Drug Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name CDX-1140
Trade Name
Synonyms CDX 1140|CDX1140
Drug Descriptions

CDX-1140 is an antibody that binds CD40 and activates signaling, potentially resulting in enhanced anti-tumor immune response (Blood, 128(22), 1848, PMID: 30382327).

DrugClasses CD40 Antibody 14
CAS Registry Number NA
NCIT ID C150558

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
6MHP vaccine + CDX-1140 + NeoAg-mBRAF + Poly ICLC 6MHP vaccine CDX-1140 NeoAg-mBRAF Poly ICLC 0 1
Bevacizumab + CDX-1140 + Pembrolizumab Bevacizumab CDX-1140 Pembrolizumab 0 1
Capecitabine + CDX-1140 + Oxaliplatin + Pembrolizumab CDX-1140 Capecitabine Oxaliplatin Pembrolizumab 0 1
CDX-1140 CDX-1140 0 2
CDX-1140 + CDX-301 CDX-1140 CDX-301 0 3
CDX-1140 + CDX-301 + Pegylated liposomal doxorubicin CDX-1140 CDX-301 Pegylated liposomal doxorubicin 0 1
CDX-1140 + CDX-301 + Poly ICLC CDX-1140 CDX-301 Poly ICLC 0 1
CDX-1140 + iTCR-transduced PBL + Pembrolizumab CDX-1140 Pembrolizumab iTCR-transduced PBL 0 0
CDX-1140 + Pembrolizumab CDX-1140 Pembrolizumab 0 0
CDX-1140 + Pembrolizumab + TSA/TAA-specific TCR engineered T cells CDX-1140 Pembrolizumab TSA/TAA-specific TCR engineered T cells 0 2
CDX-1140 + PGG beta-glucan CDX-1140 PGG beta-glucan 0 1


Additional content available in CKB BOOST