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Drug Name Pegylated liposomal doxorubicin
Trade Name Doxil
Synonyms ATI-0918|CAELYX|liposomal doxorubicin
Drug Descriptions

Doxil (pegylated liposomal doxorubicin) comprises the anthracyline doxorubicin, which intercalates into DNA and disrupts DNA replication, encapsulated in a liposome, which improves tumor penetration and decreases toxicity (NCI Drug Dictionary), and is FDA approved for ovarian cancer, AIDS-related Kaposi's sarcoma, and multiple myeloma (FDA.gov).

DrugClasses Chemotherapy - Anthracycline 13
CAS Registry Number NA
NCIT ID C1555

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Adavosertib + Pegylated liposomal doxorubicin Adavosertib Pegylated liposomal doxorubicin 0 1
Atezolizumab + Bevacizumab + Pegylated liposomal doxorubicin Atezolizumab Bevacizumab Pegylated liposomal doxorubicin 0 2
Atezolizumab + Carboplatin + Pegylated liposomal doxorubicin Atezolizumab Carboplatin Pegylated liposomal doxorubicin 0 1
Atezolizumab + Pegylated liposomal doxorubicin Atezolizumab Pegylated liposomal doxorubicin 0 1
AVB-S6-500 + Pegylated liposomal doxorubicin AVB-S6-500 Pegylated liposomal doxorubicin 0 1
AZD7648 + Pegylated liposomal doxorubicin AZD7648 Pegylated liposomal doxorubicin 0 1
Bendamustine + Bortezomib + Pegylated liposomal doxorubicin Bendamustine Bortezomib Pegylated liposomal doxorubicin 0 1
Bevacizumab + Carboplatin + Gemcitabine + Paclitaxel + Pegylated liposomal doxorubicin Bevacizumab Carboplatin Gemcitabine Paclitaxel Pegylated liposomal doxorubicin 0 1
Bevacizumab + Pegylated liposomal doxorubicin Bevacizumab Pegylated liposomal doxorubicin 0 5
Bevacizumab + Pegylated liposomal doxorubicin + Temsirolimus Bevacizumab Pegylated liposomal doxorubicin Temsirolimus 3 1
Bortezomib + Pegylated liposomal doxorubicin Bortezomib Pegylated liposomal doxorubicin 0 1
Carboplatin + Everolimus + Pegylated liposomal doxorubicin Carboplatin Everolimus Pegylated liposomal doxorubicin 0 1
Carboplatin + Gemcitabine + Niraparib + Paclitaxel + Pegylated liposomal doxorubicin Carboplatin Gemcitabine Niraparib Paclitaxel Pegylated liposomal doxorubicin 0 0
Carboplatin + Gemcitabine + Paclitaxel + Pegylated liposomal doxorubicin Carboplatin Gemcitabine Paclitaxel Pegylated liposomal doxorubicin 0 1
Carboplatin + Pegylated liposomal doxorubicin Carboplatin Pegylated liposomal doxorubicin 0 3
Carboplatin + Pegylated liposomal doxorubicin + Pembrolizumab Carboplatin Pegylated liposomal doxorubicin Pembrolizumab 0 1
CDX-1140 + CDX-301 + Pegylated liposomal doxorubicin CDX-1140 CDX-301 Pegylated liposomal doxorubicin 0 1
Cytarabine + Dexamethasone + Etoposide + Ibrutinib + Isavuconazole + Pegylated liposomal doxorubicin + Rituximab + Temozolomide Cytarabine Dexamethasone Etoposide Ibrutinib Isavuconazole Pegylated liposomal doxorubicin Rituximab Temozolomide 0 1
Cytarabine + Dexamethasone + Etoposide + Isavuconazole + Pegylated liposomal doxorubicin + Rituximab + Temozolomide Cytarabine Dexamethasone Etoposide Isavuconazole Pegylated liposomal doxorubicin Rituximab Temozolomide 0 1
Dexamethasone + Etoposide + Ibrutinib + Pegylated liposomal doxorubicin + Rituximab + Temozolomide Dexamethasone Etoposide Ibrutinib Pegylated liposomal doxorubicin Rituximab Temozolomide 0 0
Dexamethasone + Etoposide + Ibrutinib + Pegylated liposomal doxorubicin + Temozolomide Dexamethasone Etoposide Ibrutinib Pegylated liposomal doxorubicin Temozolomide 0 1
Dexamethasone + Etoposide + Pegylated liposomal doxorubicin + Rituximab + Temozolomide Dexamethasone Etoposide Pegylated liposomal doxorubicin Rituximab Temozolomide 0 0
Dexamethasone + Pegylated liposomal doxorubicin + Selinexor Dexamethasone Pegylated liposomal doxorubicin Selinexor 0 1
Durvalumab + Pegylated liposomal doxorubicin Durvalumab Pegylated liposomal doxorubicin 0 1
Etrumadenant + IPI-549 + Pegylated liposomal doxorubicin Etrumadenant IPI-549 Pegylated liposomal doxorubicin 0 1
Etrumadenant + Pegylated liposomal doxorubicin Etrumadenant Pegylated liposomal doxorubicin 0 1
Gemcitabine + Paclitaxel + Pegylated liposomal doxorubicin Gemcitabine Paclitaxel Pegylated liposomal doxorubicin 0 1
Gemcitabine + Paclitaxel + Pegylated liposomal doxorubicin + Pembrolizumab Gemcitabine Paclitaxel Pegylated liposomal doxorubicin Pembrolizumab 0 1
Letrozole + Paclitaxel + Pegylated liposomal doxorubicin + Tamoxifen Letrozole Paclitaxel Pegylated liposomal doxorubicin Tamoxifen 0 1
LTX-315 + Pegylated liposomal doxorubicin LTX-315 Pegylated liposomal doxorubicin 0 0
Motolimod + Pegylated liposomal doxorubicin Motolimod Pegylated liposomal doxorubicin 0 0
Paclitaxel + Pegylated liposomal doxorubicin Paclitaxel Pegylated liposomal doxorubicin 0 1
Paclitaxel + Pegylated liposomal doxorubicin + Topotecan Paclitaxel Pegylated liposomal doxorubicin Topotecan 0 3
Pegylated liposomal doxorubicin Pegylated liposomal doxorubicin 0 15
Pegylated liposomal doxorubicin + Pembrolizumab Pegylated liposomal doxorubicin Pembrolizumab 0 2
Pegylated liposomal doxorubicin + Peposertib Pegylated liposomal doxorubicin Peposertib 0 1
Pegylated liposomal doxorubicin + Pomalidomide Pegylated liposomal doxorubicin Pomalidomide 0 1
Pegylated liposomal doxorubicin + RO6839921 Pegylated liposomal doxorubicin RO6839921 1 0
Pegylated liposomal doxorubicin + Romidepsin Pegylated liposomal doxorubicin Romidepsin 0 1
Pegylated liposomal doxorubicin + SL-172154 Pegylated liposomal doxorubicin SL-172154 0 1
Pegylated liposomal doxorubicin + Temsirolimus Pegylated liposomal doxorubicin Temsirolimus 0 0
Pegylated liposomal doxorubicin + Trabectedin Pegylated liposomal doxorubicin Trabectedin 0 1
Pegylated liposomal doxorubicin + Trebananib Pegylated liposomal doxorubicin Trebananib 0 0
Pegylated liposomal doxorubicin + TTI-622 Pegylated liposomal doxorubicin TTI-622 0 1
Pegylated liposomal doxorubicin + Veliparib Pegylated liposomal doxorubicin Veliparib 0 1
Pegylated liposomal doxorubicin + ZN-c3 Pegylated liposomal doxorubicin ZN-c3 0 1


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