Drug Detail


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Drug Name CDX-1140
Trade Name
Synonyms CDX 1140|CDX1140
Drug Descriptions

CDX-1140 is an antibody that binds CD40 and activates signaling, potentially resulting in enhanced anti-tumor immune response (Blood, 128(22), 1848, PMID: 30382327).

DrugClasses CD40 Antibody 14
CAS Registry Number NA
NCIT ID C150558


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Therapy Name Drugs Efficacy Evidence Clinical Trials
6MHP vaccine + CDX-1140 + NeoAg-mBRAF + Poly ICLC 6MHP vaccine CDX-1140 NeoAg-mBRAF Poly ICLC 0 1
Bevacizumab + CDX-1140 + Pembrolizumab Bevacizumab CDX-1140 Pembrolizumab 0 1
Capecitabine + CDX-1140 + Oxaliplatin + Pembrolizumab CDX-1140 Capecitabine Oxaliplatin Pembrolizumab 0 1
CDX-1140 CDX-1140 0 2
CDX-1140 + CDX-301 CDX-1140 CDX-301 0 3
CDX-1140 + CDX-301 + Pegylated liposomal doxorubicin CDX-1140 CDX-301 Pegylated liposomal doxorubicin 0 1
CDX-1140 + CDX-301 + Poly ICLC CDX-1140 CDX-301 Poly ICLC 0 1
CDX-1140 + iTCR-transduced PBL + Pembrolizumab CDX-1140 Pembrolizumab iTCR-transduced PBL 0 0
CDX-1140 + Pembrolizumab CDX-1140 Pembrolizumab 0 0
CDX-1140 + Pembrolizumab + TSA/TAA-specific TCR engineered T cells CDX-1140 Pembrolizumab TSA/TAA-specific TCR engineered T cells 0 2
CDX-1140 + PGG beta-glucan CDX-1140 PGG beta-glucan 0 1

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