoclax + Venetoclax Navitoclax Venetoclax 0 1
Nelarabine + Pegaspargase + Venetoclax Nelarabine Pegaspargase Venetoclax 0 1
Nilotinib + Venetoclax Nilotinib Venetoclax 0 0
Obinutuzumab + Polatuzumab vedotin-piiq + Venetoclax Obinutuzumab Polatuzumab vedotin-piiq Venetoclax 0 1
Obinutuzumab + Venetoclax Obinutuzumab Venetoclax 1 5
Obinutuzumab + Venetoclax + Zanubrutinib Obinutuzumab Venetoclax Zanubrutinib 0 1
ONC201 + Venetoclax ONC201 Venetoclax 2 0
Pembrolizumab + Venetoclax Pembrolizumab Venetoclax 0 1
Pictilisib + Venetoclax Pictilisib Venetoclax 0 0
Ponatinib + Venetoclax Ponatinib Venetoclax 0 0
PQR309 + Venetoclax PQR309 Venetoclax 1 0
Prednisone + Venetoclax + Vincristine Prednisone Venetoclax Vincristine 0 1
Quizartinib + Venetoclax Quizartinib Venetoclax 0 1
Rituximab + TEN-010 + Venetoclax Rituximab TEN-010 Venetoclax 0 1
Rituximab + Venetoclax Rituximab Venetoclax 1 2
RO5503781 + Venetoclax RO5503781 Venetoclax 0 1
Ruxolitinib + Venetoclax Ruxolitinib Venetoclax 0 1
sapacitabine + Venetoclax Venetoclax sapacitabine 0 1
Selinexor + Venetoclax Selinexor Venetoclax 0 1
SY-1365 + Venetoclax SY-1365 Venetoclax 1 0
Tafasitamab + Venetoclax Tafasitamab Venetoclax 0 1
tagraxofusp-erzs + Venetoclax Venetoclax tagraxofusp-erzs 0 1
TAK-659 + Venetoclax TAK-659 Venetoclax 0 1
Tamoxifen + Venetoclax Tamoxifen Venetoclax 0 0
Tozasertib + Venetoclax Tozasertib Venetoclax 0 0
Trabectedin + Venetoclax Trabectedin Venetoclax 1 1
Ublituximab + Umbralisib + Venetoclax Ublituximab Umbralisib Venetoclax 0 3
Venetoclax Venetoclax 9 21
Venetoclax + Vincristine Venetoclax Vincristine 0 1
Venetoclax + VU661013 VU661013 Venetoclax 0 0
Venetoclax + VX-11e VX-11e Venetoclax 1 0


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