Drug Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Pegylated liposomal-doxorubicin
Trade Name Doxil
Synonyms ATI-0918|CAELYX
Drug Descriptions

Doxil (pegylated liposomal doxorubicin) is doxorubicin (intercalates into DNA, disrupting DNA replication) encapsulated, which within a liposome allows better penetration into tumors, decreases toxicity, and increases the period of effectiveness, and is FDA approved for ovarian cancer, AIDS-related Kaposi's sarcoma, and multiple myeloma (FDA.gov).

DrugClasses Chemotherapy - Anthracycline 11

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
AB928 + IPI-549 + Pegylated liposomal-doxorubicin AB928 IPI-549 Pegylated liposomal-doxorubicin 0 1
AB928 + Pegylated liposomal-doxorubicin AB928 Pegylated liposomal-doxorubicin 0 1
Atezolizumab + Bevacizumab + Pegylated liposomal-doxorubicin Atezolizumab Bevacizumab Pegylated liposomal-doxorubicin 0 1
Atezolizumab + Pegylated liposomal-doxorubicin Atezolizumab Pegylated liposomal-doxorubicin 0 1
AVB-S6-500 + Pegylated liposomal-doxorubicin AVB-S6-500 Pegylated liposomal-doxorubicin 0 1
AZD7648 + Pegylated liposomal-doxorubicin AZD7648 Pegylated liposomal-doxorubicin 2 1
Bendamustine + Bortezomib + Pegylated liposomal-doxorubicin Bendamustine Bortezomib Pegylated liposomal-doxorubicin 0 1
Bevacizumab + Carboplatin + Gemcitabine + Paclitaxel + Pegylated liposomal-doxorubicin Bevacizumab Carboplatin Gemcitabine Paclitaxel Pegylated liposomal-doxorubicin 0 1
Bevacizumab + Pegylated liposomal-doxorubicin Bevacizumab Pegylated liposomal-doxorubicin 0 2
Bevacizumab + Pegylated liposomal-doxorubicin + Temsirolimus Bevacizumab Pegylated liposomal-doxorubicin Temsirolimus 3 1
Bortezomib + Pegylated liposomal-doxorubicin Bortezomib Pegylated liposomal-doxorubicin 0 1
Carboplatin + Everolimus + Pegylated liposomal-doxorubicin Carboplatin Everolimus Pegylated liposomal-doxorubicin 0 1
Carboplatin + Gemcitabine + Paclitaxel + Pegylated liposomal-doxorubicin Carboplatin Gemcitabine Paclitaxel Pegylated liposomal-doxorubicin 0 1
Cytarabine + Dexamethasone + Etoposide + Ibrutinib + Isavuconazole + Pegylated liposomal-doxorubicin + Rituximab + Temozolomide Cytarabine Dexamethasone Etoposide Ibrutinib Isavuconazole Pegylated liposomal-doxorubicin Rituximab Temozolomide 0 1
Cytarabine + Dexamethasone + Etoposide + Isavuconazole + Pegylated liposomal-doxorubicin + Rituximab + Temozolomide Cytarabine Dexamethasone Etoposide Isavuconazole Pegylated liposomal-doxorubicin Rituximab Temozolomide 0 1
Dexamethasone + Etoposide + Ibrutinib + Pegylated liposomal-doxorubicin + Rituximab + Temozolomide Dexamethasone Etoposide Ibrutinib Pegylated liposomal-doxorubicin Rituximab Temozolomide 0 0
Dexamethasone + Etoposide + Ibrutinib + Pegylated liposomal-doxorubicin + Temozolomide Dexamethasone Etoposide Ibrutinib Pegylated liposomal-doxorubicin Temozolomide 0 1
Dexamethasone + Etoposide + Pegylated liposomal-doxorubicin + Rituximab + Temozolomide Dexamethasone Etoposide Pegylated liposomal-doxorubicin Rituximab Temozolomide 0 0
Dexamethasone + Pegylated liposomal-doxorubicin + Selinexor Dexamethasone Pegylated liposomal-doxorubicin Selinexor 1 1
Durvalumab + Pegylated liposomal-doxorubicin Durvalumab Pegylated liposomal-doxorubicin 0 1
Letrozole + Paclitaxel + Pegylated liposomal-doxorubicin + Tamoxifen Letrozole Paclitaxel Pegylated liposomal-doxorubicin Tamoxifen 0 1
LTX-315 + Pegylated liposomal-doxorubicin LTX-315 Pegylated liposomal-doxorubicin 1 0
Motolimod + Pegylated liposomal-doxorubicin Motolimod Pegylated liposomal-doxorubicin 3 0
Paclitaxel + Pegylated liposomal-doxorubicin Paclitaxel Pegylated liposomal-doxorubicin 0 1
Pegylated liposomal-doxorubicin Pegylated liposomal-doxorubicin 0 8
Pegylated liposomal-doxorubicin + Pembrolizumab Pegylated liposomal-doxorubicin Pembrolizumab 0 1
Pegylated liposomal-doxorubicin + Pomalidomide Pegylated liposomal-doxorubicin Pomalidomide 0 1
Pegylated liposomal-doxorubicin + RO6839921 Pegylated liposomal-doxorubicin RO6839921 0 0
Pegylated liposomal-doxorubicin + Romidepsin Pegylated liposomal-doxorubicin Romidepsin 0 1
Pegylated liposomal-doxorubicin + Temsirolimus Pegylated liposomal-doxorubicin Temsirolimus 1 0
Pegylated liposomal-doxorubicin + Trebananib Pegylated liposomal-doxorubicin Trebananib 1 0
Pegylated liposomal-doxorubicin + Veliparib Pegylated liposomal-doxorubicin Veliparib 0 1


Additional content available in CKB BOOST