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Drug Name Loncastuximab tesirine-lpyl
Trade Name Zynlonta
Synonyms ADCT-402
Drug Descriptions

Zynlonta (loncastuximab tesirine-lpyl) is a human anti-CD19 antibody in conjugation with a pyrrolobenzodiazepine (PBD) dimer toxin, which may specifically target CD19-positive tumor cells (Blood 2017 130(Suppl 1):187, PMID: 32012214). Zynlonta (loncastuximab tesirine-lpyl) is FDA approved for use in patients with relapsed or refractory large B-cell lymphoma after two or more lines of systemic therapy (FDA.gov).

DrugClasses CD19 Antibody 14
CAS Registry Number 1879918-31-6
NCIT ID C125549

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Cyclophosphamide + Doxorubicin + Etoposide + Loncastuximab tesirine-lpyl + Prednisone + Rituximab + Vincristine Sulfate Cyclophosphamide Doxorubicin Etoposide Loncastuximab tesirine-lpyl Prednisone Rituximab Vincristine Sulfate 0 2
Durvalumab + Loncastuximab tesirine-lpyl Durvalumab Loncastuximab tesirine-lpyl 0 1
Gemcitabine + Loncastuximab tesirine-lpyl Gemcitabine Loncastuximab tesirine-lpyl 0 1
Ibrutinib + Loncastuximab tesirine-lpyl Ibrutinib Loncastuximab tesirine-lpyl 0 1
Idelalisib + Loncastuximab tesirine-lpyl Idelalisib Loncastuximab tesirine-lpyl 0 0
Lenalidomide + Loncastuximab tesirine-lpyl Lenalidomide Loncastuximab tesirine-lpyl 0 1
Loncastuximab tesirine-lpyl Loncastuximab tesirine-lpyl 0 5
Loncastuximab tesirine-lpyl + Polatuzumab vedotin-piiq Loncastuximab tesirine-lpyl Polatuzumab vedotin-piiq 0 1
Loncastuximab tesirine-lpyl + Rituximab Loncastuximab tesirine-lpyl Rituximab 0 3
Loncastuximab tesirine-lpyl + Umbralisib Loncastuximab tesirine-lpyl Umbralisib 0 1
Loncastuximab tesirine-lpyl + Venetoclax Loncastuximab tesirine-lpyl Venetoclax 0 1


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