Drug Detail

Drug Name Pegylated liposomal-doxorubicin
Trade Name Doxil
Synonyms ATI-0918|CAELYX
Drug Descriptions

Doxil (pegylated liposomal doxorubicin) is doxorubicin encapsulated within a liposome to allow better penetration into tumors, decrease toxicity, and increase the period of effectiveness. Doxorubicin intercalates into DNA, disrupting DNA replication (NCI Drug Dictionary). Doxil (pegylated liposomal doxorubicin) is FDA approved for ovarian cancer, AIDS-related Kaposi's sarcoma and multiple myeloma (FDA.gov).

DrugClasses Chemotherapy - Anthracycline 11

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Therapy Name Drugs Efficacy Evidence Clinical Trials
AB928 + IPI-549 + Pegylated liposomal-doxorubicin AB928 IPI-549 Pegylated liposomal-doxorubicin 0 1
AB928 + Pegylated liposomal-doxorubicin AB928 Pegylated liposomal-doxorubicin 0 1
Atezolizumab + Bevacizumab + Pegylated liposomal-doxorubicin Atezolizumab Bevacizumab Pegylated liposomal-doxorubicin 0 1
Atezolizumab + Pegylated liposomal-doxorubicin Atezolizumab Pegylated liposomal-doxorubicin 0 1
Bendamustine + Bortezomib + Pegylated liposomal-doxorubicin Bendamustine Bortezomib Pegylated liposomal-doxorubicin 0 1
Bevacizumab + Carboplatin + Gemcitabine + Paclitaxel + Pegylated liposomal-doxorubicin Bevacizumab Carboplatin Gemcitabine Paclitaxel Pegylated liposomal-doxorubicin 0 1
Bevacizumab + Pegylated liposomal-doxorubicin Bevacizumab Pegylated liposomal-doxorubicin 0 2
Bevacizumab + Pegylated liposomal-doxorubicin + Temsirolimus Bevacizumab Pegylated liposomal-doxorubicin Temsirolimus 3 1
Bortezomib + Pegylated liposomal-doxorubicin Bortezomib Pegylated liposomal-doxorubicin 0 1
Carboplatin + Everolimus + Pegylated liposomal-doxorubicin Carboplatin Everolimus Pegylated liposomal-doxorubicin 0 1
Carboplatin + Gemcitabine + Paclitaxel + Pegylated liposomal-doxorubicin Carboplatin Gemcitabine Paclitaxel Pegylated liposomal-doxorubicin 0 1
Cytarabine + Dexamethasone + Etoposide + Ibrutinib + Isavuconazole + Pegylated liposomal-doxorubicin + Rituximab + Temozolomide Cytarabine Dexamethasone Etoposide Ibrutinib Isavuconazole Pegylated liposomal-doxorubicin Rituximab Temozolomide 0 1
Cytarabine + Dexamethasone + Etoposide + Isavuconazole + Pegylated liposomal-doxorubicin + Rituximab + Temozolomide Cytarabine Dexamethasone Etoposide Isavuconazole Pegylated liposomal-doxorubicin Rituximab Temozolomide 0 1
Dexamethasone + Etoposide + Ibrutinib + Pegylated liposomal-doxorubicin + Rituximab + Temozolomide Dexamethasone Etoposide Ibrutinib Pegylated liposomal-doxorubicin Rituximab Temozolomide 0 0
Dexamethasone + Etoposide + Ibrutinib + Pegylated liposomal-doxorubicin + Temozolomide Dexamethasone Etoposide Ibrutinib Pegylated liposomal-doxorubicin Temozolomide 0 1
Dexamethasone + Etoposide + Pegylated liposomal-doxorubicin + Rituximab + Temozolomide Dexamethasone Etoposide Pegylated liposomal-doxorubicin Rituximab Temozolomide 0 0
Dexamethasone + Pegylated liposomal-doxorubicin + Selinexor Dexamethasone Pegylated liposomal-doxorubicin Selinexor 1 1
Letrozole + Paclitaxel + Pegylated liposomal-doxorubicin + Tamoxifen Letrozole Paclitaxel Pegylated liposomal-doxorubicin Tamoxifen 0 1
LTX-315 + Pegylated liposomal-doxorubicin LTX-315 Pegylated liposomal-doxorubicin 1 0
Motolimod + Pegylated liposomal-doxorubicin Motolimod Pegylated liposomal-doxorubicin 1 0
Paclitaxel + Pegylated liposomal-doxorubicin Paclitaxel Pegylated liposomal-doxorubicin 0 1
Pegylated liposomal-doxorubicin Pegylated liposomal-doxorubicin 1 6
Pegylated liposomal-doxorubicin + Pembrolizumab Pegylated liposomal-doxorubicin Pembrolizumab 0 1
Pegylated liposomal-doxorubicin + Pomalidomide Pegylated liposomal-doxorubicin Pomalidomide 0 1
Pegylated liposomal-doxorubicin + RO6839921 Pegylated liposomal-doxorubicin RO6839921 1 0
Pegylated liposomal-doxorubicin + Romidepsin Pegylated liposomal-doxorubicin Romidepsin 0 1
Pegylated liposomal-doxorubicin + Temsirolimus Pegylated liposomal-doxorubicin Temsirolimus 1 0
Pegylated liposomal-doxorubicin + Trebananib Pegylated liposomal-doxorubicin Trebananib 1 0
Pegylated liposomal-doxorubicin + Veliparib Pegylated liposomal-doxorubicin Veliparib 0 1


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