Drug Detail


Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Loncastuximab tesirine
Trade Name Lonca
Synonyms ADCT-402
Drug Descriptions

Loncastuximab tesirine (ADCT-402) is a human anti-CD19 antibody in conjugation with a pyrrolobenzodiazepine (PBD) dimer toxin, which may specifically target CD19-positive tumor cells (Blood 2017 130(Suppl 1):187, PMID: 32012214).

DrugClasses CD19 Antibody 12
CAS Registry Number 1879918-31-6
NCIT ID C125549


  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"


  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Durvalumab + Loncastuximab tesirine Durvalumab Loncastuximab tesirine 0 1
Ibrutinib + Loncastuximab tesirine Ibrutinib Loncastuximab tesirine 0 1
Loncastuximab tesirine Loncastuximab tesirine 3 1
Loncastuximab tesirine + Rituximab Loncastuximab tesirine Rituximab 0 1

Additional content available in CKB BOOST