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Drug Name Ibrutinib
Trade Name Imbruvica
Synonyms PCI-32765
Drug Descriptions

Imbruvica (ibrutinib) is a selective, irreversible inhibitor of Bruton's tyrosine kinase (BTK), which promotes apoptosis and inhibits B-cell mediated signaling pathways, and has additional activity against ERBB2 (HER2) and EGFR (PMID: 20615965, PMID: 21422473, PMID: 27678331). Imbruvica (Ibrutinib) is FDA approved for use in patients with mantle cell lymphoma, CLL/SLL and CLL/SLL with del 17p, Waldenstroem’s macroglobulinemia, marginal zone lymphoma, and in combination with Rituxan (rituximab) for untreated CLL/SLL (FDA.gov).

DrugClasses BTK inhibitor 22 EGFR Inhibitor (Pan) 46 HER2 Inhibitor 23

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abexinostat + Ibrutinib Abexinostat Ibrutinib 0 1
Allopurinol + Ibrutinib + Venetoclax Allopurinol Ibrutinib Venetoclax 0 0
APG-2575 + Ibrutinib APG-2575 Ibrutinib 2 0
Avelumab + Ibrutinib + Rituximab + Utomilumab Avelumab Ibrutinib Rituximab Utomilumab 0 1
Azacitidine + Ibrutinib Azacitidine Ibrutinib 0 1
AZD6738 + Ibrutinib AZD6738 Ibrutinib 1 0
BI 836826 + Ibrutinib BI 836826 Ibrutinib 0 1
Blinatumomab + Ibrutinib Blinatumomab Ibrutinib 0 1
BNC105P + Ibrutinib BNC105P Ibrutinib 0 1
Bortezomib + Ibrutinib Bortezomib Ibrutinib 0 1
Brentuximab vedotin + Ibrutinib Brentuximab vedotin Ibrutinib 0 1
Buparlisib + Ibrutinib Buparlisib Ibrutinib 3 2
Carfilzomib + Ibrutinib Carfilzomib Ibrutinib 0 2
Cetuximab + Ibrutinib Cetuximab Ibrutinib 0 2
Cirmtuzumab + Ibrutinib Cirmtuzumab Ibrutinib 0 1
Copanlisib + Ibrutinib Copanlisib Ibrutinib 0 2
Cyclophosphamide + Doxorubicin + Etoposide + Filgrastim + Ibrutinib + Pegfilgrastim + Prednisone + Rituximab + Vincristine Sulfate Cyclophosphamide Doxorubicin Etoposide Filgrastim Ibrutinib Pegfilgrastim Prednisone Rituximab Vincristine Sulfate 0 1
Cyclophosphamide + Fludarabine + Ibrutinib + Obinutuzumab Cyclophosphamide Fludarabine Ibrutinib Obinutuzumab 0 1
Cyclophosphamide + Fludarabine + Ibrutinib + Rituximab Cyclophosphamide Fludarabine Ibrutinib Rituximab 0 1
Cytarabine + Dexamethasone + Etoposide + Ibrutinib + Isavuconazole + Pegylated liposomal-doxorubicin + Rituximab + Temozolomide Cytarabine Dexamethasone Etoposide Ibrutinib Isavuconazole Pegylated liposomal-doxorubicin Rituximab Temozolomide 0 1
Cytarabine + Ibrutinib + Idarubicin Cytarabine Ibrutinib Idarubicin 0 1
Daratumumab + Ibrutinib Daratumumab Ibrutinib 0 3
Dasatinib + Ibrutinib + Prednisone Dasatinib Ibrutinib Prednisone 0 1
Dexamethasone + Etoposide + Ibrutinib + Pegylated liposomal-doxorubicin + Rituximab + Temozolomide Dexamethasone Etoposide Ibrutinib Pegylated liposomal-doxorubicin Rituximab Temozolomide 0 0
Dexamethasone + Etoposide + Ibrutinib + Pegylated liposomal-doxorubicin + Temozolomide Dexamethasone Etoposide Ibrutinib Pegylated liposomal-doxorubicin Temozolomide 0 1
Dexamethasone + Ibrutinib + Lenalidomide Dexamethasone Ibrutinib Lenalidomide 0 2
Docetaxel + Ibrutinib Docetaxel Ibrutinib 0 1
Dubermatinib + Ibrutinib Dubermatinib Ibrutinib 0 1
Durvalumab + Ibrutinib Durvalumab Ibrutinib 0 3
Duvelisib + Ibrutinib Duvelisib Ibrutinib 0 1
Erythromycin + Ibrutinib + Voriconazole Erythromycin Ibrutinib Voriconazole 0 1
Everolimus + Ibrutinib Everolimus Ibrutinib 0 1
Fludarabine + Ibrutinib Fludarabine Ibrutinib 0 1
Fludarabine + Ibrutinib + Pembrolizumab Fludarabine Ibrutinib Pembrolizumab 0 1
Gemcitabine + Ibrutinib + Paclitaxel Gemcitabine Ibrutinib Paclitaxel 0 1
Ibrutinib Ibrutinib 38 56
Ibrutinib + Itacitinib Ibrutinib Itacitinib 0 1
Ibrutinib + Ixazomib Ibrutinib Ixazomib 0 2
Ibrutinib + JCAR017 Ibrutinib JCAR017 0 1
Ibrutinib + JNJ-64052781 Ibrutinib JNJ-64052781 0 1
Ibrutinib + Lenalidomide Ibrutinib Lenalidomide 0 3
Ibrutinib + Lenalidomide + Obinutuzumab + Prednisone + Venetoclax Ibrutinib Lenalidomide Obinutuzumab Prednisone Venetoclax 0 1
Ibrutinib + Lenalidomide + Rituximab Ibrutinib Lenalidomide Rituximab 0 8
Ibrutinib + Loncastuximab tesirine Ibrutinib Loncastuximab tesirine 0 1
Ibrutinib + LY3214996 Ibrutinib LY3214996 0 1
Ibrutinib + Mivavotinib Ibrutinib Mivavotinib 0 1
Ibrutinib + MLN4924 Ibrutinib MLN4924 0 1
Ibrutinib + Monalizumab Ibrutinib Monalizumab 0 1
Ibrutinib + MT-3724 Ibrutinib MT-3724 0 0
Ibrutinib + Nivolumab Ibrutinib Nivolumab 0 8
Ibrutinib + Obinutuzumab Ibrutinib Obinutuzumab 0 8
Ibrutinib + Obinutuzumab + Venetoclax Ibrutinib Obinutuzumab Venetoclax 0 4
Ibrutinib + ONC201 Ibrutinib ONC201 1 0
Ibrutinib + Otlertuzumab Ibrutinib Otlertuzumab 0 1
Ibrutinib + Paclitaxel Ibrutinib Paclitaxel 0 1
Ibrutinib + Pacritinib Ibrutinib Pacritinib 0 1
Ibrutinib + Palbociclib Ibrutinib Palbociclib 1 2
Ibrutinib + Parsaclisib Ibrutinib Parsaclisib 0 1
Ibrutinib + Pembrolizumab Ibrutinib Pembrolizumab 0 5
Ibrutinib + Pembrolizumab + Rituximab Ibrutinib Pembrolizumab Rituximab 0 1
Ibrutinib + Plerixafor Ibrutinib Plerixafor 0 0
Ibrutinib + PQR309 Ibrutinib PQR309 1 0
Ibrutinib + Radiotherapy + SD-101 Ibrutinib Radiotherapy SD-101 0 1
Ibrutinib + Ricolinostat Ibrutinib Ricolinostat 0 1
Ibrutinib + Rituximab Ibrutinib Rituximab 1 4
Ibrutinib + Rituximab + Venetoclax Ibrutinib Rituximab Venetoclax 0 2
Ibrutinib + Ruxolitinib Ibrutinib Ruxolitinib 2 1
Ibrutinib + Sapanisertib Ibrutinib Sapanisertib 0 0
Ibrutinib + SEL24-B489 Ibrutinib SEL24-B489 1 0
Ibrutinib + Selinexor Ibrutinib Selinexor 0 1
Ibrutinib + Silmitasertib Ibrutinib Silmitasertib 1 0
Ibrutinib + SNX-5422 Ibrutinib SNX-5422 0 2
Ibrutinib + Sudemycin D1 Ibrutinib Sudemycin D1 1 0
Ibrutinib + Tafasitamab-cxix Ibrutinib Tafasitamab-cxix 0 1
Ibrutinib + Tazemetostat Ibrutinib Tazemetostat 1 0
Ibrutinib + Temozolomide Ibrutinib Temozolomide 0 1
Ibrutinib + Tisagenlecleucel Ibrutinib Tisagenlecleucel 0 1
Ibrutinib + Trametinib Ibrutinib Trametinib 0 0
Ibrutinib + Trastuzumab Ibrutinib Trastuzumab 0 1
Ibrutinib + Ublituximab Ibrutinib Ublituximab 0 1
Ibrutinib + Ublituximab + Umbralisib Ibrutinib Ublituximab Umbralisib 1 1
Ibrutinib + Ulocuplumab Ibrutinib Ulocuplumab 0 1
Ibrutinib + Umbralisib Ibrutinib Umbralisib 0 2
Ibrutinib + unspecified CTLA4 antibody Ibrutinib unspecified CTLA4 antibody 1 0
Ibrutinib + unspecified PD-L1 antibody Ibrutinib unspecified PD-L1 antibody 1 0
Ibrutinib + VAY736 Ibrutinib VAY736 0 1
Ibrutinib + Venetoclax Ibrutinib Venetoclax 5 13
Ibrutinib + VLX1570 Ibrutinib VLX1570 1 0
Ibrutinib + X4P-001 Ibrutinib X4P-001 0 1
Ibrutinib + YTB323 Ibrutinib YTB323 0 1


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